Fariba Ghalamkarpour; Faranak Niknafs; Shima Younespour
Volume 18, Issue 4 , 2015, , Pages 169-173
Abstract
Background: Erythroderma is an inflammatory disorder. It has various differential diagnoses, among which one of the most important is mycosis fungoides. Erythroderma itself can be a challenging disorder. Diagnosis of a mycosis fungoides patient presenting with erythroderma specially requires a careful ...
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Background: Erythroderma is an inflammatory disorder. It has various differential diagnoses, among which one of the most important is mycosis fungoides. Erythroderma itself can be a challenging disorder. Diagnosis of a mycosis fungoides patient presenting with erythroderma specially requires a careful assessment of the peripheral blood. Studies such as CD markers can lead to a more accurate diagnosis of mycosis fungoides.Methods: In this study, we evaluated ten erythrodermic patients in order to identify the source of their erythema. The underlying causes were both benign such as eczema, psoriasis, pityriasis rubra pilaris, acute generalized exanthematous pustulosis and malignant like hypereosinophilic syndrome and mycosis fungoided.Results: The CD4/CD8 ratio was greater than 10 in 2 out of 10 erythrodermic patients. These patients had decreased levels of CD7 and CD26 expression. While one of the two patients fulfilled the criteria of hypereosinophilic syndrome, the other one did not have a documented clincopathologic diagnosis and had a pathology report of lichenoid tissue reaction with eosinophilia in favor of drug reaction. Both patients had decreased levels of CD7 and CD26 expression.Conclusion: Since pathology is usually non-specific and cannot differentiate between the causes of erythroderma in erythrodermic patient with CTCL, peripheral blood findings including flow cytometry and the analysis of CD4/CD8, CD7, CD26 and CD27 expression are useful techniques which can be used for a prompt diagnosis.
Mohammad Shahidi-Dadras; Parviz Toossi; Reza Jafari Fesharaki; Azin Ayatollahi; Mehdi Qeisari; Shima Younespour
Volume 16, Issue 1 , 2013, , Pages 9-12
Abstract
Background: To our knowledge, there is a hypothesis regardingthe association of vitiligo with other autoimmune disorders.Organ-specific autoantibodies are found more frequently in theserum of vitiligo patients. Recent studies have demonstratedthe role of alterations in serum transforming growth factor-beta(TGF-beta) ...
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Background: To our knowledge, there is a hypothesis regardingthe association of vitiligo with other autoimmune disorders.Organ-specific autoantibodies are found more frequently in theserum of vitiligo patients. Recent studies have demonstratedthe role of alterations in serum transforming growth factor-beta(TGF-beta) released from regulatory T cells in the pathogenesisof depigmentation observed in vitiligo. It has been shown that incomparison with patients without autoimmune diseases, serumTGF-beta levels increase in patients whose vitiligo is associatedwith autoimmune diseases. We hypothesized a relationshipbetween serum TGF-beta levels and organ-specific autoantibodiesthat could predict other autoimmune diseases in vitiligo patients.Method: Forty-five patients with a mean age of 35.96±13.34years who had stable vitiligo since 1 year ago and involvementof up to 30% body surface area were enrolled. Organ-specificautoantibodies (ANA, anti mitochondrial Ab, anti TPO (antithyroid microsomal Ab), anti parietal cell Ab, anti thyroglobulinAb) and serum TGF-beta level were evaluated.Result: Twenty-three patients (51.11%) had at least one positiveorgan-specific autoantibody. Anti TPO in 16 patients, antithyroglobulin Ab in 9 patients, anti parietal cell Ab and ANAeach in 5 patients, and anti mitochondrial Ab in 4 patients werepositive. Mean serum TGF-beta level was 105.82±30.33; there wasno significant difference in serum TGF-b level between patientswith and without positive organ-specific autoantibody (P=0.26).Conclusion: Although another study showed the relationshipbetween serum TGF-beta levels and autoimmune disordersin vitiligo patients, we did not find a significant difference inserum TGF-beta levels in these patients regarding the positivityof organ-specific antibodies. It may be due to the fact that ourpatients had autoantibodies without clinical autoimmune diseaseexcept vitiligo.
Farhad Malekzad; Reza Robati; Hamidreza Abaei; Somayeh Hejazi; Azin Ayatollahi; Shima Younespour
Volume 14, Issue 4 , 2011, , Pages 136-139
Abstract
Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance.Methods: This single-centre, ...
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Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance.Methods: This single-centre, case- control study was performed between 2008 and 2010 to evaluate the metabolic state of thirty chronic plaque type psoriatic patients in comparison with the control group. The criteria of insulin resistance (Body Mass Index (BMI), Systolic Blood Pressure, Fasting Plasma Glucose, Oral Glucose Tolerance Test (OGTT), Serum Insulin and Lipid Profile) were assessed for each participant.Results: Thirty psoriatic patients with a mean disease duration of 3.94 + 2.96 years and 30 healthy controls were recruited for the study. Only one patient in each group filled the criteria of insulin resistance, and there was no significant difference between the two groups. The mean Fasting Plasma Glucose (FPG), Triglyceride (TG) and Systolic Blood Pressure (SBP) levels were significantly higher in psoriasis patients as compared to the controls (p=0.044, p=0.014 and p=0.001, respectively). In contrast, no statistically significant differences were observed in mean BMI, OGTT, insulin and HDL levels between the two groups.Conclusion: Despite the absence of any significant association between insulin resistance and psoriasis, it could be concluded that psoriasis may be an independent risk factor for diseases such as Ischemic Heart Disease (IHD) and Diabetes Mellitus (DM), hypertension and obesity.
Nasrin Hamidizadeh; Behrooz Barikbin; Maryam Yousefi; Abbas Sahraei; Ali Khamesipour; Shima Younespour; Hanif Sadeghitehrani
Volume 14, Issue 2 , 2011, , Pages 48-51
Abstract
Introduction: Cutaneous Leishmaniasis (CL) is a parasitic disease caused by Leishmania species. Currently accessible treatments remain insufficient, and there is pressure to develop suitable and effectual options. In this study, we used different concentrations of podophyllin in vitro on leishmania parasites ...
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Introduction: Cutaneous Leishmaniasis (CL) is a parasitic disease caused by Leishmania species. Currently accessible treatments remain insufficient, and there is pressure to develop suitable and effectual options. In this study, we used different concentrations of podophyllin in vitro on leishmania parasites and then on leishmaniasis lesions in mice and compared their efficacy. Method: We used podophyllin (14.3 µg/ml) in vitro against leishmania major parasites, then in experimental animals in different concentrations. Results: Podophyllin (14.3 µg/ml) that used in vitro eradicated leishmania major parasites, but, in mice after four weeks was not effective and the diameter of the lesions increase with use of topical podophyllin. Conclusion: Despite the lethal effect on leishmania in vitro, treatment with different doses of podophyllin could not accelerate the healing process of the leishmaniasis lesions of the experimental rats.