Azadeh Mohebbi; Rezvan Amiri; Nasim Nejadsajadi; Maryam Khalili; Saman Mohammadi; Abnoos Mokhtari; Mahin Aflatoonian; Zahra Rahnama
Abstract
Background: The association of cherry angioma with metabolic syndrome and fatty liver has been proposed in a few studies. This study evaluated the prevalence of cherry angiomas in patients with type II diabetes mellitus compared with healthy adults.Methods: This cross-sectional study was conducted on ...
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Background: The association of cherry angioma with metabolic syndrome and fatty liver has been proposed in a few studies. This study evaluated the prevalence of cherry angiomas in patients with type II diabetes mellitus compared with healthy adults.Methods: This cross-sectional study was conducted on 100 patients with type II diabetes mellitus and 100 age and sex-matched healthy adults. Demographic features of the participants and the location and number of the lesions were recorded. Data were analyzed by SPSS 16. Mean ± standard deviation and frequency were used for quantitative analysis. The chi-squared test and independent t-test were utilized to evaluate the association of qualitative and quantitative data with the number of cherry angiomas, respectively.Results: Cherry angiomas were more prevalent in the diabetes group (47%) than in controls (30%) (P = 0.013). Lesions in diabetic patients were more prevalent in females than males (P = 0.042). Furthermore, the number of lesions in the diabetes group significantly increased parallel to aging (P = 0.004).Conclusion: In the present study, significantly more cherry angiomas were observed in patients with type II diabetes mellitus than in healthy controls. Furthermore, the number of lesions was higher in females and elderly subjects in the diabetes group.
Arunima Dhabal; Jayanta Kumar Barua; Kingshuk Chatterjee; Ananya Chandra; Sumana Khan; Manab Kumar Ghosh; Saswati Halder
Abstract
Background: Lichen planus (LP) is a chronic inflammatorydisorder involving the skin, mucosa, hair, and nails. Previousreports have shown a possible association between LP andmetabolic derangement, leading to increased cardiovascular riskamong these patients. Our study aimed to assess the prevalenceof ...
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Background: Lichen planus (LP) is a chronic inflammatorydisorder involving the skin, mucosa, hair, and nails. Previousreports have shown a possible association between LP andmetabolic derangement, leading to increased cardiovascular riskamong these patients. Our study aimed to assess the prevalenceof metabolic syndrome (MetS) and its components in LP patientsand to study their relationship with mucosal involvement in LP.Methods: We conducted a cross-sectional observational study of123 LP patients. Demographic and clinical data were obtained,and evaluation was done for the presence of abdominal obesity,hypertension, hyperglycemia, and dyslipidemia. MetS wasdiagnosed according to the modified National CholesterolEducation Program: Adult Treatment Panel III (NCEP-ATP III)criteria for the South Asian population. Data analysis was doneusing appropriate statistical methods.Results: The prevalence of MetS in LP patients was 31%. The meanage of LP patients having MetS was considerably higher thanthose without MetS (44.8 ± 13.6 vs. 33.3 ± 15.9 years; P = 0.0002).Although statistically insignificant, female patients and patients withmucosal involvement showed a higher prevalence of MetS. Centralobesity, hypertension, hyperglycemia, and hypertriglyceridemiawere more prevalent in mucosal LP patients than in those withoutmucosal lesions, with hyperglycemia having a significantly higherprevalence in mucosal LP (41% vs. 18%; P = 0.015).Conclusion: Incre ased age, female gender, and mucosalinvolvement are important predictors of concurrent metabolicderangement in LP patients. Thus, these patients should bescreened for the presence of MetS and its components.
Prodip Sarkar; Karunamoy Chakraborti; Sudeshna Mondal; Loknath Ghoshal; Debabrata Bandyopadhyay
Abstract
Background: Androgenetic alopecia is defined as patterned hair loss caused by androgens in genetically susceptible individuals. Metabolic syndrome is a cluster of interrelated risk factors that increase the risk of coronary artery disease. Androgenetic alopecia is associated with metabolic syndrome components ...
