Firooz Alireza; Handjani Farhad; Lajevardi Vahideh; Mansouri Parvin; Nassiri-Kashani Mansour; Norouzi Yasaman
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria. Iranian Society of Dermatology developed ...
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Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria. Iranian Society of Dermatology developed a clinical practice guideline concerning diagnosis and treatment of urticaria that was published in 2015. The current guideline is an update to the previous one and includes findings related to this subject which has been published in the medical literature from 2015 to August 2018.
Lajevardi Vahideh; Ghiasi Maryam; Falahati Ali Asghar; Goodarzi Azadeh
Volume 20, Issue 3 , 2017, , Pages 69-74
Abstract
Background: Vitiligo is an acquired skin discoloration with melanocytic destruction. Vitiligo is associated with other autoimmune disorders; hence, an autoimmune etiology is among the most important theories for this disorder. The nails can be involved in numerous cutaneous or systemic non-cutaneous ...
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Background: Vitiligo is an acquired skin discoloration with melanocytic destruction. Vitiligo is associated with other autoimmune disorders; hence, an autoimmune etiology is among the most important theories for this disorder. The nails can be involved in numerous cutaneous or systemic non-cutaneous disorders. We have taken into consideration previous studies on nail abnormalities in vitiligo and alopecia areata (AA), which are ethologically closely-related, in addition to the few, notwell designed studies on nail changes in vitiligo, and lack of similar studies in Iran. This case-control study was conducted to evaluate the autoimmune etiology of vitiligo with a larger number of participants.Methods: In this case-control study, we assessed the nail characteristics of 303 participants at Razi Hospital, Tehran, Iran from 2013-2014. These changes were also assessed in terms of diseases properties of the case group and included distribution, duration, and presence of other concomitant cutaneous disorders.Results: There was a statistically significant odd’s ratio (OR) for leukonychia in the case and control groups. The relationship between the prevalence of leukonychia and disease duration was meaningful (P0.05). There was no other significant difference between each type of nail abnormality in the case and control groups. We observed no association between these abnormalities and disease duration. None of the nail abnormalities, including leukonychia, had an association with distributionpattern of the disorder.Conclusion: Leukonychia was the most common abnormality in nails of vitiligo patients that had a relation to disease duration.
Abedini Robabeh; Lajevardi Vahideh; Hallaji Zahra; Khodashenas Zohre; Zafar Fatemeh; Nasimi Maryam
Volume 19, Issue 4 , 2016, , Pages 113-118
Abstract
Background: Psoriasis is a chronic skin disorder that can significantly affect a patient’s quality of life (QoL). The goal of this study was to determine the QoL in patients with psoriasis and to investigate the correlation between the QoL, demographic data, and clinical severity of psoriasis.Methods: ...
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Background: Psoriasis is a chronic skin disorder that can significantly affect a patient’s quality of life (QoL). The goal of this study was to determine the QoL in patients with psoriasis and to investigate the correlation between the QoL, demographic data, and clinical severity of psoriasis.Methods: This prospective, cross-sectional study was conducted from April 2014 to January 2015. One hundred patients with plaque type psoriasis from the Phototherapy Clinic of Razi Hospital, Tehran, Iran were selected and asked to complete questionnaires. The Psoriasis Area Severity Index (PASI) to measure the severity of psoriasis, and the Dermatology Life Quality Index (DLQI) was used for the assessment of the quality of life.Results: The total DLQI score of the all participants was between 0 and 29 with a mean score of 10.6 ± 6.4. The DLQI scores ranged from “very large” to “extremely large” in 45% of the patients. The mean score was 9.2 ± 6.6 in the male group and 12.1 ± 5.9 in the female group, which showed a statically significant difference (P=0.02). Other variables associated with an impaired QoL were age (P=0.002) and PASI (P=0.01). The impact on QoL was higher in younger patients, and in patients with higher PASI scores.Conclusion: In conclusion, although psoriasis is a benign disorder, this study confirms our initial hypothesis that psoriasis significantly impairs the QoL, which is more pronounced in younger patients, women, and patients with a more severe disease (higher PASI scores).
Ghandi Narges; Tavassoli Shaghayegh; Ghiasi Maryam; Lajevardi Vahideh; Abedini Robabeh; Tohidinik Hamid-Reza; Daneshpazhooh Maryam
Volume 19, Issue 75 , 2016, , Pages 35-13
Abstract
Background: Prolactin (PRL) appears to play a role in the pathogenesis of autoimmune diseases. Limited evidence showed an association between serum PRL levels and the activity of pemphigus vulgaris (PV). This study intends to determine PRL level changes in pemphigus patients during therapy and its correlation ...
