Samaneh Mozafarpoor; Ali Asilian; Mohammad Amin Jafari; Azadeh Goodarzi
Abstract
Recessive dystrophic epidermolysis bullosa (RDEB) is an autosomal recessive disorder that affects type VII collagen, one of the main components of the basement membrane. Patients present with non-healing chronic wounds in the body, extremities, and mucosal areas. There are many suggestive medical and ...
Read More
Recessive dystrophic epidermolysis bullosa (RDEB) is an autosomal recessive disorder that affects type VII collagen, one of the main components of the basement membrane. Patients present with non-healing chronic wounds in the body, extremities, and mucosal areas. There are many suggestive medical and surgical treatments, but most are ineffective. In this case, we discuss a new laserassisted surgical protocol for these types of patients. A 54-year-old male patient was suffering from RDEB with large, excruciating, non-healing wounds on his extremities dating ten months, with no reasonable improvement, despite receiving intensive wound care. After ruling out other diagnoses (particularly malignancies), treatment was performed with a fractional Er:YAG laser for a single session. After four weeks of follow-up, the patient showed significant improvement, with no considerable complications reported. Fractional ablative Er:YAG laser could be an effective treatment option in RDEB patients. Clinical trials are required with long-term follow-ups for this novel treatment approach.
Samaneh Mozafarpoor; Ali Asilian; Azadeh Goodarzi; Zahra Ebrahimi; Fatemeh Mokhtari; Zeynab Rastgar Moqaddam
Abstract
Lymphangioma is an unusual congenital malformation of the lymphatic system that affects the skin and subcutaneous tissue. A surgical procedure is among the options for lymphangioma treatment, although it can lead to significant complications. The Nd:YAG Laser appears to be one of the safest therapeutic ...
Read More
Lymphangioma is an unusual congenital malformation of the lymphatic system that affects the skin and subcutaneous tissue. A surgical procedure is among the options for lymphangioma treatment, although it can lead to significant complications. The Nd:YAG Laser appears to be one of the safest therapeutic options rarely proposed to treat oral cavity lesions. This paper comprehensively reviewed the studies published from 2010 to date on the treatment of cutaneous and mucosal lymphangioma with different types of lasers. In the current report, an 18-yearold female presented with a lymphangiomatous lesion on the tongue diagnosed through a pathologic study. The patient initiallyunderwent three sessions of pulsed-dye laser (PDL) therapy that evoked an insignificant response. Therefore, the approach was changed to long-pulsed Nd:YAG laser therapy, and a dramatic response was observed within three sessions of the treatment.
Samadi Zaynab; Gorouhi Farzam; Davari Parastoo; Firooz Alireza
Volume 9, Issue 4 , 2006, , Pages 335-342
Abstract
Background and aim: Pemphigus vulgaris (PV) is the most common blistering disease in Iran and many other Asian countries with a relatively high incidence and involvement of both skin and mucous membrances in majority of patients. The aim of this study was to assess the opinions of Asian experts on the ...
Read More
Background and aim: Pemphigus vulgaris (PV) is the most common blistering disease in Iran and many other Asian countries with a relatively high incidence and involvement of both skin and mucous membrances in majority of patients. The aim of this study was to assess the opinions of Asian experts on the diagnosis and management of PV. Materials and Methods: A questinnaire-based mailed/emailed survey was conducted. The questionnaire was sent to 29 dermatologists from different countries of Asia (23 from Iran and 6 from India, Kuwait, Turkey and Bangladesh) who are in charge of the treatment of autoimmune blistering disorders with at least 5 years experience in this field who visit at least five new PV patients annually. Questions incluced duration of experience, number of patients treated and diagnostic and treatment approaches for PV. Descriptive data were reported using SPSS 11.5 and some data are reported as mean±SD. Results: All 29 physicians participated in the survey. Among them, 79.3% visit their patients within 6 months after the onset of symptoms. Diagnosis of PV is confirmed by histologic and direct immunofluorescence examinations by 65.5% of physicians. All of them initiate the treatment with corticosteroids (48.3% with a dose of at least 2 mg/kg/day prednisolone) and 89.7% add adjuvant immunosuppressors at the same time. Of the adjuvant agents used, azathioprine is used by 82.8% of physicians. Conclusion: Different trends in diagnostic techniques and treatment options for PV among the experienced authorities emphasize the urgent need for large-scale controlled trials to reach consensus standards in this field. In addition, regional and worldwide consensus meetings to consider all regional and genetic similarities and differences are highly recommended.
S Shamsedini; S Rajab Alian; M Mirzaei; M Brofei
Volume 9, Issue 2 , 2006, , Pages 173-178
Abstract
Background and aim: Leishmaniasis is a zoonotic disease with wide clinical diversity caused by protozoan parasite belonging to the genus of Leishmania. Treatment of human leishmaniases are still based on pentavalent antimonials but their toxicity and emerging resistance are problematic. This study was ...
Read More
Background and aim: Leishmaniasis is a zoonotic disease with wide clinical diversity caused by protozoan parasite belonging to the genus of Leishmania. Treatment of human leishmaniases are still based on pentavalent antimonials but their toxicity and emerging resistance are problematic. This study was performed to assess the effect of Mimosa tenuiflora extract on L. tropica promastigotes to find potential new therapeutic method against leishmaniasis.Materials and Methods: This study has been based on two in vitro methods: methyl thiazole tetrazolium (MTT) assay and counting parasites, using 10, 100, 500, 1000 micg/ml concentrations of plant extract.Results: Different concentrations of M. Tenuiflora extract have different effects on multiplication of Leishmania protozoa in culture medium. Concentration of 1000 and 500 micg/ml suppressed multiplication of promastigotes but at a concentration of 100 micg/ml it accelerated growth of promastigotes.Conclusion: This finding suggested that M. tenuiflora extract contains both inhibitory and acceleratory effects on Leishmania growth in vitro.
N Motamed; B Pour Dadash
Volume 8, Issue 5 , 2005, , Pages 408-418
SK Alavi Fazel; SM Radmanesh
Volume 2, Issue 2 , 1999, , Pages 34-38
Abstract
Hypnotherapy is recommended for recalcitrant cases of many dermatologic disorders including viral warts, chronic urticarias, psoriasis and alopecia areata. A 23-year old, married lady referred with five years history of confluent verrucous and cauliflower type of viral warts on the dorsum of right foot ...
Read More
Hypnotherapy is recommended for recalcitrant cases of many dermatologic disorders including viral warts, chronic urticarias, psoriasis and alopecia areata. A 23-year old, married lady referred with five years history of confluent verrucous and cauliflower type of viral warts on the dorsum of right foot and many discrete warty papules on the left foot and toes and on different aspects of both hands and fingers. She had tried many medical modalities and surgical procedures including: keratolytics, formalin application, electrocauterization, curettage, cryotherapy with no satisfactory effect. As the patient was quite frustrated with no more trust on physical therapies, she was advised to be treated by hypnotherapy. After patient’s consent, she was scheduled for 20 hypnotherapy sessions with weekly interval. The papules on the hands disappeared after the second session and those of the right foot started to improve after the tenth session. Complete eradication occurred before the 20th session. Although hypnotherapy is time consuming, it is recommended for recalcitrant cases of viral warts.