Dadras Mohammad Shahidi; Golfeshan Atefeh; Younespour Shima
Volume 18, Issue 1 , 2015, , Pages 16-19
Abstract
Background: The ABO blood group antigens play a role in thepathophysiology of some diseases and several researches haveinvestigated this relationship in the field of dermatology. In thepresent study, an attempt was made to find the distribution ofblood types in patients with pemphigus vulgaris and chronicplaque ...
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Background: The ABO blood group antigens play a role in thepathophysiology of some diseases and several researches haveinvestigated this relationship in the field of dermatology. In thepresent study, an attempt was made to find the distribution ofblood types in patients with pemphigus vulgaris and chronicplaque type psoriasis.Method: Fifty patients with chronic plaque type psoriasis, 50patients with pemphigus vulgaris and 100 healthy persons ascontrol group, were selected as the study population. ABO bloodgrouping was determined by the cell type tube test method, usingstandard commercial anti/A, anti/B and 5% suspension of redblood cells. Chi square test was used to compare the frequencyof ABO blood groups in patients and control groups.Result: Among the 50 patients with psoriasis, 21 (42%) hadblood group O, 15 (30%) blood group A, 10 (20%) blood groupB and 8 (4%) had blood group AB. Among the 50 patients in thepemphigus group, 22 (44%) had blood group O, 19 (38%) bloodgroup A, 8 (16%) blood group B and 1 (2%) had blood groupAB. The distribution of blood groups in patients with these twodiseases was not significantly different from the control group.Conclusion: Despite some researches, which found associationsbetween blood group antigens and psoriasis or pemphigus, thisstudy did not find any such relationship.
Hussain Sajjad; Hassan Iffat; Majeed Sabiya; Showkat A Bhat; Hinah Altaf; Peerzada Sajad
Volume 17, Issue 4 , 2014, , Pages 117-121
Abstract
Background: Psoriasis is a chronic inflammatory disease of theskin. The etiology of psoriasis is not known exactly. Recently, ithas been suggested that an imbalance in the oxidant- antioxidantstatus due to an increased reactive oxygen species production and/or deficient function of the antioxidant system ...
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Background: Psoriasis is a chronic inflammatory disease of theskin. The etiology of psoriasis is not known exactly. Recently, ithas been suggested that an imbalance in the oxidant- antioxidantstatus due to an increased reactive oxygen species production and/or deficient function of the antioxidant system may be involvedin the pathogenesis of psoriasis. The aim of this study was toevaluate the antioxidant defense status in patients with psoriasisand to look for a correlation, if any, between the antioxidantdefense status and the severity of psoriasis.Method: Sixty patients with psoriasis and an equal number ofage and sex matched healthy controls were enrolled in the study.Plasma levels of malondialdehyde (MDA), reduced glutathione(GSH), and superoxide dismutase (SOD), and antioxidant potential(AOP) were measured in cases as well as controls.Result: Patients with psoriasis were found to have significantlyhigher levels of plasma SOD (P < 0.001) and MDA (P < 0.001)and lower levels of GSH (P < 0.001) than controls. Plasma AOPwas not significantly different between patients and controls(P= 0.822).Conclusion: The results of our study support the hypothesisof an imbalance in the oxidant –antioxidant status in psoriasis,which could contribute to the pathogenesis of psoriasis.
Tehranchinia Zohreh; Niroomand Mahtab; Kazeminejad Armaghan; Ghahari Mohammad Jafar; Radvar Siamak Esmaeili; Sadat-Amini Seyed Hadi; Younespour Shima; Partovi-Kia Masoud
Volume 17, Issue 2 , 2014, , Pages 43-48
Abstract
Background: Leptin, a 16-KDa peptide hormone secreted from theadipose tissue, plays an important role in the regulation of energyintake and expenditure and body weight regulation; furthermore,it has a regulatory function on the reproductive system. The aimof this study was to assess the relationship ...
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Background: Leptin, a 16-KDa peptide hormone secreted from theadipose tissue, plays an important role in the regulation of energyintake and expenditure and body weight regulation; furthermore,it has a regulatory function on the reproductive system. The aimof this study was to assess the relationship between serum leptinlevels and sex hormones in psoriatic patients and control groupand to determine the serum levels of leptin and sex hormones inpatients and their association with disease severity.Method: This cross-sectional study included 43 male patientswith psoriasis and 42 age- and sex- matched healthy controls. Wemeasured serum levels of leptin, sex hormone-binding globulin(SHBG), luteinizing hormone (LH), follicle stimulating hormone(FSH), prolactin, and total testosterone in both groups.Result: Psoriatic patients had si
Handjani Farhad; Kalafi Amir
Volume 16, Issue 4 , 2013, , Pages 128-131
Abstract
Background: Chronic skin diseases such as vitiligo and psoriasis can impair the quality of life in the patients with these diseases. The impact of chronic and/or severe skin diseases on the lives of family members of the affected patients has only recently been addressed. The tool used for this assessment ...
