Rezvan Amiri; Saman Mohammadi; Saman Azizi; Abbas Pardakhty; Maryam Khalili; Mahin Aflatoonian
Abstract
Background: Conventional topical treatments for male-pattern alopecia (MPA) have limited penetration into hair follicles and unwanted side effects, resulting in low patient compliance. We aimed to evaluate the efficacy and safety of niosomal kopexil 1% lotion compared with niosomal minoxidil 2% lotion ...
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Background: Conventional topical treatments for male-pattern alopecia (MPA) have limited penetration into hair follicles and unwanted side effects, resulting in low patient compliance. We aimed to evaluate the efficacy and safety of niosomal kopexil 1% lotion compared with niosomal minoxidil 2% lotion in patients with MPA.Methods: We conducted a prospective, double-blind, randomized clinical trial at Afzalipour Hospital of Kerman University of Medical Sciences, Kerman, Iran. Thirty participants with MPA were randomized to apply 1 ml of niosomal minoxidil 2% lotion or niosomal kopexil 1% lotion twice a day for 24 weeks. We assessed the efficacy of treatments as the percentage of change in hair density in monthly sessions compared to the baseline using a dermatoscope; we also assessed patient satisfaction and side effects.Results: Thirty participants were enrolled, 29 of whom completed the study. The mean change in hair density was significantly higher with niosomal kopexil compared with niosomal minoxidil (23.2 ± 1.3 and 14.2 ± 0.2, respectively). The hair density increased by 57.6 ± 3.7% and 25.6 ± 4.2% in the kopexil and minoxidil groups, respectively (P < 0.001). Patients reported significantly greater satisfaction with niosomal kopexil than with niosomal minoxidil (P < 0.001). No side effects were reported in either group.Conclusion: Despite the lower concentration, niosomal kopexil revealed significantly higher efficacy of treatment and satisfaction of patients compared to niosomal minoxidil.
Azadeh Rakhshan; Afshin Moradi; Hedieh Peiroolia
Abstract
Background: Androgenic hair loss (AGA) and alopecia areata (AA) are common conditions which sometimes are histologically difficult to differentiate. This study was conducted to detect differentiating features of these two disorders with IHC analysis of T-cell subsets in the inflammatory ...
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Background: Androgenic hair loss (AGA) and alopecia areata (AA) are common conditions which sometimes are histologically difficult to differentiate. This study was conducted to detect differentiating features of these two disorders with IHC analysis of T-cell subsets in the inflammatory infiltrates of alopecia areata and androgenetic alopecia. Methods: This cross-sectional study was conducted at Shohadae-Tajrish Hospital in 2018. Twenty-eight cases of alopecia areata and 32 androgenic hair loss cases were evaluated. H&E and IHC staining for CD3, CD4, and CD8+ T-lymphocytes were performed. Lymphocytic densities were graded in a quintet grading system. The inflammation density in various areas of skin tissue was evaluated. Statistical analysis was performed using SPSS version 21. Results: Peribulbar lymphocytic infiltration was seen in 88.5% of AA patients and 12.5% of AGA patients (P = 0.000). Presence of melanin, pigmented casts, and lymphocytes in follicular stelawere in favor of AA diagnosis. CD3, CD4, and CD8+ T-cells in follicular stela, peri-bulbar, and subcutaneous regions were higher and denser in AA patients, while CD3 and CD4+ T-cells aroundsebaceous ducts were in favor of AGA diagnosis. Conclusion: Peribulbar lymphocytic infiltration is among the most important differentiating features of AA and AGA. Infiltration of T-cells in various regions of skin tissue has high diagnosticvalue. Histologic and immunohistochemical evaluation of skin tissues according to these factors can differentiate these two entities with high precision.
Zabolinejad Naghmeh; Hoseininejad Masoumeh; Jannatipour Maryam; Layegh Pouran
Volume 20, Issue 4 , 2017, , Pages 122-126
Abstract
Background: Hair loss is a major cause of dermatology visits resulting in considerable anxiety and distress for patients. The objective of the current research was to investigate the association among various diagnostic methods related to non-scarring hair loss in women. Methods: After obtaining the ...
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Background: Hair loss is a major cause of dermatology visits resulting in considerable anxiety and distress for patients. The objective of the current research was to investigate the association among various diagnostic methods related to non-scarring hair loss in women. Methods: After obtaining the complete history, clinical examination was carried out on women suffering from diffuse nonscaring alopecia. Laboratory tests and histo-pathologic study were conducted for each patient, and ultimately, data were analyzed by SPSS version 16. Result: Forty-one women were enrolled with the average age of 28.1±8.4 years (16-48). Mean duration of hair loss was 6.2 years (2 months-20 years). The most prevalent type of hair loss was androgenetic alopecia. The sensitivity and specificity with which the clinical examination was done to detect this common ilk of hair loss was 94% and 25%, respectively. No acceptable correlation existed between laboratory test results (such as testosterone, DHEAS, ferritin and TSH) and clinical diagnosis. Data were further assessed through the use of IBM SPSS software version 22 using fisher exact test and Kappa coefficient. The significance level was set at p<0.05. Conclusion: Clinical examination is an accurate approach to diagnosing certain types of non-scarring hair loss in women, eliminating the necessity to perform various endocrinology and laboratory tests; however, it is only through histopathologic studies that an exact diagnosis is specified.
