Rezazadeh Fahimeh; Salah Shilan; Bahareh Nazemi Salman; Ebrahim Shahdadi
Volume 19, Issue 2 , 2016, , Pages 40-44
Abstract
Background: Recurrent aphthous stomatitis (RAS) is among the most common oral lesions and pain is often the chief complaint of patients. The main etiology of RAS is unknown but several predisposing factors have been suggested. This study aims to assess the correlation of blood types (ABO/Rh) with RAS. ...
Read More
Background: Recurrent aphthous stomatitis (RAS) is among the most common oral lesions and pain is often the chief complaint of patients. The main etiology of RAS is unknown but several predisposing factors have been suggested. This study aims to assess the correlation of blood types (ABO/Rh) with RAS. Methods: We conducted this prospective screening study on 50 patients with RAS and 50 controls. Both groups received a questionnaire and underwent serum screening for detection of blood t
Rashidi Touraj; Mahd Azarmdokht Alamdari
Volume 9, Issue 4 , 2006, , Pages 350-354
Abstract
Background and aim: Recurrent aphthous stomatitis is a relapsing disease with typical ulcers that involve the oral mucosa. The objective of this study was to determine the microbial flora and pH of mouth in patients during and between disease relapse.Materials and Methods: Patients were selected by simple ...
Read More
Background and aim: Recurrent aphthous stomatitis is a relapsing disease with typical ulcers that involve the oral mucosa. The objective of this study was to determine the microbial flora and pH of mouth in patients during and between disease relapse.Materials and Methods: Patients were selected by simple non-random sampling. Totally 28 patients were included in this study. After filling out a questionnarie, patients were referred to the laboratory and a sample from oral ulcer was obtained and cultured in both aerobic and anaerobic media. PH of mouth was measured by pH meter. Same process was repeated two weeks after remission.Results: Considering non-group A Streptococci and gram positive bacteria, there were no changes in oral flora culture in aerobic environment in relapse and remission time. Staphylococcus aureus growth was seen in aerobic environment in 3(10.7%) patients in relapse and in 2 (7.1%) in remission which was not statistically significant. There were not considerable changes in group A Streptococci in remission and relapses and also in gram negative bacilli. But in anaerobic cultures there was considerable increase of non-group A Streptococcus in relapse and remission (71/4%, in relapse and 39.3% in remission, P<0.01). There were not specific changes in other bacteria. There was higher oral pH in 53.3% of patients, lower pH in 20% and no change in pH in 26.7% of patients during active phase of disease.Conclusion:There is considerable increase in non-A Streptococcus and increasing oral pH in majority of patients with aphthous stomatitis in relapse time.
T Rashidi; A Alamdari Mahd; A Hamzeh Zadeh; R Talebi
Volume 7, Issue 3 , 2004, , Pages 152-155
Abstract
Background: Recurrent aphthous stomatitis (RAS) is a common disease, which several etiologic factors have been considered for it. The infectious agents and immunological factors are the most suspected causes. Recently a few studies with varied results have been done to clarify the role of Helicobacter ...
Read More
Background: Recurrent aphthous stomatitis (RAS) is a common disease, which several etiologic factors have been considered for it. The infectious agents and immunological factors are the most suspected causes. Recently a few studies with varied results have been done to clarify the role of Helicobacter Pylori (H.pylori) in etiology of RAS. Objective: To find correlations between serum IgG and IgA levels to Helicobacter Pylori and RAS. Patients & methods: A total number of 29 patients with RAS referred to Urmia skin hospital were included in this case-control study. Control group consisted of 57 persons and was chosen from healthy individuals. Blood samples were taken and blood levels of IgG and IgA antibodies of patients and control were measured by ELISA method and collected data were analyzed by chi-square test. Results: IgG antibodies to H.pylori were found in the sera of 75.9% of RAS patients and 66.7% of controls. IgA antibodies were detected in 51.9% of RAS and 70.9% of controls. These differences were not statistically significant. Conclusion: There was no significant difference between IgG and IgA levels to Helicobacter Pylori in patients with RAS compared to control group.
M Shahidi Dadras; H Naseh Ghafoori; L Gachkar
Volume 6, Issue 4 , 2003, , Pages 3-10
Abstract
Background: The current treatments of recurrent aphthous stomatitis are not very effective and are not justified for long term using due to their potential side effects. Objective: To compare the efficacy of topical sucralfate mouthwash with topical tetracycline mouthwash in recurrent aphthous stomatitis. ...
Read More
Background: The current treatments of recurrent aphthous stomatitis are not very effective and are not justified for long term using due to their potential side effects. Objective: To compare the efficacy of topical sucralfate mouthwash with topical tetracycline mouthwash in recurrent aphthous stomatitis. Patients and Methods: In a randomized matched clinical trial, 60 patients with recurrent aphthous stomatitis fulfilling our inclusion criteria, referred to skin clinics affiliated to Skin Research Center in Shahid Beheshti University of Medical Sciences in 1380-81 were assessed. The patients were randomly divided in two groups, matched for age and type of the ulcer. The case group (26 patients) used a mouthwash containing 1gr sucralfate per 15cc, and the control group (34 patients) used a mouthwash containing 250mg tetracycline per 15cc, four times a day and were assessed every 2 weeks. The data were analyzed by chi-square and t-tests (P<0.05). Results: There were no significant difference between two groups regarding the frequency, healing time and pain of the aphthous lesions. Patients were more satisfied with the sucralfate suspension than tetracycline suspension in the end of treatment period (P<0.03) and in the end of follow up period (P<0.04). No side effects were seen in two group. Conclusion: Sucralfate suspension mouthwash can be considered equally effective as tetracycline mouthwash in treating recurrent aphthous stomatitis. It can be considered as a special modality for aphthous ulcer treatment due to lack of systemic toxicity and side effects even if accidentally swallowed or absorbed through mucosal surfaces.