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Background: Chronic skin diseases such as vitiligo and psoriasis can impair the quality of life in the patients with these diseases. The impact of chronic and/or severe skin diseases on the lives of family members of the affected patients has only recently been addressed. The tool used for this assessment is the Family Dermatology Life Quality Index (FDLQI). The aim of this study was to use the FDLQI to assess the impact of four skin diseases (pemphigus, psoriasis, vitiligo, and cutaneous leishmaniasis) on family members of the affected patients.Method: Fifty healthy family members of 50 patients with pemphigus, psoriasis, vitiligo, and cutaneous leishmaniasis were included in this study. The patients had to have an extensive disease with disease duration of at least one month. One family member of each patient completed the 10- item Persian version of the FLDQI questionnaire. The score of this index ranged from 0 to 30.Result: The mean duration and mean FDLQI score of the diseases were as follows: psoriasis (mean duration=4.1±2.7, mean FDLQI score=14.7±5.01), pemphigus (mean duration=3.6±2.3, mean FDLQI score=15.4±4.7), vitiligo (mean duration=5.1±4.05, mean FDLQI score=14.4±5.08) and cutaneous leishmaniasis (mean duration=0.62±0.23, mean FDLQI score=12.0±4.3). There was no significant difference among the groups (p=0.562). In addition, no strong correlation was observed between the mean duration of the disease and mean FDLQI scores for each condition (r=0.051, p=0.726).Conclusion: This small-scale study demonstrated that although not statistically significant, inflammatory diseases like pemphigus had a higher FDLQI score when compared to non-inflammatory conditions like vitiligo and short-term conditions such as leishmaniasis.
Balighi Kamran; Soori Tahereh; Fouladi Negar
Volume 16, Issue 3 , 2013, , Pages 105-108
Abstract
Background: Mucocutaneous manifestations may occur inevery stage of human immunodeficiency virus (HIV) infection.Some of them may be the first presentations. In this study, weevaluated the prevalence of dermatologic manifestations as thefirst presentations of HIV/AIDS in 25 Iranian patients.Method: In ...
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Background: Mucocutaneous manifestations may occur inevery stage of human immunodeficiency virus (HIV) infection.Some of them may be the first presentations. In this study, weevaluated the prevalence of dermatologic manifestations as thefirst presentations of HIV/AIDS in 25 Iranian patients.Method: In a cross sectional study, we evaluated 25 new casesof HIV infection whose HIV infections were diagnosed duringwork up for their recent dermatological problems. The type ofmucocutaneous manifestations and general information suchas age, sex, risk factors, dermatologic problem duration andeducational level was recorded in a questionnaire.Result: Warts (anogenital and generalized warts) were the mostcommon cutaneous manifestation in new HIV infected patients(36%) followed by psoriasis and cutaneous abscess.Conclusion: Some mucocutaneous diseases such as anogenital orgeneralized warts, psoriasis, and cutaneous abscess may presentas the first manifestation of HIV infection.
Shahidi-Dadras Mohammad; Namazi Nastaran; Khalilazar Sara; Younespour Shima
Volume 15, Issue 2 , 2012, , Pages 38-41
Abstract
Background: Psoriasis is a common and chronic inflammatory skin disease that has profound adverse effects on patients’ wellbeing. Trace elements are essential to biochemical processes in the body and are involved in immunological and inflammatory reactions such as keratinization and melanin formation. ...
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Background: Psoriasis is a common and chronic inflammatory skin disease that has profound adverse effects on patients’ wellbeing. Trace elements are essential to biochemical processes in the body and are involved in immunological and inflammatory reactions such as keratinization and melanin formation. The aim of this study was to evaluate the essential metals in psoriasis in comparision with healthy controls. Method: We investigated serum levels of zinc, copper, and magnesium in 40 psoriatic patients and age and sex matched controls. Result: Psoriatic patients showed significantly higher serum levels of copper / zinc and lower magnesium in comparison with the control group. No significant differences were seen in copper and zinc levels. There was no correlation between serum levels of these elements and psoriasis severity except for zinc; the serum level of zinc was inversely correlated with psoriasis severity. Conclusion: This study demonstrated some disturbances in serum levels of metals in psoriasis. More studies are required to clarify the importance of these findings in etiopathogenesis or treatment.
