Zahra Asadi-Kani; Soheila Nasiri; Parvaneh Vessal; Zohreh Tehranchinia; Majidreza Haghzare; Marjan Saeedi
Volume 15, Issue 1 , 2012, , Pages 4-6
Abstract
Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in ...
Read More
Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in the benign melanocytic lesions. Method: Twenty-one patients, 11 with cutaneous melanoma and 10 with benign melanocytic lesions were enrolled in this study. Estrogen receptor beta expression in benign melanocytic lesions and melanoma was analyzed by using immunohistochemical staining. Result: All melanocytic lesions expressed estrogen receptor beta protein. We found lower estrogen receptor beta protein levels in melanoma. Conclusion: These initial observations, to be confirmed by further comprehensive studies, could suggest a role for estrogen receptor beta in melanoma, pointing at the possibility of using estrogen receptor beta expression for differentiating between malignant and benign lesions.
Soheila Nasiri; Marjan Saeedi
Volume 13, Issue 2 , 2010, , Pages 62-63
Abstract
A 40-year old woman was visited at our clinic with a history of palpable purpura appearing after alexandrite laser (Apogee 5500 Alex, 15mm spot shot, 755 nm wave length, 18 j/cm2 fluence) hair removal. The skin lesions were located bilaterally on the lower extremity (Figure1). Other physical examinations ...
Read More
A 40-year old woman was visited at our clinic with a history of palpable purpura appearing after alexandrite laser (Apogee 5500 Alex, 15mm spot shot, 755 nm wave length, 18 j/cm2 fluence) hair removal. The skin lesions were located bilaterally on the lower extremity (Figure1). Other physical examinations were unremarkable. The patient had no history of taking medications, underlying systemic diseases and family history of collagen-vascular diseases. Blood biochemical analysis was normal and all the tests for collagenvascular diseases were negative. The patient declined skin biopsy. After six weeks of conservative therapy, the purpura faded. Laser-assisted hair removal has recently become popular. The number of lasers and light sources currently available for hair removal and their various treatment protocols has created much confusion; but, the fact is that all photoepilation systems target follicular melanin. Therefore, all hair removal devices provide a significant opportunity for epidermal and dermal injury during the epilation process 1. Alexandrite laser system can produce a number of side effects including transient erythema, perifollicular edema, treatment pain, hyperpigmentation, hypopigmentation and crusting 2,3. Other rare side effects of this laser are folliculitis, erosions and purpura 1. The extent of these complications is determined by skin type, seasonal variations, and patient's history of recent sun exposure. Complication rates also vary according to the anatomic location treated. The extremities are most commonly affected. Blistering, fine epidermal crusting, hypopigmentation and purpura are experienced more commonly in darker skin tones (phototypes III and higher) or in tanned skin 1. The prominent point of our report was the appearance of purpura in a patient with skin phototype II and in a sun protected area. This report indicates that it is essential for the laser operator to be well educated upon the potential risks of photoepilation and to have a thorough understanding of laser-tissue interaction before embarking upon the laser-assisted hair removal process.
Leila Nabai; Mohammad Ebrahimzadeh Ardakani; Mohammad Shahidi Dadras; Soheila Nasiri
Volume 10, Issue 1 , 2007, , Pages 32-36
Abstract
Background and aim: Diabetes mellitus is a metabolic disease with multiple complications. Skin tag is a pedunculated papule, which is more common in women and has been suggested as a cutaneous marker of diabetes mellitus. The aim of this study was to determine the frequency of diabetes mellitus in patients ...
Read More
Background and aim: Diabetes mellitus is a metabolic disease with multiple complications. Skin tag is a pedunculated papule, which is more common in women and has been suggested as a cutaneous marker of diabetes mellitus. The aim of this study was to determine the frequency of diabetes mellitus in patients with skin tags.Materials and methods: This descriptive study was done on 100 patients with skin tags. The investigation included fasting blood sugar (FBS) and glucose tolerance test (GTT).Results: 66 patients had normal FBS, 27 had diabetes mellitus, 5 had impaired GTT and 2 had impaired fasting glucose. Over all, 34 had abnormal glucose metabolism, 7 were unaware of their metabolic abnormality. Among 40 hospitalized patients 50% had abnormal glucose metabolism meanwhile 23.3% of 60 outpatients had this abnormality (p<0.01). No association was seen between BMI, obesity, gender, location and number of skin tags with abnormal metabolism of glucose.Conclusion: It is recommended to consider skin tags as a cutaceous marker for abnormality of glucose metabolism.