Saman Ahmad Nasrollahi; Zaynab Variji; Zahra Ghasemi; Somayeh Yadangi; Aniseh Samadi; Alireza Firooz
Abstract
Background: Cellulite is a cosmetic problem, especially in women. We compared the safety and efficacy of a herbal anti-cellulite lotion with a placebo in a randomized, double-blind, right-left comparison clinical trial.Methods: Ten healthy women (22-58 years) with cellulite (grades 2-4) participated ...
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Background: Cellulite is a cosmetic problem, especially in women. We compared the safety and efficacy of a herbal anti-cellulite lotion with a placebo in a randomized, double-blind, right-left comparison clinical trial.Methods: Ten healthy women (22-58 years) with cellulite (grades 2-4) participated in this study. The anti-cellulite lotion and placebo were applied twice daily on the thighs and buttocks for two months. Treated areas were photographed, and the thigh circumference, subcutaneous fat thickness, and dermal echo density were assessed and compared before and after the treatment. The satisfaction of the participants was also assessed.Results: A comparable improvement in cellulite grade was detected by a blinded dermatologist on both treatment sides. Cellulite improved much in one participant, improved in six, and did not change in three participants. The dermis thickness increased compared with placebo after two months (P = 0.046). A significant reduction was observed in subcutaneous fat thickness on the treated side (P = 0.03). However, the decrease was not significant on the placebo site. There was an increase in the echo density of the dermis in the treatment site, though it was not statistically significant. Both products were well tolerated, and none of the participants experienced skin burning or itching.Conclusion: The studied anti-cellulite lotion reduced the thickness of subcutaneous fat and increased the dermis thickness without serious adverse effects.
Nasrollahi Saman Ahmad; Hasanzadeh Hournaz; Ajami Marjan; Ameri Setareh; Variji Zeinab; Komeili Ali; Firooz Alireza
Volume 18, Issue 4 , 2015, , Pages 145-150
Abstract
Background: Cellulite is a common disease whose exact mechanism is unknown. This study was aimed to assess the safety and efficacy of an anti-cellulite preparation compared with placebo in a randomized double-blind, right-left comparison clinical trial.Methods: Twelve healthy women aged 22 to 58 years ...
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Background: Cellulite is a common disease whose exact mechanism is unknown. This study was aimed to assess the safety and efficacy of an anti-cellulite preparation compared with placebo in a randomized double-blind, right-left comparison clinical trial.Methods: Twelve healthy women aged 22 to 58 years with mild to moderate cellulite on their thighs and buttocks participated in this trial. The anti-cellulite preparation (Three O cream, Pouya Varzan Tejarat Sepahan Co., Iran) and an identical placebo were randomly applied on the right or left thigh and buttock twice a day for 2 months. The mentioned areas were photographed and the circumference, subcutaneous fat thickness, and dermis density and thickness were measured before and after treatment. A satisfaction questionnaire was completed by all volunteers to assess their satisfaction with the efficacy of treatment on each side.Results: There was no significant difference between active and placebo treatment sides in any of measurements. About 90% of participants had an overall satisfaction of 5 and more than 5 based on a 0 to 10 visual analogue scale on the side of anti-cellulite cream. This score was similar on the sides treated with placebo and the active product.Conclusion: Although Three O cream provided more satisfaction in volunteers than placebo, the objective measurements did not show any difference between them.
Shahla Babae Nejad; Neda Yousefi; Hamideh Herizchi; Effat Khodaeiani; Mohamad Sadeghi; Mohamad Goldust
Volume 13, Issue 3 , 2010, , Pages 87-90
Abstract
Background: Scabies is one of the health care problems in our community and is an endemic problem at any time. Its current therapy in Iran is lindane 1% lotion, which is deleted from market in many countries because of multiple side effects and better alternatives. The aim of this study was to evaluate ...