Najmossadat Atefi; Mehdi Tabaie; Samile Noorbakhsh; Azarmidokht Tabatabaie; Mohammadreza Rezaee; Masomeh Rohaninasab
Volume 15, Issue 1 , 2012, , Pages 1-3
Abstract
Background: T cell activation is discussed as an important factor in the pathogenesis of psoriasis. Recently, a lot of attention has been paid to the role of superantigens in T cell activation in the pathogenesis of psoriasis. In this study, the role of staphylococcal superantigens in the pathogenesis ...
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Background: T cell activation is discussed as an important factor in the pathogenesis of psoriasis. Recently, a lot of attention has been paid to the role of superantigens in T cell activation in the pathogenesis of psoriasis. In this study, the role of staphylococcal superantigens in the pathogenesis of psoriasis with identification of staphylococcal toxin levels in the skin lesions of patients with chronic plaque psoriasis has been studied. Method: In this case-control study, biopsies were taken from the skin of 40 patients with chronic plaque type psoriasis and 40 controls. Staphylococcal superantigens such as staphylococcus enterotoxin A, staphylococcus enterotoxin C, and toxic shock syndrome toxin 1 were investigated using polymerase chain reaction. Result: Staphylococcus aureus was isolated from 6.5% of the psoriasis patients and 2.5% of the individuals in the control group and all of them were toxin producer. There was a significant difference between controls and patients. Conclusion: Bacterial superantigens probably play an important role in the pathogenesis of chronic plaque type psoriasis.
Farhad Malekzad; Reza Robati; Hamidreza Abaei; Somayeh Hejazi; Azin Ayatollahi; Shima Younespour
Volume 14, Issue 4 , 2011, , Pages 136-139
Abstract
Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance.Methods: This single-centre, ...
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Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance.Methods: This single-centre, case- control study was performed between 2008 and 2010 to evaluate the metabolic state of thirty chronic plaque type psoriatic patients in comparison with the control group. The criteria of insulin resistance (Body Mass Index (BMI), Systolic Blood Pressure, Fasting Plasma Glucose, Oral Glucose Tolerance Test (OGTT), Serum Insulin and Lipid Profile) were assessed for each participant.Results: Thirty psoriatic patients with a mean disease duration of 3.94 + 2.96 years and 30 healthy controls were recruited for the study. Only one patient in each group filled the criteria of insulin resistance, and there was no significant difference between the two groups. The mean Fasting Plasma Glucose (FPG), Triglyceride (TG) and Systolic Blood Pressure (SBP) levels were significantly higher in psoriasis patients as compared to the controls (p=0.044, p=0.014 and p=0.001, respectively). In contrast, no statistically significant differences were observed in mean BMI, OGTT, insulin and HDL levels between the two groups.Conclusion: Despite the absence of any significant association between insulin resistance and psoriasis, it could be concluded that psoriasis may be an independent risk factor for diseases such as Ischemic Heart Disease (IHD) and Diabetes Mellitus (DM), hypertension and obesity.
Pouran Layegh; Hamid Reza Arshadi; Sara Shahriari; Fakhrolzaman Pezeshkpour; Yalda Nahidi
Volume 13, Issue 4 , 2010, , Pages 106-111
Abstract
Background: Due to their chronic nature, influences on the body image, hopelessness toward complete recovery and frequent recurrences, dermatological diseases seem to be one of the important predisposing factors in depression and suicidal ideation. Thus, the present study aimed at evaluating the degree ...
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Background: Due to their chronic nature, influences on the body image, hopelessness toward complete recovery and frequent recurrences, dermatological diseases seem to be one of the important predisposing factors in depression and suicidal ideation. Thus, the present study aimed at evaluating the degree of depression and suicidal ideation in patients with psoriasis, acne, alopecia areata and vitiligo.Methods: The study was carried out on 300 patients with psoriasis, acne, alopecia and vitiligo who were referred to the dermatology clinic of Ghaem Hospital in Mashad. Beck depression questionnaire was used to collect the data which was then statistically analyzed with ANOVA and T-test, using SPSS software.Results: In this study, 35.7% (107) of the subjects were female and 64.3% (193) were male with a mean age of 26.55±10.81 years. The prevalence rate of clinical depression was found to be 47.4% in patients with acne; 69.4% in those with psoriasis; 70.1% in those suffering from vitiligo; 50% in diffuse alopecia areata; 60% in universalis alopecia areata; 100% in ophiasis alopecia areata and 68.3% in patients with localized alopecia areata. As for suicidal ideation, there was no sign in 88.3% (265); however, 6.3% (19) of the patients reported to have thought of suicide but they had no desire for the attempt while 4% (12) of them had some desire for suicide and 1.3% (4) were seriously determined to commit suicide if only they would find themselves in an appropriate situation.Conclusion: As shown by the findings of the study, there was a close relationship between dermatological diseases and psychological factors; thus, it is important to immediately diagnose concurrent psychological effects, especially those of depression and suicidal ideation. We found that there was a significant relationship between the prevalence rate of dermatological conditions and psychological effects; i.e. depression (P=0.008) and suicidal ideation (P=0.001). We also found out that the rate of suicide attempt was highest among the patients with universalis alopecia, diffuse alopecia areata and vitiligo, respectively.
