Nasrin Saki; Mina Bazyar Sarani; Fatemeh Sari Aslani; Mohammad Mahdi Parvizi
Abstract
Primary cutaneous diffuse large B‐cell lymphoma-leg type (PCDLBCL‐LT) is a rare malignant disease seen in older adults, especially women. In this case report, we discuss a 78-year-old man who developed erythematous indurated plaques on his left shin for about three months. The patient did not report ...
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Primary cutaneous diffuse large B‐cell lymphoma-leg type (PCDLBCL‐LT) is a rare malignant disease seen in older adults, especially women. In this case report, we discuss a 78-year-old man who developed erythematous indurated plaques on his left shin for about three months. The patient did not report pruritus, weight loss, night sweats, fever, or chills. There was no lymphadenopathy, splenomegaly, or hepatomegaly on the physical examination. A local tissue biopsy was taken from the plaques, confirming the diagnosis of PCDLBCL‐LT via immunohistochemistry. The patient was referred to an oncologist to begin additional evaluation and treatment. According to the literature, chemotherapy with or without adjuvant radiotherapy is the first treatment choice for PCDLBCL‐LT. Monotherapy with rituximab could be considered in some patients with this condition, but the disease may relapse in a short period.
Nasrin Saki; Fatemeh Sari Aslani; Mohammad Javad Najafzadeh; Roya Radanfar; Seyed Ali Hosseini; Najmeh Ahramiyanpour
Mohammad Mahdi Parvizi; Mahshad Shabani; Nasrin Saki; Shirin Rajabi; Thomas Rampp; Mehdi Pasalar
Abstract
Background: Functional dyspepsia (FD) is a common disorder of the upper gastrointestinal tract. Several documents in conventional medicine claim an association between FD, sleep disturbance, and some dermatological conditions, but there is still debate about these relationships. This study aimed to measure ...
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Background: Functional dyspepsia (FD) is a common disorder of the upper gastrointestinal tract. Several documents in conventional medicine claim an association between FD, sleep disturbance, and some dermatological conditions, but there is still debate about these relationships. This study aimed to measure the association between FD and some skin problems and sleep indices based on the attitudes of traditional Persian medicine.
Methods: This study was carried out on patients with the diagnosis of FD and healthy people. The study populationconsisted of patients who referred to the gastroenterology clinic of Shiraz University of Medical Sciences (Shiraz, Iran) from July to December 2019. To diagnose dyspepsia, we used Rome III criteria. Skin problems and sleep indices were evaluated using a validated researcher-made questionnaire. P-values of ≤0.05 were considered significant.
Results: Overall, 160 patients (46 men and 116 women) with FD and 155 healthy individuals (36 men and 119 women) were enrolled in the study. There were significant differences between patients and healthy individuals in terms of dryness of skin (P = 0.001), oily hair, deep sleep, long sleep, insomnia, difficulty sleeping, and nightmares (p≤0.001). On the other hand, there were no significant differences between the groups in intermittent sleeping (P = 0.116) and periorbital edema after sleeping (P = 0.195).
Conclusions: According to the results of this study, it seems that there is a positive relationship between FD and some dermatological and sleeping indices based on traditional Persian medicine resources.
Alireza Heiran; Farhad Handjani; Nasrin Saki; Maryam Rezaee
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic and possesses a tropism for multiple organs.
In this systematic review, we put together all relevant papers to assess the link between COVID-19 infection and acral ...
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic and possesses a tropism for multiple organs.
In this systematic review, we put together all relevant papers to assess the link between COVID-19 infection and acral lesions (particularly chilblain-like lesions) and to determine whether these lesions can be put together in a spectrum of manifestations.
Skin manifestations of COVID-19 vary, ranging from mostly acral chilblain-like, livedoid lesions or ischemia and necrosis to vesicular eruptions, maculopapular lesions, urticaria, oral or periorbital lesions, and drug eruptions.
