Ghalamkarpour Fariba; Niknafs Faranak; Younespour Shima
Volume 19, Issue 75 , 2016, , Pages 169-173
Abstract
Background: Erythroderma is an inflammatory disorder. It has various differential diagnoses, among which one of the most important is mycosis fungoides. Erythroderma itself can be a challenging disorder. Diagnosis of a mycosis fungoides patient presenting with erythroderma specially requires a careful ...
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Background: Erythroderma is an inflammatory disorder. It has various differential diagnoses, among which one of the most important is mycosis fungoides. Erythroderma itself can be a challenging disorder. Diagnosis of a mycosis fungoides patient presenting with erythroderma specially requires a careful assessment of the peripheral blood. Studies such as CD markers can lead to a more accurate diagnosis of mycosis fungoides.Methods: In this study, we evaluated ten erythrodermic patients in order to identify the source of their erythema. The underlying causes were both benign such as eczema, psoriasis, pityriasis rubra pilaris, acute generalized exanthematous pustulosis and malignant like hypereosinophilic syndrome and mycosis fungoided. Results: The CD4/CD8 ratio was greater than 10 in 2 out of 10 erythrodermic patients. These patients had decreased levels of CD7 and CD26 expression. While one of the two patients fulfilled the criteria of hypereosinophilic syndrome, the other one did not have a documented clincopathologic diagnosis and had a pathology report of lichenoid tissue reaction with eosinophilia in favor of drug reaction. Both patients had decreased levels of CD7 and CD26 expression.Conclusion: Since pathology is usually non-specific and cannot differentiate between the causes of erythroderma in erythrodermic patient with CTCL, peripheral blood findings including flow cytometry and the analysis of CD4/CD8, CD7, CD26 and CD27 expression are useful techniques which can be used for a prompt diagnosis.
Ebadi Atyeh; Moravvej Hamideh; Hejazi Somayeh; Younespour Shima; Ghalamkarpour Fariba
Volume 16, Issue 3 , 2013, , Pages 89-93
Abstract
Background: Despite great advances in therapeutic regimens,complete repigmentation in vitiligo is still out of reach. The aimof this assay was to study the efficacy and tolerability of repeatedneedling combined with narrowband ultraviolet B (NBUVB)therapy in the treatment of generalized, stable, refractory ...
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Background: Despite great advances in therapeutic regimens,complete repigmentation in vitiligo is still out of reach. The aimof this assay was to study the efficacy and tolerability of repeatedneedling combined with narrowband ultraviolet B (NBUVB)therapy in the treatment of generalized, stable, refractory vitiligo.Method: Twenty-six patients with stable generalized intractablevitiligo were recruited in before/after clinical trial. The patientsreceived needling for selected patches weekly for 12 weeks. Allthe patients received NBUVB phototherapy three times a week.Repigmentation improvement was assessed by two blindedinvestigators at weeks 4, 8 and 12. Tolerability was assessed bya 5-point scale.Result: Twenty-two patients (16 women and 6 men) with a mean(SD) age of 34.41 (12.75) years completed the 12-week therapyperiod. In comparison with the baseline, improvement in themean percentage of repigmentation was 7.10±10.15, 12.95±20.29,and 15.57±17.38 at week 4, 8 and 12 of therapy, respectively.A significant improvement was observed in repigmentationpercentages in the three time points (p
Ghalamkarpour Fariba; Saeedi Marjan; Hedayati Mehdi; Maarefat Afsaneh
Volume 13, Issue 1 , 2010, , Pages 9-11
Abstract
Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study ...
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Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study was to describe selected immunological changes, concerning adhesion molecules status (sEselectin, sP-selectin), in psoriasis and also their correlation with disease activity. Method: Serum levels of soluble E-selectin and soluble P-selectin were measured by enzyme-linked immunosorbent assay in 58 patients with psoriasis and 24 healthy control subjects. The relationships between these adhesion molecules and the Psoriasis Areaand Severity Index score were investigated. Result: There was a significant correlation between the serum soluble E-selectin levels and Psoriasis Area and Severity Index score. Conclusion: Soluble E-selectin serum levels correlate with the extent of psoriatic lesions and could be used as marker of the disease activity in psoriatic patients but this finding needs further modification.