Ghalamkarpour Fariba; Saeedi Marjan; Hedayati Mehdi; Maarefat Afsaneh
Volume 13, Issue 1 , 2010, , Pages 9-11
Abstract
Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study ...
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Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study was to describe selected immunological changes, concerning adhesion molecules status (sEselectin, sP-selectin), in psoriasis and also their correlation with disease activity. Method: Serum levels of soluble E-selectin and soluble P-selectin were measured by enzyme-linked immunosorbent assay in 58 patients with psoriasis and 24 healthy control subjects. The relationships between these adhesion molecules and the Psoriasis Areaand Severity Index score were investigated. Result: There was a significant correlation between the serum soluble E-selectin levels and Psoriasis Area and Severity Index score. Conclusion: Soluble E-selectin serum levels correlate with the extent of psoriatic lesions and could be used as marker of the disease activity in psoriatic patients but this finding needs further modification.
Rahmati-Roudsari Mohammad; Saeedi Marjan; Eshghi Gholamreza
Volume 12, Issue 4 , 2009, , Pages 127-130
Abstract
Background: Controversial data concerning the elevation of serum angiotensin-converting enzyme in psoriasis are reported in the literature. In order to verify whether this abnormality exists in Iranian patients, we performed this study. Method: Serum angiotensin-converting enzyme level was measured in ...
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Background: Controversial data concerning the elevation of serum angiotensin-converting enzyme in psoriasis are reported in the literature. In order to verify whether this abnormality exists in Iranian patients, we performed this study. Method: Serum angiotensin-converting enzyme level was measured in 40 psoriatics. According to clinical forms of psoriasis, patients were further divided into three groups: common plaque type (n=24), pustular psoriasis (n=10) and erythrodermic psoriasis (n=6). Results: Serum angiotensin-converting enzyme shows some increase in patients with psoriasis; the greatest increase in serum angiotensinconverting enzyme level was observed in patients with erythrodermic psoriasis. Conclusion: Our results suggest that angiotensin-converting enzyme may have a role in the aetiopathogenesis of psoriasis but further studies are warranted to evaluate the possible role of this enzyme in psoriasis.
Azizzadeh Maryam; Malek Mojtaba; Amiri Mehdi; Ghorbani Raheb
Volume 12, Issue 3 , 2009, , Pages 79-81
Abstract
Background: Psoriasis vulgaris is a common chronic and inflammatory disease of skin that its etiology is not completely known. However, it seems that genetic and environmental factors play a role in this disease. In vitro studies show that prolactin as a neurohormone has an etiologic effect on psoriasis. ...
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Background: Psoriasis vulgaris is a common chronic and inflammatory disease of skin that its etiology is not completely known. However, it seems that genetic and environmental factors play a role in this disease. In vitro studies show that prolactin as a neurohormone has an etiologic effect on psoriasis. This study aimed to compare serum prolactin levels in psoriatic patients with control group. Method: Prolactin level in serum was measured with ELISA method in 30 patients with psoriasis vulgaris and in 30 healthy persons as control group, which they had been matched with a view to age and sex. Result: Mean serum prolactin level in psoriatic patients was not significantly higher than control group. However, there was statistically significant relation between severity of disease and serum prolactin levels (r= 0.521, p=0.003). Conclusion: Positive relation between severity of psoriasis vulgaris and serum prolactin levels may suggest that prolactin is an index that shows severity of disease.
Soheila Taheri; Ali Asilian; Gita Faghihi
Volume 12, Issue 2 , 2009, , Pages 36-41
Abstract
Background: Many efforts are made to find new and more effective treatments for psoriasis. Intralesional 5-Fluorouracil (5-FU) +epinephrine is a cheap option which can be administered with long intervals. The effectiveness of Pulse Dye Laser (PDL) on psoriasis has been already assessed. We decided to ...
