Barzegari Massoume; Valikhani Mahin; Esmaili Nafiseh; Naraghi Zahra; Nikoo Azita; Kamyab Kambiz; Ghanadan Ali; Tamizifar Banafshe
Volume 11, Issue 2 , 2008, , Pages 64-66
Abstract
Background: Pemphigus vulgaris (PV) is an autoimmune blistering disease, caused by autoantibodies against desmoglein (Dsg) 3 and / or Dsg1 which induce the loss of adhesion between keratinocytes. Nikolsky's sign is the ability to induce peripheral extension of a blister as a consequence of applying lateral ...
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Background: Pemphigus vulgaris (PV) is an autoimmune blistering disease, caused by autoantibodies against desmoglein (Dsg) 3 and / or Dsg1 which induce the loss of adhesion between keratinocytes. Nikolsky's sign is the ability to induce peripheral extension of a blister as a consequence of applying lateral pressure to the border of an intact blister. If the weakening of the intercellular adhesion is present but not marked, then the damage may be demonstrated only microscopically (microscopic Nikolsky’s sign and can increase the sensitivity of the histopathological studies. Methods: We studied 40 patients and divided them randomly into two groups (A, B). Group A were subjected to the tangential pressure over the perilesional skin before a biopsy specimen was taken from that site; group B patients were subjected to a biopsy without the tangential pressure technique. Results: Histopathological changes of pemphigus vulgaris were present in 30% of the patients in group A and 5% of the patients in group B. They were not statistically different. The presence of microscopic Nikolsky’s sign was significantly higher in patients with generalized disease. Conclusion: Microscopic Nikolsky sign can increase the sensitivity of histologic diagnosis of PV.
Balighi Kamran; Lajevardi Vahideh; Moeineddin Fatemeh; Naraghi Zahra; Irvani Masoud
Volume 11, Issue 1 , 2008, , Pages 38-41
Abstract
A 15-year-old boy presented with several months history of bilateral axillary lymph adenopathies which were ulcerated subsequently. He had received anti-tuberculosis therapy for more than six months based on suspicious diagnosis of scrofuloderma. Histopathologic examination confirmed the diagnosis of ...
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A 15-year-old boy presented with several months history of bilateral axillary lymph adenopathies which were ulcerated subsequently. He had received anti-tuberculosis therapy for more than six months based on suspicious diagnosis of scrofuloderma. Histopathologic examination confirmed the diagnosis of specific lesions of Hodgkin’s disease. These lesions were probably metastatic due to retrograde lymphatic spread from his axillary lymph nodes, as this way is the most common mode of Hodgkin’s disease spreading to the skin. The patient received chemotherapy regimen for Hodgkin’s disease and ulcers resolved remarkably.