Ali Asilian; Zabihollah Shahmoradi; Shahryar Rahmani; Hossein Hafezi; Samaneh Mozafarpoor
Abstract
Background: Bleomycin is used for the treatment of warts. However, only its injected form can be used due to systemic use side effects, and plantar warts have a high recurrence rate following administration of bleomycin tattooing alone. To find an effective alternative with fewer side effects, we decided ...
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Background: Bleomycin is used for the treatment of warts. However, only its injected form can be used due to systemic use side effects, and plantar warts have a high recurrence rate following administration of bleomycin tattooing alone. To find an effective alternative with fewer side effects, we decided to investigate the effectiveness of bleomycin tattooing combined with trichloroacetic acid (TCA) and shaving in the management of treatment-resistant plantar warts.
Methods: The patients with treatment-resistant plantar warts entered the present quasi-experimental study. the wart site was shaved ahead of bleomycin tattooing and TCA peeling. This treatment was provided at one-month intervals and was repeated a maximum of four times. Patients were followed for six months after completion of the therapy. Finally, the patients’ data were completed according to photographs (monthly photos taken of lesions) and careful examinations.
Results: The present study involved 56 patients with a mean age of 25.75 ± 12.22 years. Twelve patients (21.4%) recovered after the first treatment; 14 (25%) needed the second treatment, 12 (21.4%) needed the third, 10 (17.9%) the fourth, and eight (14.3%) did not recover after the fourth treatment. The recovery rate was 21.4% with one, 45.4% with two, 66.8% with three, and 85.7% with four treatment sessions.
Conclusion: The combination treatment of bleomycin plus TCA and shaving led to a remarkable recovery from treatment-resistant plantar warts (21.4% recovery with the first treatment session and up to 85.7% recovery after four sessions). The treatment included tattooing and local injections, leaving few side effects.
Amruta P. Dhotre; Sudhir P. Singh; Bhushan Madke; Adarshlata Singh; Sugat Jawade
Abstract
Background: Idiopathic guttate hypomelanosis (IGH) is characterized by discrete, multiple, round-to-oval hypopigmented macules of approximately 2-5 mm diameter, especially on the forearms and pretibial area,which increase in number with aging. Recent focus has been on therapeutic ...
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Background: Idiopathic guttate hypomelanosis (IGH) is characterized by discrete, multiple, round-to-oval hypopigmented macules of approximately 2-5 mm diameter, especially on the forearms and pretibial area,which increase in number with aging. Recent focus has been on therapeutic wounding, which stimulates melanocytes from the periphery and surrounding hair follicles to proliferate, migrate, and repigment the lesions. This study aimed to evaluate and compare the efficacy of trichloroacetic (TCA) 50% application and dermabrasion in IGH patients.Methods: Twenty patients of IGH were enrolled after considering various inclusion and exclusion criteria. IGH lesions over the right side were treated with trichloroacetic acid (TCA) 50% witha cotton-tipped applicator. IGH lesions over the left side were treated with dermabrasion.Results: Of the 153 macules in 20 patients, all 81 macules in the dermabrasion group showed some repigmentation, whereas 7 (9.7%) out of 72 macules treated with 50% TCA Touch™ showedno improvement. At the end of 3 months, repigmentation up to 25%, between 25–50%, and between 51–75% was seen in 18.5%, 66.7%, and 14.8% of lesions treated with dermabrasion, respectively. This is while TCA 50% touch-treated macules showed up to 25% and between 25–50% repigmentation in 48.6% and 41.7% of instances, respectively.Conclusion: The analysis suggested that both dermabrasion and TCA 50% Touch are effective in the treatment of IGH. Dermabrasion proved to be more effective than TCA peel and can be tried before or with the medical line of therapy in the treatment of IGH.
Lotfabadi Pegah; Maleki Farzaneh; Gholami Ali; Yazdanpanah Mohammad Javad
Volume 18, Issue 4 , 2015, , Pages 151-155
Abstract
Background: Cryotherapy is one of the most common and effective treatments of anogenital warts, and trichloroacetic acid is one of the methods commonly used. The aim of this study was to compare the effect of cryotherapy and trichloroacetic acid in the treatment of anogenital warts.Methods: This randomized ...
