Yuichi Kurihara; Keiko Sakamoto-Tanegashima; Mitsuru Kinjo; Takeshi Nakahara; Masutaka Furue
Abstract
Dermoscopy helps detect melanoma on the acral volar skin. A parallel ridge pattern is one of the characteristic dermoscopic findings of melanoma but is also seen in benign lesions, including drug-induced hyperpigmentation. Histological examination is therefore necessary for definitive diagnosis. A 74-year-old ...
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Dermoscopy helps detect melanoma on the acral volar skin. A parallel ridge pattern is one of the characteristic dermoscopic findings of melanoma but is also seen in benign lesions, including drug-induced hyperpigmentation. Histological examination is therefore necessary for definitive diagnosis. A 74-year-old Japanese man was referred to our department with irregular-shaped brown macules on his palms and soles. The pigmented lesions had a parallel ridge pattern on dermoscopic examination. The largest lesion was resected at the patient’s insistence and considering the possibility of melanoma. Histopathological examination revealed increased melanin granules in basal keratinocytes and many melanophages in the superficial dermis, especially underlying the crista profunda intermedia, agreeing with the dermoscopic findings. The patient had been receiving tegafurgimeracil- oteracil (TS-1) for advanced gastric cancer. The pigmented lesions gradually regressed after cessation of TS-1, consistent with TS-1-induced hyperpigmentation. Further studies are needed to elucidate the pathogenesis, including analyses of the relationship between acrosyringeal endothelin-1 expression and the presence of volar melanocytes in relation to potential drug metabolism.
Elham Behrangi; Azadeh Goodarzi; Amir Heydarian; Mohammadreza Ghasemi; Zahra Azizian; Parvaneh Hassani; Behrad Dalvand; Nima Hajiha
Abstract
Background: Among different treatments for periorbital hyperpigmentation (POH), both semi-invasive protocols of fractional CO2 laser and platelet-rich plasma (PRP) are favored among clinicians and rarely cause complications; however, the level of patients’ satisfaction seems to differ across these ...
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Background: Among different treatments for periorbital hyperpigmentation (POH), both semi-invasive protocols of fractional CO2 laser and platelet-rich plasma (PRP) are favored among clinicians and rarely cause complications; however, the level of patients’ satisfaction seems to differ across these methods.Methods: This randomized clinical trial was conducted on 100 patients (98 women; 2 men) between 28 to 62 years of age who complained of POH and referred to the Dermatology Clinic of Rasool Akram Medical Complex located in Tehran in 2017. The patients were randomly assigned to two groups receiving fractional CO2 laser (group C) and adding PRP treatments plus laser therapy (group CP). The outcome of both treatment protocols was followed 3 and 6 months after the last treatment by standard photography.Results: The time for swelling after treatment in the C and CP groups was 4.58 ± 0.61 days and 2.94 ± 0.68 days, respectively, which was significantly shorter in group CP (P < 0.001). The mean time for erythema disappearance was also shorter in group CP (5.20 ± 0.76 days vs. 3.40 ± 0.76 days, P < 0.001). Regarding the trend of the change in the ΔE parameter, it fell significantly in both groups within the follow-up period (P < 0.001); however, the mean ΔE was significantly higher in the CP group when compared with the control group (P < 0.001). There were no significant or resistant side effects in either treatment group.Conclusion: Although both therapies are effective and safe, the concurrent use of CO2 laser and PRP can more effectively reduce the severity of POH with a shorter duration of post-treatment swelling and erythema. Hence, this combination is a superior modality for the treatment of POH as compared to laser therapy alone.
Armaghan Gharehaghaji Zare; Afsaneh Radmehr; Faranak Ghasemi
Abstract
H syndrome is an autosomal recessive genodermatosis with reports dating back to the last decade. This syndrome is caused by mutations in the SCL29A3 gene. The clinical characteristics of this syndrome consist of dermatological manifestations, including hyperpigmented, hypertrichotic, ...
