Yalda Nahidi; Naser Tayyebi Meibodi; Farahnaz Abdolhosseinzadeh; Mostafa Izanlu; Sima Davoodi
Abstract
Background: Psoriasis is a chronic inflammatory skin disease with extensive systemic effects. The role of sex hormones in the pathogenesis of psoriasis remains unknown. Therefore, in this study, the level of sex hormones in male chronic plaque psoriasis patients was evaluated.Methods: This study was ...
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Background: Psoriasis is a chronic inflammatory skin disease with extensive systemic effects. The role of sex hormones in the pathogenesis of psoriasis remains unknown. Therefore, in this study, the level of sex hormones in male chronic plaque psoriasis patients was evaluated.Methods: This study was descriptive-analytic of the cross-sectional type, done with a total population of 60, including 30 patients with chronic plaque psoriasis and 30 healthy subjects in the control group. Serum levels of testosterone, estradiol, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured in patients and the control group who did not have psoriasis. The two groups were matched based on the grouped matching technique. The two groups were matched for age (34 ± 9 years) and BMI (30 ± 3 kg/m2), and the effects of these two variables on hormonal levels were eliminated. According to the results of the Kolmogorov-Smirnov test, the data had a normal distribution. The independent t-test and Pearson correlation coefficient were used for data analysis. A P-value less than 0.05 was considered significant.Results: The levels of LH and FSH were significantly higher in the patient group than in the healthy group (P = 0.01 and P < 0.001, respectively). Testosterone and estradiol serum levels were lower in the patient group than in the healthy group (P < 0.001).Conclusion: Our study suggests that male patients with chronic plaque psoriasis have higher levels of LH and FSH and lower levels of testosterone and estradiol than the general male population.
Tehranchinia Zohreh; Niroomand Mahtab; Kazeminejad Armaghan; Ghahari Mohammad Jafar; Radvar Siamak Esmaeili; Sadat-Amini Seyed Hadi; Younespour Shima; Partovi-Kia Masoud
Volume 17, Issue 2 , 2014, , Pages 43-48
Abstract
Background: Leptin, a 16-KDa peptide hormone secreted from theadipose tissue, plays an important role in the regulation of energyintake and expenditure and body weight regulation; furthermore,it has a regulatory function on the reproductive system. The aimof this study was to assess the relationship ...
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Background: Leptin, a 16-KDa peptide hormone secreted from theadipose tissue, plays an important role in the regulation of energyintake and expenditure and body weight regulation; furthermore,it has a regulatory function on the reproductive system. The aimof this study was to assess the relationship between serum leptinlevels and sex hormones in psoriatic patients and control groupand to determine the serum levels of leptin and sex hormones inpatients and their association with disease severity.Method: This cross-sectional study included 43 male patientswith psoriasis and 42 age- and sex- matched healthy controls. Wemeasured serum levels of leptin, sex hormone-binding globulin(SHBG), luteinizing hormone (LH), follicle stimulating hormone(FSH), prolactin, and total testosterone in both groups.Result: Psoriatic patients had si
H Seirafi; M Nakhjavani; F Farnaghi; AH Ehsani; P Hashemi; M Ghiasi; A Moosavi
Volume 9, Issue 2 , 2006, , Pages 150-153
Abstract
Background and aim: Acne is a chronic inflammatory disease of the pilosebaceous units. Its etiology is unknown. However, several studies have shown that some endocrinologic factors are involved in acne pathogenesis. The aim of this study was to assess some endocrionlogic indices in male patients with ...
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Background and aim: Acne is a chronic inflammatory disease of the pilosebaceous units. Its etiology is unknown. However, several studies have shown that some endocrinologic factors are involved in acne pathogenesis. The aim of this study was to assess some endocrionlogic indices in male patients with acne vulgaris and comparing them with normal controls.Materials and Methods: In this case-control study, 40 male patients with acne referred to Razi hospital during the first 9 months of 1382, and 20 age-matched healthy subjects were selected. Plasma level of insulin, fasting blood sugar (FBS), free testosterone and sex hormone binding globulin (SHBG) were determined and compared between the groups.Results: The mean FBS level was 89.8±13.3 mg/dl in patients with acne and 91.1±16.3 in controls (P=0.017). The mean free testosterone level in cases and controls were 24.8±12.01 and 21.4±10.8 nmol/L, respectively (P=0.029).Conclusion: In this study, the testosterone level in patients with acne was higher and the FBS level was lower than controls. It is recommended that these indices be taken into consideration in male patients with acne.