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Background: Cryotherapy is one of the most common and effective treatments of anogenital warts, and trichloroacetic acid is one of the methods commonly used. The aim of this study was to compare the effect of cryotherapy and trichloroacetic acid in the treatment of anogenital warts.Methods: This randomized clinical trial was conducted on patients with anogenital warts. The patients were divided into two groups; one group was treated with liquid nitrogen and theother with 70% trichloroacetic acid. In both groups, the treatment was done every two weeks until complete disappearance of the lesions or for 6 sessions.Results: In this study, 68 patients with anogenital warts were studied. After the 6th session, the cure rate of in the patients treated with trichloroacetic acid (94.1%) was higher than the patients treated with cryotherapy (85.3%) (P>0.05).Conclusion: It seems that cryotherapy and trichloroacetic acid therapy have similar results in the treatment of anogenital warts.
Zohreh Tehranchinia; Hoda Rahimi; Mansour Moradloo
Volume 13, Issue 3 , 2010, , Pages 82-86
Abstract
Background: Benign pigmented lesions, including freckles, are common and various treatment modalities including lasers and peeling have been evaluated for their effectiveness in their treatment.Objective: To compare the clinical effects of focal peeling with Trichloroacetic Acid (TCA) and Nd:YAG (532 ...
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Background: Benign pigmented lesions, including freckles, are common and various treatment modalities including lasers and peeling have been evaluated for their effectiveness in their treatment.Objective: To compare the clinical effects of focal peeling with Trichloroacetic Acid (TCA) and Nd:YAG (532 nm) laser on freckles.Methods: Twenty patients with freckles were treated with focal peeling with TCA 25% on their left-sided lesions and Nd:YAG (532 nm, Fluence 9.5 J/cm2, spot size 1.5 mm) on their right-sided lesions. Photographs were taken prior to treatment and at follow-up visits and were evaluated by three dermatologists and the results were analyzed.Results: Eighteen out of the 20 patients (90%) with freckles manifested more than 50% improvement in laser treated areas whereas clinical improvement in focal peeling treated areas was observed in 15 out of 20 (75%). The mean improvement rate for laser and focal peeling was 66.50±12% and 58.3±15%, respectively. No significant difference was observed in the treatment results between these modalities.Conclusion: Focal peeling with TCA 25% could be as effective as frequency-doubled Nd:YAG (532 nm) laser in the treatment of freckles.
Farideh Golforoushan; Hamideh Azimi; Mohamad Sadeghi; Neda Yousefi; Mohamad Goldust
Volume 13, Issue 2 , 2010, , Pages 47-50
Abstract
Introduction: Solar lentigo is local and benign proliferation of melanocytes which is common in old individuals and creates a major concern considering beauty. Despite several and somehow expensive treatments such as laser and cryotherapy, chemical peeling with Trichloroacetic Acid (TCA) has recently ...
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Introduction: Solar lentigo is local and benign proliferation of melanocytes which is common in old individuals and creates a major concern considering beauty. Despite several and somehow expensive treatments such as laser and cryotherapy, chemical peeling with Trichloroacetic Acid (TCA) has recently attracted attentions considering its low cost and availability. The present study was designed to compare the efficacy and side effects of Trichloroacetic Acid (TCA) 35% and cryotherapy in the treatment of solar lentigo.Methods: This randomized clinical trial was performed on 35 individuals with solar lentigo on their hands. First, images were taken from both hands. Then, one side was treated with cryotherapy and the other side was treated with TCA 35%, randomly. This treatment was repeated after one month. The imaging was repeated at the end of the second month and both sides were compared with previous images regarding the degree of the improvement (lightening) of the lesions and the resultant side effects. Descriptive statistical methods and 2-chi square relation were used for analyzing data with SPSS 16.Results: The results demonstrated that cryotherapy resulted in more than 50% recovery (lightening >50%) in 60% of the cases which was statistically significant (P<0.05). In contrast, TCA 35% yielded more than 50% recovery in 46% of the cases which was significant, too. Comparing these modes of treatments regarding 50% recovery showed no statistically significant difference (P=0.219). Side effects were seen in 40% and 13.3% of the individuals who used cryotherapy and TCA 35%, respectively, which was statistically significant (P<0.05).Conclusions: According to the findings of the research, TCA 35%, compared to cryotherapy, has similar efficiency but fewer side effects in the treatment of solar lentigo.
