F Jafari; Sh Moradi; MA Nilforoush Zadeh; R Derakhshan; N Ansari
Volume 9, Issue 3 , 2006, , Pages 211-216
Abstract
Background and aim: Cutaneous leishmaniasis is an endemic disease in Iran. Although there are many different treatments for this disease, there is not any effective treatment yet. Since there has been a number of different reports on the effectiveness of Cassia fistula plant in the treatment of leishmaniasis, ...
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Background and aim: Cutaneous leishmaniasis is an endemic disease in Iran. Although there are many different treatments for this disease, there is not any effective treatment yet. Since there has been a number of different reports on the effectiveness of Cassia fistula plant in the treatment of leishmaniasis, the efficacy of concentrated boiled extract and hydro alcoholic extract of Cassia fistula on the leishmaniasis disease was compared with intralesional injection of Glucantime in this study.Materials and Methods: In this randomized clinical trial a total of 165 patients, 6 to 60 years old, who had a positive leishmania smear refered to the Isfahan Skin and Leishmaniasis Research Center were divided into three groups using list of random numbers and were treated with: concentrated boiled extract of Cassia fistula, hydroalcholic extract of Cassia fistula, or intralesional injection of Glucantime. The patients were treated for 4 weeks and followed for three months after the study started. The efficacy of treatment was reported as complete cure, partial improvement and no improvement on the basis of clinical and parasitological evidence.Results: In the present study 63/6% of patients treated with the concentrated boiled extract, 52/7% of the hydroalcoholic extract and 45/5% of the Glucantime group were men. 22 patients (40%) of the concentrated boiled extract of Cassia fistula, 20 pateints (36/4%) of the hydroalcoholic extract of Cassia fistula group and 36 patients (65/5%) of the Glucantime group showed complete cure. The efficacy in the third group was much more than the first (P<0.02) and second groups (P<0.005), but there was not any difference between concentrated boiled extract and hydroalcoholic extract of Cassia fistula.Conclusion: The results of this study showed that this plant might be used topically along with Glucantime for decreasing the time and dose of treatment with Glucantime.
MA Nilforoush Zadeh; F Jafari; N Ansari; Z Nilforoushan; AR Firooz
Volume 8, Issue 5 , 2005, , Pages 340-346
G Sadeghian; MA Nilforoosh Zadeh; N Ansari
Volume 7, Issue 2 , 2004, , Pages 112-115
Abstract
Cutaneous leishmaniasis is a parasitic hyperendemic disease in Isfahan. Its lesions can be solitary or multiple depending on the number of insect bites and is usually seen exposed areas. The possibility of insect bite on palpebral area is rare due to the protection by eyelashes and palpebral motion. ...
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Cutaneous leishmaniasis is a parasitic hyperendemic disease in Isfahan. Its lesions can be solitary or multiple depending on the number of insect bites and is usually seen exposed areas. The possibility of insect bite on palpebral area is rare due to the protection by eyelashes and palpebral motion. In this area, lesions are usually presented as chalazion, dacryocystitis and rarely ulcerative and cancerous forms. As there is a chance of dissemination of the parasite to conjunctiva, cornea and sclera from the adjacent skin, and it is also possible that scarring of cutaneous leishmaniasis may cause some ophthalmologic side effects, this kind of leishmaniasis can potentially be very serious for eyes. In this report, a 13 year old boy with upper and lower palpebral cutaneous leishmaniasis who consequently developed conjunctivitis and trichiasis is presented. This patient responded to treatment with systemic glucantime, but ultimately developed conjunctival and palpebral scar, exposure keratitis and loss of eyelashes.
