Rohit Singla; Kritika Singla; Saurabh Swaroop Gupta; Sanjeev Gupta; Aneet Mahendra; Akriti Gakhar
Abstract
Background: Multiple studies indicate the correlation between lichen planus (LP) and certain systemic disorders. Data suggest an increased incidence of dyslipidemia with LP. Abnormal lipid levels are major risk factors for developing atherosclerotic changes and cardiovascular disorders (CVD). Non-high-density ...
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Background: Multiple studies indicate the correlation between lichen planus (LP) and certain systemic disorders. Data suggest an increased incidence of dyslipidemia with LP. Abnormal lipid levels are major risk factors for developing atherosclerotic changes and cardiovascular disorders (CVD). Non-high-density lipoprotein cholesterol (non-HDL-C) is a reliable marker for cardiovascular events. If non-HDL-C levels are raised in LP patients, it would mean that these individuals are high-risk patients and should be investigated periodically. We aimed to find non-HDL-C serum levels in cases of lichen planus and compare them with controls.Methods: We compared lipid profiles between 100 cases of LP and 50 healthy controls.Results: Non-HDL-C levels were significantly higher in cases than controls (P = 0.002). The non-HDL-C level was elevated in 67% of LP cases, compared to 42% of controls.Conclusions: We demonstrated higher levels of non-HDL-C in LP patients than in controls, confirming the increased risk of CVDs in LP patients.
Saman Mohammadi; Nasim Askari; Maryam Khalili; Rezvan Amiri; Mahin Aflatoonian
Abstract
Background: The increased prevalence of metabolic syndrome has been established in chronic inflammatory skin diseases. Patients with metabolic syndrome have a higher mortality rate due to cardiovascular disease and malignancy. In this study, the prevalence of metabolic syndrome was evaluated in lichen ...
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Background: The increased prevalence of metabolic syndrome has been established in chronic inflammatory skin diseases. Patients with metabolic syndrome have a higher mortality rate due to cardiovascular disease and malignancy. In this study, the prevalence of metabolic syndrome was evaluated in lichen planus patients compared with a control group in Kerman, southeast Iran.Methods: This was a cross-sectional study on 90 patients with lichen planus and 90 healthy participants from the Dermatology Clinic of Afzalipour Hospital, Kerman, Iran. Demographic features of the patients and clinical features of the lesions were recorded. Then, parameters of metabolic syndrome were evaluated in both groups. The independent t-test and chi-squared test were used to compare quantitative and qualitative variables, respectively.Results: There was no significant difference in demographic features of the participants between the two groups. Metabolic syndrome was significantly more prevalent in the lichen planus group (62.6%) than in the control group (14.4%) (P = 0.001). Metabolic syndrome parameter values (except waist circumference) were significantly higher in the lichen planus group than in the control group. Lichen planus patients with metabolic syndrome had a significantly higher percentage of mucosal involvement (66.1%) than lichen planus patients without metabolic syndrome (44.1%). Lichen planus patients with metabolic syndrome were significantly older than those without metabolic syndrome.Conclusions: This study observed a higher prevalence of metabolic syndrome in lichen planus patients relative to controls. Furthermore, lichen planus patients with metabolic syndrome had significantly higher age, mucosal involvement, and body mass index than lichen planus patients without metabolic syndrome.
Maryam Nasimi; vahide Lajevardi; Hamidreza Mahmoudi; Fatemeh Arbab; Safoura Shakoei
Abstract
Background: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology. There is conflicting data on the link between LP and metabolic syndrome. This study evaluated the association of chronic subtypes of LP, namely oral lichen planus and lichen planopilaris (LPP), with metabolic syndrome.Methods: ...
