Ramin Radmanesh; Mohammad Radmanesh
Abstract
Background: There is no cure for xeroderma pigmentosum (XP) patients who suffer from persistent freckling and recurrent lifethreatening malignancies. We aimed to remove facial lentiginous pigmentations using CO2 laser resurfacing.Methods: 5 patients with clinically proven XP living in their third decade ...
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Background: There is no cure for xeroderma pigmentosum (XP) patients who suffer from persistent freckling and recurrent lifethreatening malignancies. We aimed to remove facial lentiginous pigmentations using CO2 laser resurfacing.Methods: 5 patients with clinically proven XP living in their third decade were scheduled to be treated with CO2 laser resurfacing. After tumescent anesthesia, the whole facial skin was treated with 3 UltraPulse® conventional CO2 ablation passes. The parameters used were 6 mJ, 5 mJ, and 4 mJ for the first to third passes. The mandibular areas were treated with two passes of 4 and 3.2 mJ, while the eye contours were treated with two passes of 3.6 mJ and 3.2 mJ.Results: The face was edematous and almost free of freckling immediately after resurfacing. The edema persisted for a week. The facial skin oozed within the first three days, followed by crust formation. After a week and after complete shedding of the crusts, smooth and erythematous skin appeared. The erythema persisted for more than two months. The patients were free of malignancy and freckling for up to 16 months follow-up.Conclusion: CO2 laser can remove lentiginous pigmentation and prevent or postpone malignancies for a considerable length of time.
Ramin Radmanesh; Mohammad Radmanesh
Abstract
Lichen planus pigmentosus (LPP) develops as an asymptomatic and dusky pigmentation of the facial skin with no effective treatment. Herein we report a 54-year-old lady with clinical and histopathologic confirmation of LPP who was scheduled to be treated with CO2 laser resurfacing. ...
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Lichen planus pigmentosus (LPP) develops as an asymptomatic and dusky pigmentation of the facial skin with no effective treatment. Herein we report a 54-year-old lady with clinical and histopathologic confirmation of LPP who was scheduled to be treated with CO2 laser resurfacing. After tumescent anesthesia, the whole facial skin was treated with three passes of Ultrapulse conventional CO2 ablation. The energy used in the first, second, and third passes were 6.6, 5.4, and 4.8 mJ, respectively. The mandibular area was treated with two passes (4.2 and 3.6 mJ). The eye contours were treated with two passes (3.9 and 3.3 mJ). The patient’s face remained edematous for a week, with the facial skin oozing within the first three days before it became crusted. The crust shed out from day three to six. After a week, smooth and erythematous skin appeared. The erythema persisted for up to four months, after which uniform skin with considerable bleaching and rejuvenation developed. No recurrence occurred within 18 months of follow-up. We conclude that LPP can be treated with CO2 laser resurfacing without any complications.
Mohammad Radmanesh; Nasibeh Sohrabian; Ramin Radmanesh
Volume 16, Issue 4 , 2013, , Pages 159-161
Abstract
The patients with universal vitiligo and residual pigmented patches usually do not benefit from available repigmenting methods and are better scheduled for depigmentation by medical, laser,and or freezing procedures. A 37-year-old lady with universal vitiligo and remaining pigmentation ...
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The patients with universal vitiligo and residual pigmented patches usually do not benefit from available repigmenting methods and are better scheduled for depigmentation by medical, laser,and or freezing procedures. A 37-year-old lady with universal vitiligo and remaining pigmentation in the left anterior chest wall, both ventral forearms, and diffuse mottled depigmentation of the face was scheduled for facial depigmentation by 532 nm Q-switched Nd-YAG laser. All residual pigmented facial areas were treated uniformly. Two months after laser therapy, we paradoxically observed considerable repigmentation of the treated areas with only some remaining scattered and round depigmented patches. Through an unknown mechanism, a true reverse Koebner phenomenon with its resultant repigmentation rather than depigmentation was observed in our patient.
Mohammad Radmanesh; Ramin Radmanesh
Volume 16, Issue 1 , 2013, , Pages 17-20
Abstract
Background: Although cryotherapy has been reported as atechnique for depigmenting residual pigmented patches inpatients with universal vitiligo, Q-switched Nd-YAG lasershave not yet been used for this purpose. The aim of this studywas to compare the efficacy of cryotherapy with that of 532nmQ-switched ...
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Background: Although cryotherapy has been reported as atechnique for depigmenting residual pigmented patches inpatients with universal vitiligo, Q-switched Nd-YAG lasershave not yet been used for this purpose. The aim of this studywas to compare the efficacy of cryotherapy with that of 532nmQ-switched Nd-YAG laser therapy for depigmentation in patientswith universal vitiligo.Method: Six adult patients (4 male and 2 female) with universalvitiligo and facial residual pigmented patches were treatedsimultaneously with cryotherapy on the right and the frequencydoubled532nm Q-switched Nd-YAG laser therapy on the leftside. The laser parameters used were spot size 3-5mm, frequencyrate 10 hertz, and the fluence was 5J/cm2. The cryo system wasa closed contact CO2 Cryo gun. The patients were scheduled tobe treated monthly.Result: The depigmentation was complete after three successivesessions of cryotherapy and 30-45 days after the last session, incomparison with simultaneous 30-70% depigmentation of the laserside. No scar or permanent sequellae developed on either side.Conclusion: Cryotherapy is more effective and fast-actingthan Q-switched Nd-YAG laser for depigmentation of residualpigmented patches in patients with universal vitiligo.