zeinab Aryanian; Mohammad Keramatipour; Nafiseh Esmaili; Azadeh Goodarzi; Arghavan Azizpour; Ifa Etesami; Maede Rayati Damavandi; Ghazaleh Zarrinrad; Somayeh Ahmadloo; Narges Ghandi
Abstract
Background: Pemphigus vulgaris (PV) is an autoimmune bullous disease of the skin and mucous membranes caused by activation and proliferation of T cells, production of Th2 cytokine profile and pathogenic antibodies. Vitamin D is a probable immunodeviator to Th2, which its actions are ...
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Background: Pemphigus vulgaris (PV) is an autoimmune bullous disease of the skin and mucous membranes caused by activation and proliferation of T cells, production of Th2 cytokine profile and pathogenic antibodies. Vitamin D is a probable immunodeviator to Th2, which its actions are mediated through the vitamin D receptor (VDR). FokI is the only single nucleotide polymorphism (SNP) leading to VDR protein with a different structure and function. For the first time, we focused on FokI VDR SNP to evaluate its potential role in the genetic susceptibility to PV, particularly in the Iranian population that has a high prevalence of pemphigus.Methods: In this case-control study, DNA samples of 122 PV patients and 233 healthy controls were extracted, and FokI genotyping was performed using the PCR-RFLP method.Results: The mean allele frequencies of F and f alleles in the PV and control groups were 75% and 25%, and 78% and 22%, respectively, showing no significant difference. The genotype frequencies for FF, Ff, and ff genotypes in the case group were 57.4%, 35.2%, and 7.4%, respectively. In the control group, the frequencies were 60%, 36%, and 4%, respectively. Statistical analysis showed no significant difference between the two groups.Conclusion: The present study concluded the frequencies of F and f alleles as approximately 77% and 23% in the gene pool of the Iranian population. Additionally, it showed no association between the FokI alleles and PV in this population.
Arghavan Azizpour; Zeinab Aryanian; Azita Nikoo; Maryam Nasimi; Azadeh Goodarzi; Ifa Etesami
Abstract
Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is known as an uncommon disorder of keratinization in which acrosyringium is involved; however, its causes have yet remained unknown. It is presented clinically by discrete keratotic papules on distal extremities arranged ...
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Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is known as an uncommon disorder of keratinization in which acrosyringium is involved; however, its causes have yet remained unknown. It is presented clinically by discrete keratotic papules on distal extremities arranged in a linear pattern along Blaschko lines. Histopathologically, it is characterized by cornoid lamella, which is almost always located overlying an acrosyringium. We present a case with an unusual presentation of extensive PEODDN lesions along the lower extremity. Our case was a young woman presented with multiple keratotic elevated papules on her left sole since her birth. In continuity with the lesions on her sole, a linear plaque was extended up to her buttock. Histopathology showed hyperkeratosis with cornoid lamella overlying the acrosyringium. The rarity of PEODDN and interesting presentation of the lesions on the sole of our patient with extension in a linear Blaschko pattern up to her buttock resembling verrucous linear epidermal nevus encouraged us to present this case.
Zeinab Aryanian; Hosein Shahabandaz; Meysam Abdollahzadeh Sangrody; Azar Shirzadian; Soodabeh Tirgartabari; Ali Bijani; Shabnam Fahim; Ifa Etesami; Arghavan Azizpour; Azadeh Goodarzi
Abstract
Background: Lichen planus is a chronic inflammatory disease associated with an increased risk of subclinical atherosclerosis and cardiovascular diseases. This study aimed to evaluate patients with lichen planus using carotid Doppler ultrasound parameters.Methods: Forty patients with lichen ...
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Background: Lichen planus is a chronic inflammatory disease associated with an increased risk of subclinical atherosclerosis and cardiovascular diseases. This study aimed to evaluate patients with lichen planus using carotid Doppler ultrasound parameters.Methods: Forty patients with lichen planus and 40 controls were included in this study. Common carotid artery intima-media thickness (CIMT) and the number of atherosclerotic plaque weremeasured and compared to the control group. Total cholesterol, triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured. Leptin level (Pg/ml)was measured using the enzyme-linked immunosorbent assay (ELISA) method (Leptin ELISA kit, Orgenium, Finland).Results: Significant difference was found between the groups in terms of CIMT (P=0.005). The median range for blood leptin level, triglyceride, cholesterol, and LDL was higher for lichen planus patients than for controls. We found a significant difference between the severity of LP and CIMT (P=0.035). No statistical difference was found between LP and the number of atherosclerotic plaque.Conclusions: Our study suggested that measurement of the mean intima media wall thickness of the common carotid artery could be beneficial as a valuable method for early diagnosis of atherosclerosis in lichen planus.
Maryam Nasimi; Arghavan Azizpour; Robabeh Abedini; Alireza Ghanadan
Volume 20, Issue 2 , 2017, , Pages 59-62
Abstract
Morphea is an autoimmune connective tissue disease of the dermis and subcutaneous fat characterized by sclerosis due to excessive collagen deposition. Morphea is classified into different subtypes based on clinical and histological characteristics of cutaneous lesions. An extremely rare subtype of morphea ...
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Morphea is an autoimmune connective tissue disease of the dermis and subcutaneous fat characterized by sclerosis due to excessive collagen deposition. Morphea is classified into different subtypes based on clinical and histological characteristics of cutaneous lesions. An extremely rare subtype of morphea is termed unilateral generalized morphea (UGM). UGM is characterized by indurated plaques on dermatomes of the trunk or back with a sharp midline demarcation line. Ipsilateral limbs may also be affected. There is still debate on whether this type of morphea should be considered as a distinct type or a presentation of linear morphea. Here we report the case of an 8-year-old boy with this type of morphea.