Nasrin Saki; Mina Bazyar Sarani; Fatemeh Sari Aslani; Mohammad Mahdi Parvizi
Abstract
Primary cutaneous diffuse large B‐cell lymphoma-leg type (PCDLBCL‐LT) is a rare malignant disease seen in older adults, especially women. In this case report, we discuss a 78-year-old man who developed erythematous indurated plaques on his left shin for about three months. The patient did not report ...
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Primary cutaneous diffuse large B‐cell lymphoma-leg type (PCDLBCL‐LT) is a rare malignant disease seen in older adults, especially women. In this case report, we discuss a 78-year-old man who developed erythematous indurated plaques on his left shin for about three months. The patient did not report pruritus, weight loss, night sweats, fever, or chills. There was no lymphadenopathy, splenomegaly, or hepatomegaly on the physical examination. A local tissue biopsy was taken from the plaques, confirming the diagnosis of PCDLBCL‐LT via immunohistochemistry. The patient was referred to an oncologist to begin additional evaluation and treatment. According to the literature, chemotherapy with or without adjuvant radiotherapy is the first treatment choice for PCDLBCL‐LT. Monotherapy with rituximab could be considered in some patients with this condition, but the disease may relapse in a short period.
Fatemeh Parvizifard; Massoumeh Zargaran; Verisheh Rastin
Abstract
Background: Basal cell carcinoma (BCC), the most common human malignancy, can cause significant morbidity through extensive tissue destruction. This study aimed to determine the frequency and clinicopathological features of BCC in an Iranian population.Methods: Histopathological reports with a definitive ...
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Background: Basal cell carcinoma (BCC), the most common human malignancy, can cause significant morbidity through extensive tissue destruction. This study aimed to determine the frequency and clinicopathological features of BCC in an Iranian population.Methods: Histopathological reports with a definitive diagnosis of BCC in all pathology centers of Sanandaj, Kurdistan province, during 2009–2019 were reviewed. Data on age, gender, site, size, and clinical and histopathological types of tumors were collected and analyzed using SPSS software. P-values < 0.05 were consideredsignificant.Results: We found 832 BCC lesions in 779 patients, including 453 males and 326 females aged 65.36 ± 14.35 years and 62.77 ± 13.79 years, respectively. The mean tumor size was 14.52 ± 10.08 mm in men and 11.79 ± 7.89 mm in women. The most common location was the head (95.23%), with the nose representing the most involved area. Males and females differed regarding age (P = 0.012), tumor size (P < 0.001), and the anatomical distribution of tumors on various parts of the head (P < 0.001). Ulcerative (58.36%) and nodular (54.45%) BCCs were the most frequent clinical and histopathological types, respectively, both in males and females, without a significant difference between the genders (P > 0.05).Conclusions: Our findings suggest that age, gender, and the tumor site in various head areas could be risk factors for BCC. Appropriate knowledge of BCC and its risk factors can help design prevention strategies and provide the necessary training for healthcare staff and the public to identify the disease in susceptible individuals.
Kaliaperumal Karthikeyan; Iswarya Arumugam; Vijayasankar Palaniappan
Abstract
Porokeratosis is a heterogeneous group of keratinization disorderswith an autosomal dominant inheritance pattern. The etiology andpathogenesis of this disease have not been completely elucidated.The porokeratosis clinically presents with a characteristic prominentperipheral ridge and central dell. The ...
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Porokeratosis is a heterogeneous group of keratinization disorderswith an autosomal dominant inheritance pattern. The etiology andpathogenesis of this disease have not been completely elucidated.The porokeratosis clinically presents with a characteristic prominentperipheral ridge and central dell. The histological feature of theparakeratotic column known as ‘cornoid lamellae’ is a hallmarkfeature observed in the peripheral rim. Among the variousmorphological forms, linear porokeratosis is a rare variant withfour subtypes. When compared to other forms, the linear variantcarries an increased risk of malignancy, particularly squamouscell carcinoma, warranting a regular follow-up. Though there aremultiple treatment options, achieving complete clinical resolutionis difficult. We report an interesting case of linear porokeratosiswith generalized lesions in a 60-year-old male. The lesions weretypical and predominantly distributed in the extremities. Thebiopsy was diagnostic in our patient. This case is reported forits rare presentation and clinical interest.