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Background: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology. There is conflicting data on the link between LP and metabolic syndrome. This study evaluated the association of chronic subtypes of LP, namely oral lichen planus and lichen planopilaris (LPP), with metabolic syndrome.Methods: In this cross-sectional study, 66 patients with oral and follicular LP were evaluated for metabolic syndrome based on the US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria and were compared against 66 healthy controls. Waist circumference, body mass index (BMI), systolic and diastolic blood pressure, fasting blood sugar (FBS), and lipid profile were measured for each individual.Results: There was no significant difference in the prevalence of metabolic syndrome (13 [19.7%] vs. 8 [12.1%]; P = 0.23) and dyslipidemia (51 [77.3%] vs. 49 [74.2%]; P = 0.68) between the study groups. These findings remained statistically insignificant in both genders. The waist circumference (P = 0.008) and diastolic blood pressure (DBP) (P = 0.02) were significantly higher in the LP group than the healthy individuals. Our data showed that each unit increment in waist circumference and DBP leads to a 4.1% (P = 0.02) and 4.7% (P = 0.03) increase in the chance of LP,respectively.Conclusion: Patients with oral LP and LPP do not have a higher prevalence of metabolic syndrome or dyslipidemia than healthy individuals. However, they are more vulnerable to central obesity and high diastolic pressure, for which they should be routinely screened.
Yalda Nahidi; Naser Tayyebi Meibodi; Pooran Layegh; Sara Sharifi
Abstract
Background: Lichen planus (LP) is a chronic inflammatory disease involving the skin, mucous membranes and appendages. Like other chronic inflammatory diseases, it may be associated with metabolic disorders and dyslipidemia. Due to the discrepancies in the results of previous studies and lack of a similar ...
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Background: Lichen planus (LP) is a chronic inflammatory disease involving the skin, mucous membranes and appendages. Like other chronic inflammatory diseases, it may be associated with metabolic disorders and dyslipidemia. Due to the discrepancies in the results of previous studies and lack of a similar study on an Iranian population, we decided to investigate and compare the serum lipid levels of LP patients and normal healthy subjects.Methods: In this case-control study, 71 patients with lichen planus confirmed by clinical and pathological examination who referred to dermatology clinic were recruited; further included were 71 subjects selected from attendants without any skin diseases matched for age, gender and BMI.with patients; the well-being of the healthy subjects was confirmed by laboratory tests, physical examination and medical history..After filling the questionnaire, triglyceride, cholesterol, HDL and LDL levels were measured for patients and healthy subjects..The collected data were then analyzed.Results: Mean age of patients in the case group was 40.63 ± 11.41 years, 50.6% of whom were men, while 49.4% were women. Cholesterol, triglyceride and LDL levels in patients were significantly higher than the control group; it was only regarding HDL levels that no significant difference was observed between the two groups. HDL and triglyceride levels were significantly higher in patients with generalized disease. There was a recognizable correlation between elevated levels of LDL and cholesterol and disease duration.Conclusions: In this study, a disrupted lipid profile was observed in LP patients, which can be associated with disease severity. This study proposes measuring lipid serum levels prior to commencing the treatment in all known cases of lichen planus so as to preclude cardiovascular diseases if there is a problem with the lipid profile.
Yaghoobi Reza; Pazyar Nader; Kalantari Hooman
Volume 20, Issue 1 , 2017, , Pages 11-14
Abstract
Background: Lichen planus (LP) is a chronic inflammatory skin condition which leads to changes in lipid metabolism. It may cause chronic atherosclerosis and metabolic syndrome. Theobjective of this study is to compare lipid levels of patients with LP to healthy controls. Methods: This case-control study ...
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Background: Lichen planus (LP) is a chronic inflammatory skin condition which leads to changes in lipid metabolism. It may cause chronic atherosclerosis and metabolic syndrome. Theobjective of this study is to compare lipid levels of patients with LP to healthy controls. Methods: This case-control study recruited 100 total participants, 50 (25 male and 25 female) patients with LP and 50 healthy controls admitted to the Dermatology Clinic of Imam Hospital, Ahvaz, Iran. Serum triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol levels were measured in samples drawn after a 12-hour fasting period. Results: Patients with LP had significantly higher triglycerides (147.7 vs. 118.4 mg/dl, P<0.05), total cholesterol (188 vs. 173 mg/ dl, P<0.05), LDL (122 vs. 106 mg/dl, P<0.05), and lower HDL (49 vs. 57 mg/dl, P<0.05) levels compared to controls. Conclusion: This study showed an association between LP and dyslipidemia. Screening of serum lipids in patients with LP might be valuable to prevent cardiovascular diseases.