Layeh Pouran; Pezeshkpour Fakhr-o-Zaman; Shakeri Mohammad Taghi; Mousavi Sareh
Volume 10, Issue 3 , 2007, , Pages 174-180
Abstract
Background and aim : Genital wart is a common sexually transmitted disease caused by different types of human papilloma virus (HPV). Cryotherapy is one of the most commonly used treatment options. Trichloroacetic acid (TCA) is another therapy commonly used in treatment of genital warts.Materials and ...
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Background and aim : Genital wart is a common sexually transmitted disease caused by different types of human papilloma virus (HPV). Cryotherapy is one of the most commonly used treatment options. Trichloroacetic acid (TCA) is another therapy commonly used in treatment of genital warts.Materials and methods: The objective of his study was to evaluate and compare the efficacy and adverse effects of TCA and cryotherapy (with liquid nitrogen). Sixty female patients with external genital warts were enrolled into this prospective clinical trial. Thirty of them received topical solution of 80% TCA and the other 30 received cryotherapy with liquid nitrogen, once a week, until complete clearance of lesions or a maximum duration of 8 weeks. Results: Twenty-seven patients (93.1%) of those who received up to eight treatments of cryotherapy had complete clearance of their warts, compared with 28 (96.5%) of patients who were treated with TCA (P>0.05). The mean duration for complete clearance was 4.4 weeks for TCA and 5.2 weeks for cryotherapy (P=0.5). Patients who received TCA experienced a significantly greater number of local inflammatory reactions (P=0.01). Conclusion: Both cryotherapy and TCA are effective treatments. In comparison, TCA showed its efficacy earlier during the course compared to cryotherapy. TCA is more likely to cause adverse reactions.
Nilforoushzadeh Mohammad Ali; Haftbaradaran Elaheh; Siadat Amir Hossein
Volume 10, Issue 3 , 2007, , Pages 240-244
Abstract
Cutaneous leishmaniasis is an endemic disease in Iran and there is no curative treatment. The disfiguring scar that remains after it subsides is a major psychologic and emotional problem in these patients. Chronic leishmaniasis is a rare form of this malady which is seen in 5-7 percent of cases. In this ...
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Cutaneous leishmaniasis is an endemic disease in Iran and there is no curative treatment. The disfiguring scar that remains after it subsides is a major psychologic and emotional problem in these patients. Chronic leishmaniasis is a rare form of this malady which is seen in 5-7 percent of cases. In this article we report a 46-year-old man who was refered to us for a large leishmaniasis lesion consisting of a scaling erythematous plaque with several papules on the right side of face and nose. This patient was treated by a combination of systemic Glucantime, 50% trichlroacetic acid and oral fluconazole. Complete resolution was achieved after 4 months.
Raziee Morteza; Balighi Kamran; Shabanzadeh-Dehkordi Hossein; Rabati Reza Mahmoud
Volume 9, Issue 4 , 2006, , Pages 308-312
Abstract
Background and aim: Solar lentigines are common sun-induced benign melanocytic proliferations that present a significant cosmetic problem for many middle- aged and elderly patients. The purpose of this study was to assess the efficacy of cryotherapy in comparison to trichloroacetic acid (TCA) 33% on ...
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Background and aim: Solar lentigines are common sun-induced benign melanocytic proliferations that present a significant cosmetic problem for many middle- aged and elderly patients. The purpose of this study was to assess the efficacy of cryotherapy in comparison to trichloroacetic acid (TCA) 33% on solar lentigines on the back of the hands (SLBH).Materials and Methods: Each hand of 33 patients with SLBH was treated randomly with either cryotherapy or TCA 33% solution. Photographs of the hands were taken prior to and two months following the treatment. Therapeutic response and side-effect were compared using chi-square test.Results: Twenty five patients completed the study. Cryotherapy was more likely to produce substantial lightening of the solar lentigines than TCA 33% solution (P=0.025) but was more painful and took longer to heal. Post inflammatory hyperpigmentation (PIH) was almost equal in two types of treatment. Statistically, better results were seen in lower Fitzpatrick's skin types (P<0.01).Conclusion: Cryotherapy appears to be superior to TCA 33% solution in the treatment of SLBH particularly in lower Fitzpatrick skin types. PIH is the major complication of both particularly in higher Fitzpatrick skin types. Generally, the major criterion for treatment of SLBH with cryotherapy or TCA is Fitzpatrick's skin type.