Mohammad Ebrahimzadeh; Ali Pedarzadeh; Farideh Dehghani; Mohammad Moslemzadeh
Volume 19, Issue 1 , 2016, , Pages 6-10
Abstract
Background: Worldwide, coronary heart disease is the most important cause of mortality and morbidity. Although numerous studies have documented the relationship between male pattern baldness and cardiovascular disease (CVD), few studies focused on this association in women. This study intended to evaluate ...
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Background: Worldwide, coronary heart disease is the most important cause of mortality and morbidity. Although numerous studies have documented the relationship between male pattern baldness and cardiovascular disease (CVD), few studies focused on this association in women. This study intended to evaluate the relationship between coronary artery disease and androgenetic alopecia (AGA) in both men and women.Methods: This case-control study included 200 people, 100 (50 men and 50 women) with coronary heart disease (CHD) and 100 healthy control subjects (50 men and 50 women). Both groups were assessed for grading the severity of their baldness. The collected data were analyzed by the chi-square test.Results: A total of 74% of participants in this group had hair loss severity of grades IV-VIII, however in the control group, 50% had remarkable hair loss. There was a significant association between coronary artery disease and hair loss grade IV onward in men (P=0.038) but this relationship was not observed in women.Conclusion: Male patients with AGA are at greater risk for developing CVD.
Tehranchinia Zohreh; Namazi Nastaran; Sarah Ershadi; Laya Rahbar Nikoukar; Gity Taheri
Volume 18, Issue 2 , 2015, , Pages 41-44
Abstract
Background: Androgenetic alopecia (AGA) is a non-scarring alopecia which consists of miniaturization of the terminal hair under the influence of androgens. Some scholars have reported an association between AGA and coronary artery disease (CAD), probably due to alterations in CAD risk factors. However, ...
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Background: Androgenetic alopecia (AGA) is a non-scarring alopecia which consists of miniaturization of the terminal hair under the influence of androgens. Some scholars have reported an association between AGA and coronary artery disease (CAD), probably due to alterations in CAD risk factors. However, this association is not supported by other studies, thus rendering the subject open to discussion.Methods: A total of 100 women were enrolled in this study: 50 diagnosed with AGA based on physical examination and 50 agematched controls. BMI as well as serum total cholesterol, highdensity lipoprotein (HDL-C), low-density lipoprotein (LDL-C), and triglyceride were measured.Results: The mean BMI was 25.3±3.5 kg/m2 in the AGA group and 24.2±3.4 kg/m2 in the control group (P=0.11). The mean level of triglyceride, total cholesterol, HDL-C, and LDL-C in the AGA group was 141.7±55.4 mg/dl, 194.9±35.8 mg/dl, 41.1±12.3 mg/ dl, and 129.7±32.6 mg/dl, respectively. These figures showed no significant difference in the control group (P=0.10)Conclusion: It seems that a diagnosis of AGA in female patients is not linked to increased serum lipids.
S Nassiri; S Taghavian Pour; A Sadiqha
Volume 8, Issue 4 , 2005, , Pages 266-271
Abstract
Background an objective: Several studies have indicated that vertex type androgenetic alopecia have a higher-than-normal risk for coronary heart disease but few studies focused on lipid profiles which are important in the pathogenesis of coronary heart disease. This study was designed to investigate ...
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Background an objective: Several studies have indicated that vertex type androgenetic alopecia have a higher-than-normal risk for coronary heart disease but few studies focused on lipid profiles which are important in the pathogenesis of coronary heart disease. This study was designed to investigate the relation between vertex type androgenetic alopecia (Grade III and higher according to Hamilton-Norwood) and hyperlipidemia.Materials and Methods: In this case-control study, lipid parameters (Total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, total cholesterol/HDL cholesterol ratio) of 50 men with vertex type androgenetic alopecia (Study group) were compared with 50 men with normal hair status (Control group). Study group matched according to the age, BMI and habit of smoking with control group.Results: Study group had a higher triglyceride and lower HDL cholesterol levels than control group. Total cholesterol/HDL cholesterol ratio was significantly higher in study group (P<0.05).Conclusion: Vertex type androgenetic alopecia could be a clinical marker of hyperlipidemia and dermatologists should investigate lipid profile in these patients.