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Background: Many efforts are made to find new and more effective treatments for psoriasis. Intralesional 5-Fluorouracil (5-FU) +epinephrine is a cheap option which can be administered with long intervals. The effectiveness of Pulse Dye Laser (PDL) on psoriasis has been already assessed. We decided to evaluate the effectiveness of 5-FU+epinephrine and compare it to betamethasone and PDL.Methods: A group of 22 patients with chronic stable plaque psoriasis were included. Three plaques on each patient were treated with 5- FU+epinephrine, PDL and betamethasone, respectively. Psoriasis Severity Index (PSI) scoring was applied to assess each plaque before treatment and in weeks 2, 4, 6, 12, and 24. Photos of each plaque were taken before treatment and at each treatment and follow-up session. They were finally compared and scored by a dermatologist.Results: Decline in mean Psoriasis Severity Index (PSI) in week 6 (2 weeks after treatment) and in week 24 (the last follow-up session) was statistically significant as compared to baseline in all groups. (P<0.001) The highest decline in mean PSI score was in the 5-FU+epinephrine group while the lowest belonged to the PDL group (80% vs. 27%).The mean period of remission in the 5-FU+epinephrine group was significantly longer in comparison to the two other groups. (P<0.001) In photographic evaluation, the best response was observed in the 5- FU+epinephrine group.Conclusion: 5-FU+epinephrine is a cheap option which can provide a rapid response and long remission .With respect to limited effectiveness, short remission and high cost; PDL dose not seem to be a preferred choice in the treatment of psoriasis.
Soheila Nassiri; Farhad Malekzad; Mojdeh Sarlak; Marjan Saeedi; Mehdi Hedayati; Mehdi Qaisari
Volume 12, Issue 2 , 2009, , Pages 56-59
Abstract
Background: The etiology of psoriasis, a chronic inflammatory skin disease, has not been elucidated. However, Oxidant / antioxidant imbalance is suspected.The aim of this study was to evaluate oxidant / antioxidant status in psoriatic patients.Method: forty two psoriatic patients and 42 age and sex matched ...
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Background: The etiology of psoriasis, a chronic inflammatory skin disease, has not been elucidated. However, Oxidant / antioxidant imbalance is suspected.The aim of this study was to evaluate oxidant / antioxidant status in psoriatic patients.Method: forty two psoriatic patients and 42 age and sex matched controls were recruited for this study. Serum total antioxidant capacity (TAC), oxidized light density lipoprotein (Ox-LDL) and malondialdehyde (MDA) levels were determined.Results: A statistically significant increase in the serum level of MDA was found between patients and controls. No significant difference was found in the serum levels of other parameters in the two groups.Conclusion: Our results supported the hypothesis of an imbalance between oxidants and antioxidants in psoriasis and pointed to the probability of an increased risk of cardiovascular diseases in psoriatic patients.
Hallaji Zahra; Ehsani Amir Houshang; Noormohammadopoor Pedram; Mansouri Parham
Volume 12, Issue 2 , 2009, , Pages 60-63
Abstract
Background: Psoriasis is a chronic inflammatory skin disease that is estimated to affect 0.6% to 4.8% of the general population. The optimum number of NB-UVB phototherapy sessions is yet to be determined. The aim of this study was to compare therapeutic effects of NB-UVB in treating chronic plaque type ...
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Background: Psoriasis is a chronic inflammatory skin disease that is estimated to affect 0.6% to 4.8% of the general population. The optimum number of NB-UVB phototherapy sessions is yet to be determined. The aim of this study was to compare therapeutic effects of NB-UVB in treating chronic plaque type psoriasis three times weekly vs. five times weekly. Materials and Methods: This study was designed as a single-blinded randomized controlled trial. Patients with chronic plaque type psoriasis who were candidates for phototherapy were randomized in two groups, one group received NB-UVB three times a week (group A) while the other group received the same treatment five times a week (group B) . Patients’ PASI score was determined before commencing the study and after 12 weeks of treatment. At the end of the study, response rate, PASI score of patients and total dose of UVB per patient were determined. Results: A total of 47 patients were enrolled. Thirty two patients (19 in group A, 13 in group B) completed the study. Total response rate was 71.9% after 12 weeks of treatment (23 out of 32 patients) while nine patients (28.1%) had no response. Response rate was 78.9 % (15 out of 19) in group A Vs. 61.5% (8 out of 13 patients) in group B (p>0.05). Total UVB dose received, treatment sessions, erythema and final PASI score was lower in group A (p>0.05). Conclusion: With similar therapeutic effects, it seems that three times a week regimen may be superior to five times a week for its lower total UVB dose received and higher safety profile.