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Background: Scabies is one of the health care problems in our community and is an endemic problem at any time. Its current therapy in Iran is lindane 1% lotion, which is deleted from market in many countries because of multiple side effects and better alternatives. The aim of this study was to evaluate the efficacy and side effects of lindane in patients with scabies and to replace lindane with other safer and more effective scabicides in case of high treatment failure rates.Method: 100 patients with clinical diagnosis of scabies were treated with two lindane 1% lotions with an interval of one week. The patients were examined two and four weeks after the initial treatment in order to evaluate clinical cure. Data was analyzed with SPSS-13.Results: The mean age of the patients was 33.74 years. Of them, 52% were male and 48% were female, 60% were married and close contact was found in 100% of the patients as the route of transmission of the disease. Symptoms reduced in 75% of the patients after two times of applying lindane. Itching decreased 3 days after applying Lindane and disappeared completely on the seventh day. Fifty four percent were free of disease 28 days after treatment.Conclusion: In this study, the failure rate of treatment with lindane was relatively high; therefore, it seems necessary to think of other alternative scabicides (such as permethrin 5% cream) for the treatment of scabies. Furthermore, with accurate usage, lindane is a safe topical modality and we found no adverse effects related to lindane.
Esmaili Nafiseh; Hallaji Zahra; Ehsani Amirhoushang; Tork Ali Naser; Robati RezaMahmood; Toosi Siavash; Zahrian Fatemeh; Maarefat Afsaneh
Volume 10, Issue 2 , 2007, , Pages 100-104
Abstract
Background and aim: Psoriasis is one of the most common inflammatory skin disorders with a genetic background. Several treatment modalities have been used, including systemic and bath PUVA. The aim of this study was to evaluate the efficacy of systemic and bath PUVA in the treatment of psoriasis in Razi ...
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Background and aim: Psoriasis is one of the most common inflammatory skin disorders with a genetic background. Several treatment modalities have been used, including systemic and bath PUVA. The aim of this study was to evaluate the efficacy of systemic and bath PUVA in the treatment of psoriasis in Razi Hospital.Materials and methods: This retrospective database study was done in Razi Hospital and the records of 390 psoriatic patients referred to phototherapy unit in 1999-2003 were studied. One hundred and forty nine patients were treated with systemic and 238 patients with bath PUVA.Results: The most common form of psoriasis was the plaque type and the majority of patients were male. Complete remission of disease was achieved in 20.1% of systemic PUVA and 17.2% of bath PUVA patients, usually after 20-29 sessions of phototherapy. The mean cumulative UVA dose for complete remission was 233.46 and 108.79 J/cm2 in systemic and bath PUVA groups, respectively. Relapse occurred in 33.3% and 17.07% of patients achieving complete remission in systemic and bath PUVA groups, respectively. Erythema was the most common side effect in both groups.Conclusion: Both systemic and bath PUVA are efficacious in the treatment of psoriasis. The total UVA dose needed for complete clearance was higher in systemic PUVA and relapse occurred more frequently in this group.
Z Hallaji; Sh Shams Davatchi; M Vali Khani; N Ghandi; M Kar Bakhsh Davari; M Hedayati; AR Firooz
Volume 9, Issue 3 , 2006, , Pages 204-210
Abstract
Background and aim: Azathioprine is the most widely used immunosuppressive agent as an adjunct to corticosteroids in the treatment of pemphigus vulgaris (PV). Thiopurine methyl transferase (TPMT) is a key enzyme in azathioprine metabolism and a genetic polymorphism controls its activity in human tissue. ...
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Background and aim: Azathioprine is the most widely used immunosuppressive agent as an adjunct to corticosteroids in the treatment of pemphigus vulgaris (PV). Thiopurine methyl transferase (TPMT) is a key enzyme in azathioprine metabolism and a genetic polymorphism controls its activity in human tissue. TPMT activity can provide a rational basis to determine suitable dose of azathioprine, theoretically. The aim of this study was to evaluate the clinical relevancy of this hypothesis in PV patients.Materials and Methods: In this cross sectional study in Razi Hospital, the activity of TPMT in the red blood cells of 52 PV patients who received azathioprine for at least 12 months and 29 PV patients who did not receive this drug was measured and correlated to the clinical response and side effects observed.Results:The mean of TPMT activity was not significantly different in patients with unfavourable response, comparing to patients with favorable response to azathioprine (P=0.087). No relationship was observed between total dose of corticosteroid and TPMT activity (r=0.089, P=0.583). There was no difference between the mean of TPMT activity in patients receiving azathioprine and those not receiving this drug (P=0.36).Conclusion: A direct relationship was not observed between TPMT activity and clinical efficacy and side effects in PV patients under treatment with azathioprine. Larger prospective studies in more homogenous patients are needed to evaluate the clinical relevance of TPMT polymorphism and to determine accurate azathioprine dosing guidelines based on TPMT activity.