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Background: Prolactin (PRL) appears to play a role in the pathogenesis of autoimmune diseases. Limited evidence showed an association between serum PRL levels and the activity of pemphigus vulgaris (PV). This study intends to determine PRL level changes in pemphigus patients during therapy and its correlation with disease type and severity. Methods: In this cohort study, we measured serum PRL levels by enzyme-linked immunosorbent assay (ELISA) in newly diagnosed PV patients at three time points: before therapy initiation and after two and four months. Concomitantly, we estimated disease severity by the Pemphigus Disease Area Index (PDAI). Results: We examined 42 new cases of PV. Among 32 cases who completed the study, mean serum PRL levels at the three time points were 15.9±14.1 ng/mL (before treatment), 16.7±9.8 ng/ mL (2 months after initiation of treatment), and 15.2±9.2 ng/mL (4 months after initiation of treatment). Mean PDAI values were 19.3±12.8 (before treatment), 3.7±6.2 (2 months after initiation of treatment), and 0.6±1.5 (4 months after initiation of treatment). Although the disease activity decreased significantly (P
Firooz Alireza; Hallaji Zahra; Khatami Alireza; Lajevardi Vahideh; Mansouri Parvin; Pedram Mehryan; Zohreh Mozafari; Mansour Nassiri-Kashani; Reza Robati; Hassan Seirafi
Volume 18, Issue 3 , 2015, , Pages 81-96
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.One of the missions of the Iranian ...
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Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.One of the missions of the Iranian Society of Dermatology is to develop strategies in order to provide the best possible management for patients suffering from dermatological conditions. To accomplish this mission, the Society assigned a committee to search and critically appraise the recent research evidence and available guidelines to develop a clinical practice guideline concerning diagnosis and treatment of urticaria.
Lajevardi Vahideh; Nazemi Mohammad Javad; Khodashenas Zohreh; Ebadi Mohammad-Sadegh
Volume 17, Issue 2 , 2014, , Pages 59-62
Abstract
Background: Generalized vitiligo is characterized by autoimmunedestruction of melanocytes, which results in patches of thedepigmented skin and the overlying hair. Vitamin D is an essentialhormone synthesized in the skin and is responsible for skinpigmentation. Low vitamin D levels have been noted in ...
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Background: Generalized vitiligo is characterized by autoimmunedestruction of melanocytes, which results in patches of thedepigmented skin and the overlying hair. Vitamin D is an essentialhormone synthesized in the skin and is responsible for skinpigmentation. Low vitamin D levels have been noted in patientswith a variety of autoimmune diseases. A recent study showedthat low vitamin D levels may be associated with vitiligo. Theaim of this study was to compare 25-hydroxyvitamin D (25[OH]D) levels in Iranian patients with vitiligo with normal controls.Method: In this case-control study, we studied 30 newly diagnosedpatients with vitiligo and 30 healthy controls through a casecontrol design. Two groups were matched for gender, age, andthe season in which the serum levels of 25-hydroxy vitamin Dwere measured. The serum levels were categorized as sufficient,insufficient and deficient.Result: The mean serum level of vitamin D was 10.24±1.27 ng/mL in patients compared to 18.31±7.39 ng/mL in the controlgroup. Male patients had lower levels of vitamin D compared tocontrols (7.25 ng/mL vs. 13.31ng/mL, P=0.03), while no significantdifference was observed between females and controls (14.12 ng/mL vs. 16.25 ng/mL, P=0.51).Conclusion: The present study demonstrated that there may be anassociation between low levels of Vitamin D3 and vitiligo in men.
Mortazavi Hossein; Aghazadeh Nessa; Ghiasi Maryam; Lajevardi Vahideh
Volume 16, Issue 4 , 2013, , Pages 144-158
Abstract
Retinoids are synthetic and natural analogues of vitamin A that have various effects on cellular differentiation, cellular proliferation, immune system, and embryonic development. The present study reviews the history of systemic retinoids in medicine, the structure of syn
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Retinoids are synthetic and natural analogues of vitamin A that have various effects on cellular differentiation, cellular proliferation, immune system, and embryonic development. The present study reviews the history of systemic retinoids in medicine, the structure of syn
Balighi Kamran; Jamshidi Samaneh; Daneshpajooh Maryam; Lajevardi Vahideh; Aalami Harandi Sima; Ghassemi Hamed
Volume 14, Issue 3 , 2011, , Pages 95-99
Abstract
Background: Treatment of acne scars is a therapeutic challenge that may require multiple modalities. Subcision is a procedure that has been reported to be beneficial in the treatment of acne scars. Although subcision is a valuable method, its efficacy is mild to moderate due to the high recurrence rate. ...
