Dastgheib Ladan; Saki Nasrin; Heiran Alireza; Kardeh Bahareh; Saki Mohammad Reza
Volume 20, Issue 3 , 2017, , Pages 79-83
Abstract
Background: Psoriasis is a chronic autoimmune skin disorder with relapsing erythematous scaling plaques and joint or nail involvement. A greater occurrence of other autoimmune diseases has been reported in these patients. Additionally, their family members are more likely to be diagnosed with psoriasis. ...
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Background: Psoriasis is a chronic autoimmune skin disorder with relapsing erythematous scaling plaques and joint or nail involvement. A greater occurrence of other autoimmune diseases has been reported in these patients. Additionally, their family members are more likely to be diagnosed with psoriasis. The aimof this study is to assess the prevalence of certain autoimmune diseases in first degree relatives of patients with psoriasis compared with a control group. Methods: In this cross-sectional study we used a questionnaire to compare the frequency of type 1 diabetes, autoimmune thyroid disease, vitiligo, lupus erythematosus, multiple sclerosis, ulcerative colitis, Crohn’s disease, and rheumatoid arthritis in first degree relatives of 109 pathologically confirmed psoriasiscases with the first degree relatives of 109 age-sex matched controls. R programming language (version 3.3.1 for Windows) and the rattle graphical user interface (GUI) package were applied for statistical analysis. A P-value?0.05 was considered to be statistically significant. Results: We compared 955 first degree relatives of psoriatic patients with 934 family members of the controls. There was significantly greater total autoimmune diseases [odds ratio (OR): 2.74, 95% confidence interval (CI): 1.95-3.87, P<0.001), particularly psoriasis (OR: 38.66, 95% CI: 5.3-282.19, P<.0001), in first degree relatives of psoriatic patients compared to family members of the control group. Regardless of gender, autoimmune thyroid disease was more prevalent among first degree relatives of psoriatic patients (OR: 2.81, 95% CI: 1.36-5.83, P=.0066). No statistically significant difference was found regarding type 1 diabetes, rheumatoid arthritis, multiple sclerosis, vitiligo, Crohn’s disease, and ulcerative colitis. Conclusion: First degree relatives of patients with psoriasis had significantly higher autoimmune diseases. This finding was particularly noticed for psoriasis and autoimmune thyroid disease.
Emad Maryam; Moezzi Jafar; Dastgheib Ladan
Volume 16, Issue 1 , 2013, , Pages 13-5
Abstract
Background: Melasma is an acquired therapeutically problematicdisease characterized by symmetrical facial hypermelanosis. Theaim of this study was to evaluate the efficacy of azelaic acid20% cream in the treatment of melasma in Iranian patients andcompare it with hydroquinone 4% cream which has been ...
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Background: Melasma is an acquired therapeutically problematicdisease characterized by symmetrical facial hypermelanosis. Theaim of this study was to evaluate the efficacy of azelaic acid20% cream in the treatment of melasma in Iranian patients andcompare it with hydroquinone 4% cream which has been thestandard treatment.Method: The study was an open clinical trial with a split-facedesign. All patients applied hydroquinone 4% cream on theright side and azelaic acid 20% cream on the left side for 20weeks. Modified melasma area and severity index (mMASI) wasdetermined for each patient at the beginning and at the end ofstudy and compared statistically.Result: Thirty-three patients were included in the study. Althoughboth medications were effective in reducing mMASI, there wasno statistical difference between the two (P value=0.6). Overall,69.7% of the patients on the hydroquinone 4% side and 63.6%on the azelaic acid 20% side showed good to excellent response.The subjective patient assessment of improvement was 75.7% forhydroquinone 4% and 66.6% for azelaic acid 20%.Conclusion: Both topical hydroquinone 4% and topical azelaicacid 20% had almost similar effects. Considering the relativelyless known side effects of azelaic acid compared to hydroquinone,it can be an appropriate substitute in the treatment of melasma.