Azadeh Mohebbi; Rezvan Amiri; Nasim Nejadsajadi; Maryam Khalili; Saman Mohammadi; Abnoos Mokhtari; Mahin Aflatoonian; Zahra Rahnama
Abstract
Background: The association of cherry angioma with metabolic syndrome and fatty liver has been proposed in a few studies. This study evaluated the prevalence of cherry angiomas in patients with type II diabetes mellitus compared with healthy adults.Methods: This cross-sectional study was conducted on ...
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Background: The association of cherry angioma with metabolic syndrome and fatty liver has been proposed in a few studies. This study evaluated the prevalence of cherry angiomas in patients with type II diabetes mellitus compared with healthy adults.Methods: This cross-sectional study was conducted on 100 patients with type II diabetes mellitus and 100 age and sex-matched healthy adults. Demographic features of the participants and the location and number of the lesions were recorded. Data were analyzed by SPSS 16. Mean ± standard deviation and frequency were used for quantitative analysis. The chi-squared test and independent t-test were utilized to evaluate the association of qualitative and quantitative data with the number of cherry angiomas, respectively.Results: Cherry angiomas were more prevalent in the diabetes group (47%) than in controls (30%) (P = 0.013). Lesions in diabetic patients were more prevalent in females than males (P = 0.042). Furthermore, the number of lesions in the diabetes group significantly increased parallel to aging (P = 0.004).Conclusion: In the present study, significantly more cherry angiomas were observed in patients with type II diabetes mellitus than in healthy controls. Furthermore, the number of lesions was higher in females and elderly subjects in the diabetes group.
Bhola Nath; Shiv Dutt Gupta; Ranjeeta Kumari
Abstract
Background: Diabetes mellitus is a non-communicable disease that affects all the body’s organ systems, including the dermatologic system. Skin lesions can cause discomfort, harm one’s quality of life (QOL), and increase treatment costs. The objective of conducting this study was to compare ...
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Background: Diabetes mellitus is a non-communicable disease that affects all the body’s organ systems, including the dermatologic system. Skin lesions can cause discomfort, harm one’s quality of life (QOL), and increase treatment costs. The objective of conducting this study was to compare the proportion of dermatologic comorbidities, the direct cost of treatment, and the QOL between cases and controls.Methods: The study was conducted in a medical college hospital in the hilly region of Uttarakhand using a case-control design. Cases were recruited from the Outpatient Department (OPD) and controls from the hospital. Comparisons were made for the presence of skin diseases between 195 patients with diabetes andan equal number of age and gender-matched non-diabetics. The independent t-test was used to compare QOL and treatment cost between the two groups.Results: The risk of skin diseases was 5.3 times higher in cases than in controls. The proportion of skin diseases in cases was 36.4% versus 9.7% in controls. Limitations: There is a probability that the QOL scores could be lower and the treatment cost higher than that observed.Conclusion: The proportion of skin disorders and the mean direct cost of treatment was reported to be significantly higher among cases.
Kang Nien How; Ikmal Hisyam Bakrin; Norashikin Shamsudin
Abstract
Granuloma annulare (GA) is an idiopathic benign skin disease, characterized by annular dermal plaques or papules. Much is still unknown concerning its aetiology, association, and pathogenesis.We report two patients with generalized GA (GGA), with different age of presentation, co-morbidities, ...
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Granuloma annulare (GA) is an idiopathic benign skin disease, characterized by annular dermal plaques or papules. Much is still unknown concerning its aetiology, association, and pathogenesis.We report two patients with generalized GA (GGA), with different age of presentation, co-morbidities, and disease morphology. Herein, we report two patients with GGA with different clinical features, disease morphologies, and histology patterns. We also illustrate the treatment used in our patients and the outcome. GA is a self-limiting disease and can regress spontaneously. GGA tends to be more persistent and usually requires treatment for symptomatic or cosmetic reasons. Expert consensus on treatments recommends topical corticosteroid, psoralen and ultraviolet A (PUVA), and antimalarial drugs.
Shahzad Shahid; Taheri Ahmad Reza; Javidi Zari; Dorgalaleh Akbar; Tabibian Shadi; Bamedi Taregh; Dorgalaleh Saeed; Moemeni Mohammad
Volume 17, Issue 1 , 2014, , Pages 22-26
Abstract
Background: Vitiligo is a common acquired disorder of the skin. The disease is characterized by depigmented macules and patches on the skin. Autoimmunity has a crucial role in the pathogenesis of the vitiligo. Vitiligo is frequently associated with different autoimmune diseases such as thyroid abnormalities ...
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Background: Vitiligo is a common acquired disorder of the skin. The disease is characterized by depigmented macules and patches on the skin. Autoimmunity has a crucial role in the pathogenesis of the vitiligo. Vitiligo is frequently associated with different autoimmune diseases such as thyroid abnormalities and diabetes. This study aimed to evaluate the association between vitiligo and diabetes mellitus.Method: This case-control study was conducted on 70 patients with established vitiligo disorder and 70 non vitiligo individuals as the control group. In the case group, we performed two tests, fasting blood sugar (FBS) and oral glucose oral tolerance test (OGTT), while only FBS was checked in the control group.Result: The results of our study showed that out of 70 people in the case group, 18 (25.71%) had impaired FBS while only 4 (5.7%) had impaired GTT3. Statistical analysis showed p-value=0.015 which indicated a significant difference in impaired FBS between case and control groups. We had half and 1 hour GTT data (GTT1 and GTT2) and all patients with impaired GTT1 (4 individuals) and GTT2 (5 individuals) were females with a significant difference (P-value = 0.021 and 0.017, respectively).Conclusion: Periodical laboratory investigation for diabetes mellitus in vitiligo patients, particularly in females, seems to be necessary.
