Armaghan Kazeminejad; Lotfollah Davoodi; Zohreh Hajheydari; Erfan Ghadirzadeh; Amirmasoud Taheri; Mohammad Ahmadi; Alireza Mozdastan
Abstract
Background and Method: Psoriasis is one of the most common skin diseases. For the first time in Iran, we conducted a case-control study to evaluate bone mineral density in patients with psoriasis vulgaris in comparison with a healthy control group (20 individuals in each group). Our study sample included ...
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Background and Method: Psoriasis is one of the most common skin diseases. For the first time in Iran, we conducted a case-control study to evaluate bone mineral density in patients with psoriasis vulgaris in comparison with a healthy control group (20 individuals in each group). Our study sample included patients referred to the dermatology clinic of Razi Hospital in Ghaemshahr, Iran, between May and October 2019. Densitometry was performed by the DEXA method on the 2nd to 4th lumbar vertebrae and hip bone. Patients’ demographic information and Psoriasis Area Severity Index (PASI) scores were recorded and analyzed using SPSS version 22.Results: The mean T-score in the case and control groups were -0.47 ± 1.04 and -0.19 ± 0.45, respectively (P = 0.274). The mean T-score had a significant inverse correlation with an age of 40 years or above (r = -0.873 and P < 0.001), disease duration of more than five years (r = -0.599, P = 0.05), and PASI score (r = -0.523, P = 0.001), but had a positive correlation with sunlight exposure (r = 0.581, P < 0.001).Conclusion: Considering the decrease in bone density in patients with psoriasis and its relationship with the disease severity and duration and the effectiveness of sunlight in increasing bone density, preventive treatment should be provided for all patients to increase bone density and prevent osteoporosis.
F Ghalamkar Pour; H Morravej Farshi; S Zolghadr
Volume 8, Issue 6 , 2006, , Pages 448-456
Abstract
Background and aim: Side effects of long-term systemic isotretinion use with high accumulative doses on skeletal system have been known, but there are few studies about the effects of short term isotretinoin therapy for acne patients. This study was aimed to recognize the effects of systemic isotretinion ...
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Background and aim: Side effects of long-term systemic isotretinion use with high accumulative doses on skeletal system have been known, but there are few studies about the effects of short term isotretinoin therapy for acne patients. This study was aimed to recognize the effects of systemic isotretinion on calcium homeostasis and bone density in acne patients referring to clinics affiliated to the Skin Research Center of Shahid Beheshti University of Medical Sciences.Materials and Methods: In this before and after clinical trial, 20 patients with severe acne vulgaris in whom systemic treatment with isotretinoin was indicated were assessed. They included 13 female and 7 male patients with a mean age of 24.3±4.7 years. Serum levels of calcium, phosphorus and alkaline phosphatase as well as lumbar and hip bone mineral density (BMD) of the patients were evaluted before and after treatment with 120 mg/kg total dose of isotretinion. Results were analysed using Wilcoxon signed ranked test before and after treatment and P values less than 0.05 were considered statistically significant.Results: The mean levels of serum calcium and alkaline phosphatase were decreased after treatment course while the mean level of serum phosphorus was increased in comparison to their mean levels before the treatment but the changes were statistically non-significant. BMD of neck and total femur showed no significant difference, but trivial increase (0.0151 gr/cm2) was detected in lumbar BMD after treatment (P<0.05).Conclusion: Considering no significant change in neck and total femur BMD and trivial and clinically unimportant increase in lumbar BMD (L<sub>2</sub>-L<sub>4</sub>), it seems that 120 mg/kg total dose of isotretinion that is used for acne has no significant effect on skeletal system.