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Background: Androgenetic alopecia is defined as patterned hair loss caused by androgens in genetically susceptible individuals. Metabolic syndrome is a cluster of interrelated risk factors that increase the risk of coronary artery disease. Androgenetic alopecia is associated with metabolic syndrome components including insulin resistance, dyslipidemia, and obesity. This study aimed to compare the prevalence of metabolic syndrome in androgenetic alopecia patients with controls.Methods: The study groups consisted of 50 androgenetic alopecia patients and 50 controls who agreed to participate. Following recruitment into the study, history taking, clinical examination, and laboratory investigations were carried out, and details of each individual were recorded into a pre-structured case record sheet.Results: The groups were not statistically different in terms of age or sex distribution, height and weight, glucose levels, thyroid hormone level, blood counts, and lipid levels. We found that 26% of patients in the case group and 6% in the control group satisfied the definition of metabolic syndrome; this difference was significant (P = 0.007). We observed a statistically significant difference in LDL and HDL levels between the cases and controls (P = 0.0027 and 0.0091, respectively).Conclusion: Patients with androgenetic alopecia have an increased likelihood of having metabolic syndrome and must be routinely screened for hypertension, diabetes mellitus, and dyslipidemia. They should be made conscious of the more serious implications of the apparently cosmetic disorder.
Saman Mohammadi; Nasim Askari; Maryam Khalili; Rezvan Amiri; Mahin Aflatoonian
Abstract
Background: The increased prevalence of metabolic syndrome has been established in chronic inflammatory skin diseases. Patients with metabolic syndrome have a higher mortality rate due to cardiovascular disease and malignancy. In this study, the prevalence of metabolic syndrome was evaluated in lichen ...
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Background: The increased prevalence of metabolic syndrome has been established in chronic inflammatory skin diseases. Patients with metabolic syndrome have a higher mortality rate due to cardiovascular disease and malignancy. In this study, the prevalence of metabolic syndrome was evaluated in lichen planus patients compared with a control group in Kerman, southeast Iran.Methods: This was a cross-sectional study on 90 patients with lichen planus and 90 healthy participants from the Dermatology Clinic of Afzalipour Hospital, Kerman, Iran. Demographic features of the patients and clinical features of the lesions were recorded. Then, parameters of metabolic syndrome were evaluated in both groups. The independent t-test and chi-squared test were used to compare quantitative and qualitative variables, respectively.Results: There was no significant difference in demographic features of the participants between the two groups. Metabolic syndrome was significantly more prevalent in the lichen planus group (62.6%) than in the control group (14.4%) (P = 0.001). Metabolic syndrome parameter values (except waist circumference) were significantly higher in the lichen planus group than in the control group. Lichen planus patients with metabolic syndrome had a significantly higher percentage of mucosal involvement (66.1%) than lichen planus patients without metabolic syndrome (44.1%). Lichen planus patients with metabolic syndrome were significantly older than those without metabolic syndrome.Conclusions: This study observed a higher prevalence of metabolic syndrome in lichen planus patients relative to controls. Furthermore, lichen planus patients with metabolic syndrome had significantly higher age, mucosal involvement, and body mass index than lichen planus patients without metabolic syndrome.
Maryam Nasimi; vahide Lajevardi; Hamidreza Mahmoudi; Fatemeh Arbab; Safoura Shakoei
Abstract
Background: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology. There is conflicting data on the link between LP and metabolic syndrome. This study evaluated the association of chronic subtypes of LP, namely oral lichen planus and lichen planopilaris (LPP), with metabolic syndrome.Methods: ...
