Sepaskhah Mozhdeh; Mohammadi Ali; Nabavizadeh Sara Sadat; Faridi Pouya; Babaei Amir Hossein
Abstract
Background: Acne vulgaris is a multi-factorial disease affecting many aspects of life. This study was conducted to compare the efficacy of fenugreek seed extract and oral azithromycin in the treatment of acne vulgaris. Methods: A total of 20 patients with acne vulgaris aged between 12 and 30 years old ...
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Background: Acne vulgaris is a multi-factorial disease affecting many aspects of life. This study was conducted to compare the efficacy of fenugreek seed extract and oral azithromycin in the treatment of acne vulgaris. Methods: A total of 20 patients with acne vulgaris aged between 12 and 30 years old were entered into this 60-day, randomized, placebo-controlled, triple-blind study. The patients were randomly divided into two groups, (permuted block randomization, block size of 4), namely fenugreek and azithromycin groups. All the participants daily received two capsules containing 500 mg hydroalcoholic extract of fenugreek seeds or 125mg azithromycin, for two months. The patients were evaluated after 30 and 60 days from the start of the trial. The participants, investigators (the dermatologists who evaluated clinical responses), and statisticians who analyzed the data were blind for identity and allocation of the treatments. Results: The baseline GAGS scores in azithromycin and fenugreek groups were respectively equal to 19.66 and 23.12, and there was a reduction in both azithromycin (GAGS2=14.33) (P-value=0.019) and fenugreek extract group (GAGS2=22.75) (P-value=0.780) during the experiment. There was a statistically significant difference among the two groups (F= (2, 24) = 3.861, P=0.035). Conclusion: The effect of azithromycin was higher than fenugreek in the treatment of acne vulgaris.
Kavoussi Hossein; Ebrahimi Ali; Ramezani Mazaher; Kavoussi Reza
Volume 18, Issue 3 , 2015, , Pages 140-143
Abstract
Melkersson-Rosenthal syndrome is an uncommon disorder which is presented by a triad of lip swelling, facial nerve palsy, and a fissured tongue. A number of treatments have been reported for this syndrome with variable outcomes. We have reported a 38-year-old female patient with lower lip swelling and ...
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Melkersson-Rosenthal syndrome is an uncommon disorder which is presented by a triad of lip swelling, facial nerve palsy, and a fissured tongue. A number of treatments have been reported for this syndrome with variable outcomes. We have reported a 38-year-old female patient with lower lip swelling and a fissured tongue on clinical examination. She was also suffering from facial nerve paralysis since 8 years ago. A significant improvement of the signs was achieved with a combination of intralesional corticosteroid injection and oral azithromycin. Although our patient showed the triad, she had an atypical clinical course due to the initiation of syndrome with facial nerve palsy, resulting in a delay in definite diagnosis of her disease. The anti-inflammatory and immuno-modulatory effects of azithromycin and the therapeutic properties of the intralesional injection of corticosteroid have an important role in managing this syndrome.
Hamideh Moravvej; Akbar Mousazadeh Halim; Maryam Yousefi; Soudabeh Givrad
Volume 15, Issue 1 , 2012, , Pages 7-10
Abstract
Background: Acne vulgaris is the most common disorder of pilosebaceous unit. Systemic antibiotics are known to be effective in its treatment. We performed this investigation to compare the efficacy of azithromycin with doxycycline in the treatment of acne vulgaris. Method: A twelve-week study was performed ...
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Background: Acne vulgaris is the most common disorder of pilosebaceous unit. Systemic antibiotics are known to be effective in its treatment. We performed this investigation to compare the efficacy of azithromycin with doxycycline in the treatment of acne vulgaris. Method: A twelve-week study was performed on 69 patients with moderate facial acne to compare the efficacy of oral azithromycin with oral doxycycline. Sixty patients completed the study. Patients in the treatment arm one were scheduled to receive 500 mg azithromycin once daily three times a week, and patients in the treatment arm two were instructed to use 100 mg doxycycline daily. All patients administered topical tretinoin cream every other night. Clinical assessment was made at baseline and then every 4 weeks. Result: There were statistically significant improvements in comedones and inflammatory lesion counts in both groups. Neither drug was shown to be more effective than the other. Conclusion: This study indicated that azithromycin had similar efficacy to doxycycline in reducing acne lesions.
Ehsani Amir Hooshang; Toosi Siavash; Noormohamadpour Pedram; Hosseini Mahboubeh; Nazeman Leila
Volume 11, Issue 4 , 2008, , Pages 143-146
Abstract
Background: Pityriasis rosea is an inflammatory skin disorder with a known response to erythromycin. Considering similarities between erythromycin and azithromycin and lesser adverse effects of the latter, in a pilot study, we gave azithromycin to seven patients with pityriasis rosea and observed a noticeable ...
