Mohammad Shahidi-Dadras; Parviz Toossi; Reza Jafari Fesharaki; Azin Ayatollahi; Mehdi Qeisari; Shima Younespour
Volume 16, Issue 1 , 2013, , Pages 9-12
Abstract
Background: To our knowledge, there is a hypothesis regardingthe association of vitiligo with other autoimmune disorders.Organ-specific autoantibodies are found more frequently in theserum of vitiligo patients. Recent studies have demonstratedthe role of alterations in serum transforming growth factor-beta(TGF-beta) ...
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Background: To our knowledge, there is a hypothesis regardingthe association of vitiligo with other autoimmune disorders.Organ-specific autoantibodies are found more frequently in theserum of vitiligo patients. Recent studies have demonstratedthe role of alterations in serum transforming growth factor-beta(TGF-beta) released from regulatory T cells in the pathogenesisof depigmentation observed in vitiligo. It has been shown that incomparison with patients without autoimmune diseases, serumTGF-beta levels increase in patients whose vitiligo is associatedwith autoimmune diseases. We hypothesized a relationshipbetween serum TGF-beta levels and organ-specific autoantibodiesthat could predict other autoimmune diseases in vitiligo patients.Method: Forty-five patients with a mean age of 35.96±13.34years who had stable vitiligo since 1 year ago and involvementof up to 30% body surface area were enrolled. Organ-specificautoantibodies (ANA, anti mitochondrial Ab, anti TPO (antithyroid microsomal Ab), anti parietal cell Ab, anti thyroglobulinAb) and serum TGF-beta level were evaluated.Result: Twenty-three patients (51.11%) had at least one positiveorgan-specific autoantibody. Anti TPO in 16 patients, antithyroglobulin Ab in 9 patients, anti parietal cell Ab and ANAeach in 5 patients, and anti mitochondrial Ab in 4 patients werepositive. Mean serum TGF-beta level was 105.82±30.33; there wasno significant difference in serum TGF-b level between patientswith and without positive organ-specific autoantibody (P=0.26).Conclusion: Although another study showed the relationshipbetween serum TGF-beta levels and autoimmune disordersin vitiligo patients, we did not find a significant difference inserum TGF-beta levels in these patients regarding the positivityof organ-specific antibodies. It may be due to the fact that ourpatients had autoantibodies without clinical autoimmune diseaseexcept vitiligo.
Zahra Asadi Kani; Farhad Malekzad; Mehdi Qeisari; Nastaran Namazi
Volume 13, Issue 4 , 2010, , Pages 135-138
Abstract
The association between actinic granuloma and giant cell arteritis (temporal arteritis) has been claimed by some authors. There is a hypothesis that actinic radiation has the principal role in the etiology of both diseases in a similar way. Here, we report a case of actinic granuloma that had characteristic ...
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The association between actinic granuloma and giant cell arteritis (temporal arteritis) has been claimed by some authors. There is a hypothesis that actinic radiation has the principal role in the etiology of both diseases in a similar way. Here, we report a case of actinic granuloma that had characteristic pathologic features of giant cell arteritis in histopathologic examination without clinical evidence of giant cell arteritis.
Reza Mahmoud Robati; Zahra Asadi Kani; Mehdi Qeisari
Volume 12, Issue 3 , 2009, , Pages 103-104
Abstract
A 21-year-old man was referred to dermatology clinic for skin biopsy. He presented to neurology center with behavioral changes with cognition and memory disorders. He had two episodes of genealized tonic clonic seizure and series of myoclonc jerks in his limbs and face especially after awakening since ...
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A 21-year-old man was referred to dermatology clinic for skin biopsy. He presented to neurology center with behavioral changes with cognition and memory disorders. He had two episodes of genealized tonic clonic seizure and series of myoclonc jerks in his limbs and face especially after awakening since several months ago. In neurological examination, he had mini mental score as 13; with some degree of bradykinesia, limb rigidity and dysartheria. He had leaved school because of inability to learning. His sister had died 5 months ago from the same disease. We performed biopsy from his right axillary skin. Histopathological examination revealed multiple intracytoplasmic homogenous pale basophilic globi in apocrine glands acini which were showing PAS positive reactivity in special staining. Reminder of epidermis and mid reticular dermis was unremarkable.