Ali Asilian; Samaneh Mozafarpoor; Azadeh Goodarzi; Mohammad Amin Jafari; Parvin Rajabi; Mehdi Eftekhari
Abstract
Composite hemangioendothelioma (CHE) is a rare and little-known condition with combined benign, intermediate, and malignant features. In the current study, we describe the case of a young female with the presentations of CHE, representing the second known case in Iran. Also, we have comprehensively reviewed ...
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Composite hemangioendothelioma (CHE) is a rare and little-known condition with combined benign, intermediate, and malignant features. In the current study, we describe the case of a young female with the presentations of CHE, representing the second known case in Iran. Also, we have comprehensively reviewed previous case reports of CHE. A 30-year-old female was referred with a reddish hemorrhagic painless mass in the small right finger that appeared within a few days following trauma. The mass was primarily excised but recurred within three weeks; therefore, she underwent thorough clinical, laboratory, and imaging studies. Finally, the lesions were biopsied and diagnosed as CHE. Accordingly, the involved finger was amputated, and the patient underwent chemoradiotherapy. Although CHE is a rare malignant condition worldwide, attention to the clinical presentations of this malignancy can help scientists make better therapeutic approaches leading to the best outcomes.
R Yaghoobi; AA Aliari; N Emad Mostovfi; SM Latifi
Volume 8, Issue 1 , 2004, , Pages 24-31
Abstract
Background: The incidence of oral cancers is different worldwide. Objective: To evaluate the rate of oral cancers in Khouzestan Province. Patients and Methods: The data were collected from the pathologic reports of pathology laboratories all around the province, during the time period of 1992-2002. Results: ...
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Background: The incidence of oral cancers is different worldwide. Objective: To evaluate the rate of oral cancers in Khouzestan Province. Patients and Methods: The data were collected from the pathologic reports of pathology laboratories all around the province, during the time period of 1992-2002. Results: Among the total received specimens, 305 cases of oral cancers were detected. One hundred ninety-three cases (63.2%) were male and 112 cases (36.8%) were female. Male to female ratio was 1.7 and mean age was 55.04±16.60 years. Squamous cell carcinoma was the most common malignancy (75% of total), and then standed the nasopharyngeal carcinoma (10.8%) and lymphoma (7.5%). The most common sites were lower lip (29.2%), tongue (19%) and nasopharynx (15.7%). Conclusion: Regardless of some minor differences, most of our findings were similar to other previous studies.
M Seylanian Toosi; F Homaiee; HR Raziee
Volume 7, Issue 4 , 2004, , Pages 242-246
Abstract
Background: Neurofibromatosis 1 (NF1) is a relatively common autosomal dominant condition. Among the complications of the disease, such as neurological disorders, hypertension and skeletal deformities, malignancy is the most serious one and is the main cause of early death in these patients. Objective: ...
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Background: Neurofibromatosis 1 (NF1) is a relatively common autosomal dominant condition. Among the complications of the disease, such as neurological disorders, hypertension and skeletal deformities, malignancy is the most serious one and is the main cause of early death in these patients. Objective: Review of cases of NF-1 associated with malignancies. Patents and Methods: In a retrospective, descriptive study, 17 patients with malignancy and NF1 disease referred to oncology department of Qaem and Omid Hospitals (Mashhad) in a 10-year-period between 1993 and 2003 were reviewed. Results: 11 patients were male and 6 were female. The median age of patients was 23 years. We observed 9 cases with malignant peripheral nerve sheath tumors, 4 with CNS malignancies, 2 with rhabdomyosarcoma and one case with breast carcinoma. Conclusion: Regarding the importance of early diagnosis of these malignancies, and especially considering the young age of involved patients, it is logical to plot a schedule to examine the NF1 patients periodically. Physicians who are in contact with these patients should educate them to be aware of any suspicious signs and symptoms of malignancy.
R Yaghoobi; N Sina; K Saedi
Volume 6, Issue 3 , 2003, , Pages 39-43
Abstract
Association of lichen planus and cutaneous malignancies is rare. Reports of neoplastic changes are mostly related to buccal chronic erosive lichen planus. We report herein a 29-year-old man who developed squamous cell carcinoma on previous lesions of chronic hypertrophic lichen planus of lower legs. ...
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Association of lichen planus and cutaneous malignancies is rare. Reports of neoplastic changes are mostly related to buccal chronic erosive lichen planus. We report herein a 29-year-old man who developed squamous cell carcinoma on previous lesions of chronic hypertrophic lichen planus of lower legs. Careful follow up of patients with chronic lichen planus and biopsy sampling of uncommon lesions is required to rule out malignant transformation.