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Background: Treatment of acne scars is a therapeutic challenge that may require multiple modalities. Subcision is a procedure that has been reported to be beneficial in the treatment of acne scars. Although subcision is a valuable method, its efficacy is mild to moderate due to the high recurrence rate. This study aimed to evaluate the novel complementary treatment of repeated suction sessions plus subcision at the recurrence period of subcised scars. Methods: The standard technique of subcision was applied to treat scars in 12 patients; then, one side of the face underwent repeated suctioning for 2 weeks. All patients completed treatment and the follow-up period. The patients’ and investigators’ assessments of improvement were both recorded. Results: According to patients and investigators, subcision plus suction showed 81% and 65% improvement after 3 month, respectively. Subcision alone, after 3 month, was associated with 62% and 33.3% improvement according to patients and investigators, respectively. The rate of response showed a significant difference with the use of repeated suctioning. The side-effects of local edema and bruising were all transient. Conclusion: Subcision plus frequent suctioning at the recurrence period of subcision appears to be a safe technique that increases the efficacy of subcision without considerable complications.
Akhiani Maryam; Fateh Soheil; Ghanadan Alireza; Lajevardi Vahideh
Volume 12, Issue 3 , 2009, , Pages 99-102
Abstract
Blue rubber bleb nevus syndrome is a sporadic disease with widely distributed dark blue papules and nodules and soft skin-colored compressible protuberances (rubber blebs) as well as large vascular malformations. Gasterointestinal lesions are documented by upper endoscopy and colonoscopy; hemorrhages ...
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Blue rubber bleb nevus syndrome is a sporadic disease with widely distributed dark blue papules and nodules and soft skin-colored compressible protuberances (rubber blebs) as well as large vascular malformations. Gasterointestinal lesions are documented by upper endoscopy and colonoscopy; hemorrhages from these lesions create irondeficinecy anemia. Other sites of visceral involvement are less common. We report a 20-year-old male with multiple blue venous nodules on the face, neck, trunk and limbs with occasional bleeding. In addition, he had similar lesions in buccal mucosa and genitalia. Endoscopic examination revealed blue nodular lesions in gastrointestinal tract. Lab tests showed iron deficiency anemia.
Balighi Kamran; Lajevardi Vahideh; Ghiasi Maryam; Farahani Farzaneh; Nikoo Azita
Volume 11, Issue 1 , 2008, , Pages 34-37
Abstract
We report phakomatosis pigmentovascularis (PPV) detected in a 40- year-old male characterized by the presence of a port-wine stain in the background of aberrant Mongolian spots covering the back, nevus of Ota, ocular melanosis, epidermal nevus and a scaly patch with the diagnosis of discoid lupus erytematosus. ...
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We report phakomatosis pigmentovascularis (PPV) detected in a 40- year-old male characterized by the presence of a port-wine stain in the background of aberrant Mongolian spots covering the back, nevus of Ota, ocular melanosis, epidermal nevus and a scaly patch with the diagnosis of discoid lupus erytematosus. These associations have not been reported yet.
Balighi Kamran; Lajevardi Vahideh; Moeineddin Fatemeh; Naraghi Zahra; Irvani Masoud
Volume 11, Issue 1 , 2008, , Pages 38-41
Abstract
A 15-year-old boy presented with several months history of bilateral axillary lymph adenopathies which were ulcerated subsequently. He had received anti-tuberculosis therapy for more than six months based on suspicious diagnosis of scrofuloderma. Histopathologic examination confirmed the diagnosis of ...
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A 15-year-old boy presented with several months history of bilateral axillary lymph adenopathies which were ulcerated subsequently. He had received anti-tuberculosis therapy for more than six months based on suspicious diagnosis of scrofuloderma. Histopathologic examination confirmed the diagnosis of specific lesions of Hodgkin’s disease. These lesions were probably metastatic due to retrograde lymphatic spread from his axillary lymph nodes, as this way is the most common mode of Hodgkin’s disease spreading to the skin. The patient received chemotherapy regimen for Hodgkin’s disease and ulcers resolved remarkably.
Balighi Kamran; Lajevardi Vahideh; Moeineddin Fatemeh; Ghiassi Maryam; Arami Shabnam; Nikoo Azita; Mahdavi-nia Mostafa
Volume 10, Issue 4 , 2007, , Pages 338-344
Abstract
Atrichia with papular lesions (APL) is a rare, autosomal recessive syndrome with total alopecia in which mutations in the hairless gene have been shown to underlie the phenotype. We report here three cases, two 16 and 18 years old cousins and a 15 year-old-girl with a history of shedding of scalp, eyebrow ...
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Atrichia with papular lesions (APL) is a rare, autosomal recessive syndrome with total alopecia in which mutations in the hairless gene have been shown to underlie the phenotype. We report here three cases, two 16 and 18 years old cousins and a 15 year-old-girl with a history of shedding of scalp, eyebrow and eye lashes in infancy. Later in life they developed numerous erythematous papules on their limbs predominantly on the knees and elbows. According to their history, clinical presentation and pathologic findings, diagnosis of atrichia with papular lesions (APL) with some different features was postulated. Comparing to the known cases of APL with scalp, facial and truncal lesions, the cases presented here do not show such lesions in these sites.