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H syndrome is an autosomal recessive genodermatosis with reports dating back to the last decade. This syndrome is caused by mutations in the SCL29A3 gene. The clinical characteristics of this syndrome consist of dermatological manifestations, including hyperpigmented, hypertrichotic, and indurated patches and plaques. It affects various systems by causing heart anomalies, hepatosplenomegaly, hypogonadism, and low height. This is the case of a 19-year-old girl from the northwest of Iran who was born of a cousin marriage. The primary manifestations included low height, underdeveloped secondary sex characteristics, and typical dermatological manifestations. This patient was examined mostly because of digestive and endocrine problems and thus had not been subject to extensive dermatological examinations until the skin biopsies mirrored manifestations similar to histiocytoses (e.g., Rosai-Dorfman disease and granuloma annulare). The patient was eventually diagnosed with H syndrome by a dermatologist from the clinical symptoms. H syndrome is an autosomal recessive genodermatosis that affects different organs and is diagnosed by a set of typical and systemic cutaneous symptoms and biopsies. In this patient, an endoscopic examination of the upper gastrointestinal tract was carried out due to reports of anemia. A biopsy of the atrophic duodenum region revealed the existence of coeliac disease. However, the comorbidity of coeliac disease and H syndrome has not been previously reported.
Bordera Gabriel Buendia; Parada Jorge Gaviria; Giménez Maribel Marti; Pérez Maria de los Llanos; Morell Jiuia Oliva; Marmol Gregorio Viera
Abstract
The use of high-power diode laser with a wavelength of 755 nm is an effective and safe method for the correction and partial and/or total elimination of pigmented lesions, specifically solar lentigines. This wavelength has yet not been used in diode lasers to treat solar lentigines. Side effects are ...
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The use of high-power diode laser with a wavelength of 755 nm is an effective and safe method for the correction and partial and/or total elimination of pigmented lesions, specifically solar lentigines. This wavelength has yet not been used in diode lasers to treat solar lentigines. Side effects are the usual ones, including darkening and scab formation. Our patient was a 40-year-old woman of Caucasian origin and IV Fitzpatrick phototype, who presented with solar lentigines of different sizes and clear edges. The applied treatment was a high-power diode laser of 755 nanometer (nm), 21 millisecond (ms) long pulse and 25 J/cm2 fluence. Initially, the darkening of the lesion occurred, followed by the appearance of a scab, which remitted 10 days after. The use of high-power diode laser of single pulse at 755nm, 25J/ cm2 and 21ms, proved effective and safe concerning the removal of benign pigmented lesions.
Toossi Parviz; Ershadi Sarah; Abolhasani Ehsan
Volume 16, Issue 4 , 2013, , Pages 162-164
Abstract
Universal acquired melanosis is a rare cause of diffuse hyperpigmentation of skin and mucosa during childhood. There are only few reported case of this scarce syndrome in medical literature. We report the first case of universal acquires melanosis from Iran in a 4-year-old girl whose skin becomes darker ...
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Universal acquired melanosis is a rare cause of diffuse hyperpigmentation of skin and mucosa during childhood. There are only few reported case of this scarce syndrome in medical literature. We report the first case of universal acquires melanosis from Iran in a 4-year-old girl whose skin becomes darker after 2-month of age.
AH Ehsani; N Ghandi; Sh Yazdanian; F Farahani
Volume 9, Issue 2 , 2006, , Pages 185-188
Abstract
Becker's naevus is an acquired persistent asymmetrical area of skin pigmentation, sometimes showing evidence of increased androgen sensitivity, and colocalizing with other developmental anomalies. We report a 30-year-old woman with clinical findings compatible with Becker's naevus on her right breast ...
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Becker's naevus is an acquired persistent asymmetrical area of skin pigmentation, sometimes showing evidence of increased androgen sensitivity, and colocalizing with other developmental anomalies. We report a 30-year-old woman with clinical findings compatible with Becker's naevus on her right breast accompanied with hypoplasia of ipsilateral breast.