Jannan Ghapanchi; Maryam Zahed; Mohammad Javad Mokhtari; Mohammad Javad Fattahi; Fahimeh Rezazadeh; Nafiseh Moshtaghi
Abstract
Background: This study aimed to assess the single nucleotide polymorphisms (SNPs) of lncRNA (long non-coding RNA) H19 rs217727 in patients with oral lichen planus (OLP) compared to controls.Methods: We collected 270 DNA samples of OLP cases and healthy individuals. We used the ARMS-PCR tetra primer for ...
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Background: This study aimed to assess the single nucleotide polymorphisms (SNPs) of lncRNA (long non-coding RNA) H19 rs217727 in patients with oral lichen planus (OLP) compared to controls.Methods: We collected 270 DNA samples of OLP cases and healthy individuals. We used the ARMS-PCR tetra primer for DNA genotyping and applied specific primer pairs.Results: The prevalence of the rs217727 C allele was lower in OLP cases than in healthy subjects (P = 0.005). The prevalence of TT genotypes of H19 rs217727 was greater in OLP patients compared with healthy subjects (5.71% vs 1.5%). Also, the TT genotype in the codominant model was associated with a 5.15-fold higher risk of OLP (P = 0.02). In the dominant model, the CT+TT genotypes were associated with a 2.09-fold greater risk of OLP (P = 0.007). The H19 rs217727 polymorphism was linked to a 3.95-fold greater risk of OLP in the recessive model (P = 0.05) (TT vs. CC+CT).Also, in the over-dominant model, the CT genotypes were related to a 1.78-fold greater risk of OLP (P = 0.03).Conclusion: This study demonstrated a significant link between lncRNA H19 polymorphism and OLP lesions. Further studies on larger populations are necessary to confirm this relationship.
Maryam Nasimi; vahide Lajevardi; Hamidreza Mahmoudi; Fatemeh Arbab; Safoura Shakoei
Abstract
Background: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology. There is conflicting data on the link between LP and metabolic syndrome. This study evaluated the association of chronic subtypes of LP, namely oral lichen planus and lichen planopilaris (LPP), with metabolic syndrome.Methods: ...
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Background: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology. There is conflicting data on the link between LP and metabolic syndrome. This study evaluated the association of chronic subtypes of LP, namely oral lichen planus and lichen planopilaris (LPP), with metabolic syndrome.Methods: In this cross-sectional study, 66 patients with oral and follicular LP were evaluated for metabolic syndrome based on the US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria and were compared against 66 healthy controls. Waist circumference, body mass index (BMI), systolic and diastolic blood pressure, fasting blood sugar (FBS), and lipid profile were measured for each individual.Results: There was no significant difference in the prevalence of metabolic syndrome (13 [19.7%] vs. 8 [12.1%]; P = 0.23) and dyslipidemia (51 [77.3%] vs. 49 [74.2%]; P = 0.68) between the study groups. These findings remained statistically insignificant in both genders. The waist circumference (P = 0.008) and diastolic blood pressure (DBP) (P = 0.02) were significantly higher in the LP group than the healthy individuals. Our data showed that each unit increment in waist circumference and DBP leads to a 4.1% (P = 0.02) and 4.7% (P = 0.03) increase in the chance of LP,respectively.Conclusion: Patients with oral LP and LPP do not have a higher prevalence of metabolic syndrome or dyslipidemia than healthy individuals. However, they are more vulnerable to central obesity and high diastolic pressure, for which they should be routinely screened.
Ensieh Lotfali; Alireza Firooz; Azam Fattahi; Mojgan Borzouie; Behzad Chalaki; Reza Ghasemi; Mohammad Mahdi Rabiei; Sareh Farhadi; Seyed Amirfarshad Esteghamat; Mobina Habibollahi
Abstract
Oral lichen planus (OLP) is a mucocutaneous disease characterized by inflammation leading to severe damage to the epithelial basal layer. This report describes a case of a 65-year-old Iranian female with a complaint of multifocal white lesions on the buccal and tongue mucosa with a reticular pattern ...
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Oral lichen planus (OLP) is a mucocutaneous disease characterized by inflammation leading to severe damage to the epithelial basal layer. This report describes a case of a 65-year-old Iranian female with a complaint of multifocal white lesions on the buccal and tongue mucosa with a reticular pattern and a focal pseudomembranous appearance (similar to thrush), together with burning symptoms for fourteen months. The patient was using topical fluocinolone acetonide 0.1%, two to three times a day at least for six months to control the ulcers and erythema. Molecular analysis of the thrush sample revealed Candida glabrata as the causative agent. Histopathologic examination confirmed the diagnosis of OLP. The minimum inhibitory concentration analysis was performed according to CLSI-M60 and revealed that this C. glabrata isolate was multidrug-resistant (resistant to nystatin, fluconazole, micafungin, and caspofungin). Finally, this patient was treated with amphotericin B oral suspension (0.5 g/5 ml) thrice daily for 14 days. The thrush disappeared completely and the patient no longer had any pain or burning sensations. Candida glabrata, the second most common cause of candidemia, is a major opportunistic fungal pathogen of humans that causes systemic as well as, mucosal and superficial infections. This case is the first case of OLP accompanied by multidrug-resistant C. glabrata.
