MJ Nazemi; S Sotoodeh; H Moslehi
Volume 6, Issue 2 , 2003, , Pages 5-13
Abstract
Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The ...
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Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The clinical, Paraclinical and pathological findings in 50 biopsy proven patients with DLE referred to Razi Hospital in Tehran in 1377 were recorded in special questionnaires. Data were analyzed by SPSS software, T-Student and chi-square tests were used. Results: The number of female patients was twice of males, majority in the age range of 20 to 50 years, Most of the patients had no complaints except for skin eruptions. Paraclinical abnormalities were rare. The paraclinical changes were various, but hydropic degeneration of basal layer was found in all cases. Conclusion: Complementary studies are suggested to evaluate similarities and differences in Iranian and non-Iranian patients with DLE.
Z Safaei Naraghi; Z Hallaji; M Danesh Pajooh; H Moslehi; K Jazayeri
Volume 4, Issue 1 , 2000, , Pages 12-18
Abstract
Background: Bullous pemphigoid (BP) is the prototype of subepidermal autoimmune bullous dermatoses (SABDs). Direct immunofluorescence on salt split skin substrate (DIF-SS) is one of the methods used to differentiate this group of dermatoses. Objective: We conducted this study in order to delineate the ...
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Background: Bullous pemphigoid (BP) is the prototype of subepidermal autoimmune bullous dermatoses (SABDs). Direct immunofluorescence on salt split skin substrate (DIF-SS) is one of the methods used to differentiate this group of dermatoses. Objective: We conducted this study in order to delineate the results of DIF-SS in SABD patients. Patients and Methods: Seventeen patients with a BP-like clinical picture referred to Razi Hospital in 1378, who had linear immunodeposits along basement membrane zone in direct immunofluorescence, were studied. Considering only histopathologic and clinical data, a final diagnosis was established for each patient. DIF-SS was performed on perilesional skin sample of patients. DIF-SS and histopathology results and the final diagnosis were recorded and compared for each patient. Results: In DIF-SS, eleven patients (65%) had combined (Epidermal and dermal), two patients (12%) had epidermal and four patients (23%) had dermal pattern. The final diagnoses were BP in ten patients and epidermolysis bullosa acquisita (EBA) in two others. We were unable to differentiate BP from EBA in two patients. In ten patients who were diagnosed finally as BP, nine patients (90%) had combined pattern and only one case (10%) showed epidermal staining in DIF-SS. Conclusion: Surprisingly, in contrast to the results of the previous studies on pemphigoid patients using either IIF-SS or DIF-SS in which the epidermal pattern had been reported to be much more common than the combined pattern, the combined pattern was nine times more frequent than the epidermal pattern in this study. Perhaps, the difference in target antigens in our patients may be the underlying reason for the difference in our results.