A great deal of scientific evidence have focused on the peculiar erythematous and purpuric violaceous acral
lesions in young and healthy individuals resembling chilblains (pernio), leading the scientific community to investigate the association between these lesions and SARS-CoV-2. Furthermore, this is suggestive that some COVID-19 skin manifestations like livedo reticularis and acral ischemia and necrosis might share
dermatopathologic features with thrombophilic states.
Mohamad Reza Namazi; Nasrin Saki; Maryam Hadibarhaghtalab
Fatemeh Sari Aslani; Nasrin Saki; Mohammad Sasannia
Abstract
Background: Since its recognition, frontal fibrosing alopecia (FFA) has increasingly been studied globally in terms of its diverse aspects. Having found no studies describing this condition in Southern Iran, we examined the different clinicopathological features of patients with FFA who referred to Faghihi ...
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Background: Since its recognition, frontal fibrosing alopecia (FFA) has increasingly been studied globally in terms of its diverse aspects. Having found no studies describing this condition in Southern Iran, we examined the different clinicopathological features of patients with FFA who referred to Faghihi Hospital, Southern Iran, between 2013 and 2018. Methods: We searched the archives of the Pathology Department of Faghihi Hospital for the cases with a diagnosis of FFA. Due to its similar histopathologic features with lichen planopilaris, the final diagnosis was made using clinical correlations. Results: Twenty-two patients were enrolled; all were female. Fifteen (68.2%) presented with the disease before menopause. Besides frontal and/or temporal hairline involvement in all the patients, eyebrow alopecia, eyelash loss, body hair loss, and facial papules were present in 81.8%, 27.3%, 50%, and 68.2% of them, respectively. Dermoscopic findings included follicular opening loss (100%), honeycombing of the scalp (81.8%), multiple white dots (77.3%), perifollicular erythema (63.6%), and perifollicular scales (59.1%). The histopathologic examination revealed follicular dropout (95.4%), perifollicular lymphocytic infiltration in the infundibulum and isthmus of the follicles (81.8%), perifollicular fibroplasia (77.3%), intact interfollicular epidermis (59.1%), mild perivascular lymphocytic infiltration in the upper dermis (54.5%), and apoptotic keratinocytes in the infundibulum and isthmus (50%). The most common comorbidity was hypothyroidism (40.9%). Conclusions: Thediagnosis of FFA should be considered in both premenopausal and postmenopausal women. Eyebrow alopecia, eyelash loss, body hair involvement, and facial papules are helpful clues in the diagnosis. The coexistence of hypothyroidism with FFA suggests immunological involvement in the pathogenesis.
Farhad Handjani; Nasrin Saki; Motahareh Hosseini; Taraneh Tadayon
Volume 20, Issue 3 , 2017, , Pages 84-88
Abstract
Background: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are 2 inflammatory indicators that increase in many pathologic and physiologic conditions. Pemphigus vulgaris (PV) is an autoimmune skin disease in which autoantibodies against desmogleins cause acantholysis. In this study ...
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Background: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are 2 inflammatory indicators that increase in many pathologic and physiologic conditions. Pemphigus vulgaris (PV) is an autoimmune skin disease in which autoantibodies against desmogleins cause acantholysis. In this study we have measured ESR and CRP levels in patients with PV to evaluate the relationship between an increase in these markers and disease severity.Methods: In this cross-sectional study, we selected patients with proven diagnosis of PV who referred to the Dermatology referral clinic, Faghihi hospital, Shiraz, Iran during a one year period. There were 30 patients enrolled in this study who provided blood samples to measure their ESR and CRP levels. We usedthe Mahajan scoring system to determine the disease severity. Results: In 27 (90%) cases, ESR was normal and 20 (66.7%) cases had negative CRP. There was a significant correlation between CRP and PV severity (P=0.015); however, there was no correlation between ESR and disease severity (P=0.126). Conclusion: A correlation existed between CRP and severity of PV. Further studies must be undertaken to prove the prognostic role of CRP in PV. The discovery of new prognostic factors can change the treatment strategy and protocol for PV.