Mohammad Shahidi–Dadras; Parviz Toossi; Nima Sarrafi–Rad; Reza Mahmoud Robati; Marjan Saeedi; Sima Kavand
Volume 12, Issue 1 , 2009, , Pages 1-3
Abstract
Background: The aggravating role of Staphylococcus aureus is well known in atopic dermatitis but has not yet been proven in psoriasis. The role of Staphylococcus aureus superantigens is emphasized in the initiation, maintenance and complications of psoriasis. We investigated the frequency of nasal, axillary, ...
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Background: The aggravating role of Staphylococcus aureus is well known in atopic dermatitis but has not yet been proven in psoriasis. The role of Staphylococcus aureus superantigens is emphasized in the initiation, maintenance and complications of psoriasis. We investigated the frequency of nasal, axillary, and perineal carriage of Staphylococcus aureus (SA) in patients with psoriasis and its possible influence on the severity of the disease. Methods: one hundred patients with the clinical diagnosis of psoriasis participated in the study. Cultures of the bacterial flora were obtained from the right and left axilla and nasal nares and perineum, inoculated on standard bacterial medium (blood agar), and incubated at 37°C degrees for 48 h. Results: one hundred patients with the clinical diagnosis of psoriasis (42% female and 58% male) comprised the study group. Mean age of the patients was 41.1±17.1 years. About 42 % of the patients carried S. aureus; of these, 32 % were from the nose, 13 % from axilla, and 11% from the perineum. Three patients were carriers in all 3 sites. There was no significant difference in the severity of the disease between the carriers and non-carriers measured by the psoriasis area and severity index (PASI) score. Conclusions: According to our findings, S.aureus carriage in psoriasis had no significant influence on disease severity. It might be relevant for a subgroup of patients only when superantigen productions are found.
Malekzad Farhad; Qeisari Mehdi; Nasiri Soheila; Rahmati-Roudsari Mohammad; Saeedi Marjan; Sarlak Mojdeh
Volume 12, Issue 1 , 2009, , Pages 9-12
Abstract
Background: An elevated homocysteine level is an independent risk factor for cardiovascular disorders. Psoriatic patients have an increased risk of cardiovascular diseases; In addition, hyperhomocysteinemia is a complication of methotrexate treatment. We undertook a study to evaluate the plasma levels ...
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Background: An elevated homocysteine level is an independent risk factor for cardiovascular disorders. Psoriatic patients have an increased risk of cardiovascular diseases; In addition, hyperhomocysteinemia is a complication of methotrexate treatment. We undertook a study to evaluate the plasma levels of homocysteine, vitamin B12 and folate in patients with psoriasis before and after short-term low-dose methotrexate treatment. Methods: Twenty six patients with psoriasis were recruited. The plasma levels of homocysteine, vitamin B12 and folate were evaluated before and 8 weeks after methotrexate therapy (in the peak of methotrexate effect). Results: No significant difference was found between the plasma profile of homocysteine, vitamin B12 and folate before and after methotrexate treatment. Conclusion: In the short-term treatment of psoriasis, methotrexate does not increase homocysteine level.
C.Geilen Christoph
Volume 11, Issue 4 , 2008, , Pages 159-167
Abstract
Psoriasis is a chronic, genetically determined skin disease. A variety of biochemical and molecular biological alterations have been identified, but the pathogenesis of psoriasis is still not clear. For patients with mild to moderate psoriasis, topical therapies are generally used. However, approximately ...
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Psoriasis is a chronic, genetically determined skin disease. A variety of biochemical and molecular biological alterations have been identified, but the pathogenesis of psoriasis is still not clear. For patients with mild to moderate psoriasis, topical therapies are generally used. However, approximately one-third of the patients have a moderate to severe psoriasis and need a systemic therapy. Beside well known therapeutical approach
Reza Yaghoobi; Seyyed Arash Abtahian
Volume 10, Suppl.2 , 2007, , Pages 5-5
Abstract
Psoriasis is quite common in childhood, although congenital psoriasis is very rare. Here, we report a 2-year-old girl with typical linear psoriasis associated with bilateral hypopigmentation of breasts which has been present since birth.
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Psoriasis is quite common in childhood, although congenital psoriasis is very rare. Here, we report a 2-year-old girl with typical linear psoriasis associated with bilateral hypopigmentation of breasts which has been present since birth.