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Background: Pityriasis rosea is an inflammatory skin disorder with a known response to erythromycin. Considering similarities between erythromycin and azithromycin and lesser adverse effects of the latter, in a pilot study, we gave azithromycin to seven patients with pityriasis rosea and observed a noticeable improvement. The aim of this study was to evaluate the efficacy of azithromycin in patients with pityriasis rosea.Methods: A double-blind, placebo-controlled clinical trial was performed in our clinic. Sixty patients over a period of 20 months were alternatively assigned to the treatment group or the placebo group. Patients in the treatment group received azithromycin, 250 mg/day, for 14 days. The response was categorized as complete response, partial response, or no response. All patients were followed up for 2 months.Results: Age at presentation, sex, and average duration of the disease were comparable in both groups. Complete response was observed in 19 patients (63.3 %) in the treatment group and two in the placebo group (p<0.0001).Conclusion: Oral azithromycin is effective in treating patients with pityriasis rosea.
Shizarpour Mohammad; Firooz Alireza; Pazooki Hamidreza; Khiabanloo Samad Rezai
Volume 11, Issue 2 , 2008, , Pages 67-72
Abstract
Background: Acne vulgaris is the most common cause for dermatology visits and is one of the most common diseases that people experience during their lives. Although this disease is not life-threatening, it may affect the life quality of the patients because of developing irreparable complications on ...
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Background: Acne vulgaris is the most common cause for dermatology visits and is one of the most common diseases that people experience during their lives. Although this disease is not life-threatening, it may affect the life quality of the patients because of developing irreparable complications on the skin. Dermatologists are in agreement about topical treatment in the mild to moderate acne vulgaris, but extensive using of tropical antibiotics and drug resistance have decreased their therapeutic benefits. In this study, we tried to compare the therapeutic effects of tropical azithromycin and clindamycin. Methods: This study was designed and performed as a double blind, randomized clinical trial. Thirty two patients with mild to moderate acne were treated with azithromycin and 30 patients, who were matched with the former group based on age, sex and severity of the disease, were treated with clindamycin for 12 weeks and results of their treatment were compared with each other. Results: results of this study showed that ratio of response to treatment and decreasing the grade of the disease and number of nodules, papules and pustules were not significantly different in the first month of the treatment in both groups while just the number of nodules in the group on azithromycin showed more decrease in the last months of treatment in comparison with clindamycin (0.88±0.75 vs. 0.25±0.75, p=0.015). Also, clindamycin had more side effects, but the rate of satisfaction with both drugs were high and showed no difference. In this study, no significant association was found between sex and response to treatment and evaluation of association between age and response to treatment showed a significant reverse association between age and decreasing the number of pustules (p=0.002 , r= - 0.492). Conclusion: sum of findings in this study show that topical azithromycin is an effective antibiotic with acceptable side effects and high degree of satisfaction in patients and it can be used for the treatment of mild forms of acne.
Layegh Pouran; Panah Mohammad Javad Yazdan; Dadkhah Seyed Masoud; Shakeri Mohammad Taqi; Vosough Elham Mohammadi
Volume 9, Issue 4 , 2006, , Pages 303-307
Abstract
Background and aim: Complications and resistance to pentavalent antimonial agents in cutaneous leishmaniasis, exhibit the need for effective alternative drugs. The aim of this study was to compare the efficacy of oral azithromycin with systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous ...
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Background and aim: Complications and resistance to pentavalent antimonial agents in cutaneous leishmaniasis, exhibit the need for effective alternative drugs. The aim of this study was to compare the efficacy of oral azithromycin with systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. Materials and Methods: Forty-seven patients with cutaneous leishmaniasis visited at the dermatology department of Qaem hospital were randomly divided to two groups. Twenty patients (with 29 lesions) were treated with oral azithromycin 500 mg/day for 5 successive days each month for 4 months and 27 patients (with 58 lesions) were treated with systemic Glucantime 60 mg/kg/day for 20 days. Azithromycin group patients were visited monthly and control group patients were visited in last day of treatment and 45 days later. Results:At the end of our study 10.3% of lesions in azithromycin group showed complete response, 27.6% lesions partial response and 62.1% no response. In Glucantime group 34.5% of lesions showed complete response, 13.8% partial response and 51.7% no response (P=0.036).Conclusion: In treatment of cutaneous leishmaniasis systemic Glucantime is superior to oral azithromycin. Differences between our result and previous studies may be due to difference between strains of Leishmanias and in vitro studies may be necessary to resolve this paradox. On the other hand, change in dosage and course of treatment with azithromycin may affect the efficacy of this agent.