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Background: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology. There is conflicting data on the link between LP and metabolic syndrome. This study evaluated the association of chronic subtypes of LP, namely oral lichen planus and lichen planopilaris (LPP), with metabolic syndrome.Methods: In this cross-sectional study, 66 patients with oral and follicular LP were evaluated for metabolic syndrome based on the US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria and were compared against 66 healthy controls. Waist circumference, body mass index (BMI), systolic and diastolic blood pressure, fasting blood sugar (FBS), and lipid profile were measured for each individual.Results: There was no significant difference in the prevalence of metabolic syndrome (13 [19.7%] vs. 8 [12.1%]; P = 0.23) and dyslipidemia (51 [77.3%] vs. 49 [74.2%]; P = 0.68) between the study groups. These findings remained statistically insignificant in both genders. The waist circumference (P = 0.008) and diastolic blood pressure (DBP) (P = 0.02) were significantly higher in the LP group than the healthy individuals. Our data showed that each unit increment in waist circumference and DBP leads to a 4.1% (P = 0.02) and 4.7% (P = 0.03) increase in the chance of LP,respectively.Conclusion: Patients with oral LP and LPP do not have a higher prevalence of metabolic syndrome or dyslipidemia than healthy individuals. However, they are more vulnerable to central obesity and high diastolic pressure, for which they should be routinely screened.
Ghazal Shariatpanahi; Rezvan Hashemi; Mahsa Asadabadi; Nava Shirzadi; Nazgol Sadat Haddadi; Safoura Shakoei
Abstract
Background: Acne is a common chronic inflammatory skin disease predominantly occurring during adolescence; this condition adversely affects a person’s self-esteem and can be associated with metabolic disorders. This study aimed to investigate the prevalence of metabolic syndrome and its components ...
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Background: Acne is a common chronic inflammatory skin disease predominantly occurring during adolescence; this condition adversely affects a person’s self-esteem and can be associated with metabolic disorders. This study aimed to investigate the prevalence of metabolic syndrome and its components in adolescent girls with acne compared to a control group. Materials and Methods: In this cross-sectional study,105 adolescent girls aged 12-18 years were assigned to either the acne (case; n=55) or control group (n=50). The case group was selected from the Dermatology Department of a general hospital in Tehran, Iran, between January and August 2017. Acne lesions were confirmed and graded by a dermatologist. Clinical and biochemical parameters were evaluated for all participants. Results: The prevalence of metabolic syndrome in patients with and without acne was 18.2% and 14%, respectively. As a result, metabolic syndrome was not correlated with acne in adolescent girls (P=0.561). In addition, the mean body mass index (P=0.89), waist circumference (P=0.62), mean systolic and diastolic blood pressures (P=0.57 and 0.62, respectively), fasting blood sugar (P=0.59), total cholesterol, and low-density lipoprotein cholesterol levels were comparable between the studied groups (P>0.05). Moreover, triglyceride levels were significantly lower in the acne group (P=0.028), whereas this group featured a higher level of high-density lipoprotein cholesterol (P=0.02). However, the logistic regression results showed that none of the measured lipids were associated with acne. Conclusion: The findings indicated that metabolic syndrome and its components (representing metabolic imbalance) were not correlated with acne in adolescent girls.
Ahmad Reza Taheri; Mozhgan Afkhamizadeh; Sara Sabourirad; Omid Hassani; Somaye Ghanizadeh
Abstract
Background: Androgenetic alopecia (AGA) is the most prevailing type of progressive hair loss. Thus far, some previous studies have investigated the correlation between AGA and metabolicsyndrome (MetS). However, due to the inconsistency of their results, our study aims at evaluating the ...
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Background: Androgenetic alopecia (AGA) is the most prevailing type of progressive hair loss. Thus far, some previous studies have investigated the correlation between AGA and metabolicsyndrome (MetS). However, due to the inconsistency of their results, our study aims at evaluating the association between AGA and MetS.Methods: Fifty two male patients with grade III-V AGA, based on Ebling’s scale, and 50 control subjects were enrolled in the present study. All participants were evaluated for the presenceof Mets based on the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III).Results: The prevalence of MetS was 51.3% in AGA group and 17.8% in control group (P=0.003). Among MetS parameters, Systolic blood pressure (P=0.003) and waist circumference (P<0.001)were statistically significant in AGA patients compared to the control group.Conclusion: Our study demonstrated that the association between AGA and MetS is of great importance. Therefore, early detection can be beneficial for early intervention to lower the incidence of MetS and further complications.