Farhad Malekzad; Reza Robati; Hamidreza Abaei; Somayeh Hejazi; Azin Ayatollahi; Shima Younespour
Volume 14, Issue 4 , 2011, , Pages 136-139
Abstract
Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance.Methods: This single-centre, ...
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Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance.Methods: This single-centre, case- control study was performed between 2008 and 2010 to evaluate the metabolic state of thirty chronic plaque type psoriatic patients in comparison with the control group. The criteria of insulin resistance (Body Mass Index (BMI), Systolic Blood Pressure, Fasting Plasma Glucose, Oral Glucose Tolerance Test (OGTT), Serum Insulin and Lipid Profile) were assessed for each participant.Results: Thirty psoriatic patients with a mean disease duration of 3.94 + 2.96 years and 30 healthy controls were recruited for the study. Only one patient in each group filled the criteria of insulin resistance, and there was no significant difference between the two groups. The mean Fasting Plasma Glucose (FPG), Triglyceride (TG) and Systolic Blood Pressure (SBP) levels were significantly higher in psoriasis patients as compared to the controls (p=0.044, p=0.014 and p=0.001, respectively). In contrast, no statistically significant differences were observed in mean BMI, OGTT, insulin and HDL levels between the two groups.Conclusion: Despite the absence of any significant association between insulin resistance and psoriasis, it could be concluded that psoriasis may be an independent risk factor for diseases such as Ischemic Heart Disease (IHD) and Diabetes Mellitus (DM), hypertension and obesity.
Esfandiarpour Iraj
Volume 12, Issue 3 , 2009, , Pages 93-95
Abstract
Necrobiosis lipoidica diabeticorum (NLD) is a rare chronic and granulomatous skin disorder that affects 0.3% of diabetic patients. Although the etiology and pathogenesis of NLD is still contraversial, it is thought that microangipathy has an important role. The legs are the most common site for NLD, ...
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Necrobiosis lipoidica diabeticorum (NLD) is a rare chronic and granulomatous skin disorder that affects 0.3% of diabetic patients. Although the etiology and pathogenesis of NLD is still contraversial, it is thought that microangipathy has an important role. The legs are the most common site for NLD, but involvement of other areas such as the abdomen, upper extremities and scalp have been reported. We present a case of scalp and leg NLD which was diagnosed on the clinical and histopathological basis.
Fatma Hussain; Muhammad Arif Mann; Munir Ahmed
Volume 12, Issue 2 , 2009, , Pages 47-51
Abstract
Background: Endocrine disorders occasionally manifest themselves by their associated or induced cutaneous abnormalities. Skin is a frequently overlooked source of pathology. Several cutaneous abnormalities are more prevalent in diabetes mellitus. The purpose of the study was to evaluate the frequency ...
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Background: Endocrine disorders occasionally manifest themselves by their associated or induced cutaneous abnormalities. Skin is a frequently overlooked source of pathology. Several cutaneous abnormalities are more prevalent in diabetes mellitus. The purpose of the study was to evaluate the frequency of skin infections among type 2 diabetic patients and associated risk factors in Faisalabad, PakistanMethods: Type 2 diabetic patients (disease duration >1 year) and healthy volunteers were recruited and skin infections were assessed.Results: Diabetes related skin infections were detected in 43% of type 2 diabetic patients and in 22.5% of the control subjects. Onychomychosis, candida vaginitis and herpes simplex were identified in 9.2 % of the diabetic patients compared to 2.5% of the control subjects. Skin infections had an insignificant association with sex, mean age, age at diabetes diagnosis, diabetes duration, secondary complications of diabetes, blood glucose and cumulative haemoglobin.Conclusion: A broad spectrum of cutaneous disorders was seen in type 2 patients. While the pathogenesis of the most of the skin lesions remains ambiguous, additional studies should be performed to determine whether skin lesions could be used for predicting imminent diabetic complications.
F Pezeshk Pour; MJ Yazdan Panah; AR Taheri; H Assadi
Volume 6, Issue 4 , 2003, , Pages 28-30
Abstract
Background: Vitiligo is a common autoimmune skin disease that may occur in association with other autoimmune disorders especially those of the endocrine system. Diabetes mellitus is a common endocrine disease associated with vitiligo. Objective: To study the association of vitiligo and diabetes mellitus. ...
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Background: Vitiligo is a common autoimmune skin disease that may occur in association with other autoimmune disorders especially those of the endocrine system. Diabetes mellitus is a common endocrine disease associated with vitiligo. Objective: To study the association of vitiligo and diabetes mellitus. Patients and Methods: In this descriptive cross-sectional study, 750 diabetic patients referred to Mashhad Diabetes Center were studied in Shahrivar 1380. Results: Thirty-two (4.3%) of these patients suffered from vitiligo that mostly was of generalized type. The face was the most common site of involvement. Twenty-two patients (68.7%) were female and 10 patients (31.3%) were male. Five percent of female and 3.3% of male diabetics suffered from vitiligo. 4.2% of NIDDM diabetics and 4.7% of IDDM diabetics suffered from vitiligo. Conclusion: Vitiligo was more common in NIDDM than IDDM because of the higher prevalence of NIDDM, but the association of vitiligo with IDDM was stronger. Vitiligo was more common in female than male diabetics.