Javidi Zari; Tayyebi-Maybodie Naser; Taheri Ahmad Reza; Nahidi Yalda
Volume 10, Issue 4 , 2007, , Pages 309-315
Abstract
Background and aim: Psoriasis is a dermatologic disease which not only involves the patient physically, but also affects patient's quality of life. Due to its life time duration and psychologic burden, we decided to evaluate patient's quality of life using psoriasis disability index (PDI). Materials ...
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Background and aim: Psoriasis is a dermatologic disease which not only involves the patient physically, but also affects patient's quality of life. Due to its life time duration and psychologic burden, we decided to evaluate patient's quality of life using psoriasis disability index (PDI). Materials and methods: From August 2006 till March 2007, 80 patients referring to Imam-Reza dermatology clinic completed the PDI questionnaire and a demographic questionnaire. Collected data were analyzed by t-test, one way ANOVA tests using SPSS software. Results: 46.2% of patients were male and 53.8% female. The mean age of patients was 40.2 years. 10% had positive family history of psoriasis. 47.5% had a history of hospitalization. 41.3% had articular and 53.8% had nail involvement. Mean morbidity duration was 12.6 years and mean PDI score was 17.4±10 (maximum and minimum scores: 37 and 1 respectively). There was significant difference in mean PDI score in groups considering age, sex, education, location, duration and extent of disease, hospitalization history, nail involvement and type of treatment. Most disability was seen in the treatment field (both sexes) and occupation /school (men) and least disability was seen in individual relationships.Discussion: Psoriasis can reduce the patient's quality of life and satisfaction severely. Therefore supportive strategies can improve their quality of life.
Pezeshkpour Fakhro-Zaman; Layegh Pouran; Nahidi Yalda; Layegh Parvaneh
Volume 10, Issue 3 , 2007, , Pages 245-251
Abstract
Psoriasis is a chronic inflammatory proliferative disorder of the skin that appears in many different forms and affect different parts of the body including the nails and joints. It may affect the quality of life by causing psychosocial stress. Psoriatic arthritis is a seronegative spondyloarthropathy ...
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Psoriasis is a chronic inflammatory proliferative disorder of the skin that appears in many different forms and affect different parts of the body including the nails and joints. It may affect the quality of life by causing psychosocial stress. Psoriatic arthritis is a seronegative spondyloarthropathy with involvement of axial and peripheral joints. Involvement of temporomo andibular joint is also a rare presentation of psoriatic arthritis . In this article we report a rare case of bilateral temporomandibular joint ankylosis secondary to psoriasis in a 50-year-old woman .
Esmaili Nafiseh; Hallaji Zahra; Ehsani Amirhoushang; Tork Ali Naser; Robati RezaMahmood; Toosi Siavash; Zahrian Fatemeh; Maarefat Afsaneh
Volume 10, Issue 2 , 2007, , Pages 100-104
Abstract
Background and aim: Psoriasis is one of the most common inflammatory skin disorders with a genetic background. Several treatment modalities have been used, including systemic and bath PUVA. The aim of this study was to evaluate the efficacy of systemic and bath PUVA in the treatment of psoriasis in Razi ...
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Background and aim: Psoriasis is one of the most common inflammatory skin disorders with a genetic background. Several treatment modalities have been used, including systemic and bath PUVA. The aim of this study was to evaluate the efficacy of systemic and bath PUVA in the treatment of psoriasis in Razi Hospital.Materials and methods: This retrospective database study was done in Razi Hospital and the records of 390 psoriatic patients referred to phototherapy unit in 1999-2003 were studied. One hundred and forty nine patients were treated with systemic and 238 patients with bath PUVA.Results: The most common form of psoriasis was the plaque type and the majority of patients were male. Complete remission of disease was achieved in 20.1% of systemic PUVA and 17.2% of bath PUVA patients, usually after 20-29 sessions of phototherapy. The mean cumulative UVA dose for complete remission was 233.46 and 108.79 J/cm2 in systemic and bath PUVA groups, respectively. Relapse occurred in 33.3% and 17.07% of patients achieving complete remission in systemic and bath PUVA groups, respectively. Erythema was the most common side effect in both groups.Conclusion: Both systemic and bath PUVA are efficacious in the treatment of psoriasis. The total UVA dose needed for complete clearance was higher in systemic PUVA and relapse occurred more frequently in this group.
Ghaninejad Hayedeh; Esmaili Nafiseh; Ghiasi Maryam
Volume 10, Issue 2 , 2007, , Pages 105-110
Abstract
Background and aim: Psoriasis is a chronic inflammatory dermatosis that affects 0.6% to 4.8% of the population. Phototherapy is commonly used in the treatment of this disease. According to the results of previous studies that showed difference in minimal erythema dose between different body sites, it ...
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Background and aim: Psoriasis is a chronic inflammatory dermatosis that affects 0.6% to 4.8% of the population. Phototherapy is commonly used in the treatment of this disease. According to the results of previous studies that showed difference in minimal erythema dose between different body sites, it seems that the responses of psoriatic lesions are also different in various body sites. Our objective was to compare the response of psoriatic lesions to phototherapy in various body sites.Materials and methods: Forty patients with generalized chronic plaque-type psoriasis were enrolled in this study. All patients were examined prior and during phototherapy course every 10 sessions. In each patient time of clearance of psoriatic lesions at trunk, upper and lower extremities were recorded separately.Results: At the end of phototherapy course the lesions of the trunk were cleared completely in 32 patients, and remained partially in 8 patients. The lesions of the upper limbs were cleared completely in 37 patients, and remained partially in 3 patients. The lesions of the lower limbs were cleared completely in 22 patients, and remained partially in 16 patients. Incomplete responses were significantly higher on the lower limbs than the trunk and upper limbs.Conclusion: Therapeutic response of psoriatic lesions to phototherapy is lower on the lower limbsthan the trunk and upper limbs.
Nasiri Soheila; Sedigha Afshin; Farshi Hamideh Moravej; Nabai Leyla; Ebrahimzadeh Simin
Volume 10, Issue 2 , 2007, , Pages 130-134
Abstract
Background and aim: Psoriasis is a common chronic inflammatory and proliferative disease that genetic and environmental factors have a role in its pathogenesis and duration. The objective of this study was to compare the levels of vitamin A and E in the serum of psoriasis patients and control group.Materials ...
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Background and aim: Psoriasis is a common chronic inflammatory and proliferative disease that genetic and environmental factors have a role in its pathogenesis and duration. The objective of this study was to compare the levels of vitamin A and E in the serum of psoriasis patients and control group.Materials and methods: We evaluated 30 psoriasis patients and 30 healthy persons. Vitamin A and E levels were detected with the use of HPLC method. P value less than 0.05 (P<0.05) was considered as significant.Results: Demographic features were matched between groups. Vitamin A level was 1.09×0.27 in control group and 1.08×0.36 in patient group which did not have a meaningful statistical difference (p=0.91). Vitamin E level was 15.52×8.36 in control group and 9.02×5.41 in patient group and the difference was statistically significant (p=0.001). Comparing vitamin A and E levels according to disease severity showed no statistically significant difference.Conclusion: Our results show that vitamin E level in psoriasis patients is lower than healthy group that were matched by age and gender; although vitamin A level was not different between patient and control groups.
A Vali; A Asilian; E Khalesi; L Khodami; MA Shah Talebi
Volume 8, Issue 6 , 2006, , Pages 462-465
Abstract
Background and aim: Psoriasis is one of the most common papulosquamous diseases that often requires long-term maintenance therapy. Long-term use of topical corticosteroids on the face and intertriginous areas will increase the risk of steroids side effects such as striae and atrophy development. A safe, ...
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Background and aim: Psoriasis is one of the most common papulosquamous diseases that often requires long-term maintenance therapy. Long-term use of topical corticosteroids on the face and intertriginous areas will increase the risk of steroids side effects such as striae and atrophy development. A safe, effective and inexpensive modality in topical therapy of inverse psoriasis is required. adrenergic antagonists has been reported to exacerbate existing plaque psoriasis because of increasing concentration of intracellular cAMP. On the other hand, caffeine is a methylxanthin that inhibits phosphodiesterase enzyme and results in a higher concentration of intracellular cAMP. We evaluated the efficacy of topical caffeine 10% in the treatment of psoriasis.Materials and Methods: This randomized, double blind, controlled clinical trial was performed on 39 patients with typical lesions of psoriasis vulgaris who referred to dermatology clinics of Isfahan University of Medical Sciences from December 2002 to July 2003. These patients were randomized in two groups and treated by topical application of drug or placebo, three times per day. The patients were seen in two-week intervals for 8 weeks, and their PASI score was assessed in each visit.Results: The decrease of PASI score after 2,4,6 and 8 weeks compared to the first visit in caffeine treated group were 23%, 41%, 54%, and 62% and in placebo treated group were 15%, 19%, 25%, and 29% respectively(P<0.05).Conclusion: Topical caffeine may be an effective, safe and inexpensive therapy in psoriasis but its onset of action is late.