Effects of oral consumption of Kombucha tea on mast cells of skin wounds of rats
M
Bayat
author
SN
Razavi
author
A
Hosseini
author
text
article
2001
eng
Background: Positive effects of Kombucha tea (An old folkloric drink of Asian people) on wound healing process have been observed. Objective: To study its effects on the number of mast cells of wound bed. Materials and Methods: The study design was experimental. 42 male adult rats were randomly divided into control and experimental groups. Each group was divided into 3 subgroups. The time of study of first subgroups were 4 days (Represents inflammation phase of wound healing process), of second subgroups were 7 days (Proliferation phase) and of third subgroups were 15 days (Remodeling phase) after wounding. Both groups drank Kombucha tea for 30 days. Then under general anesthesia and sterile conditions, a full thickness wound was made on the dorsum of all rats. The wounding day was considered as day zero. Rats of experimental group drank Kombucha tea after surgery until they were killed by ether at the end of above-mentioned durations. Samples were obtained from rats and prepared for light microscopical study and stained with 1% watery solution of toluidine blue. Mast cells and its grades (According to it’s degranulations) were counted. Data were analyzed by students t test method. Results: Main results were: 1) Total number of most cells of experimental group decreased from 7th day toward 15th day and on 15th day, the difference with control group was significant (P<0.01); 2) In most cases the numbers of mast cells of experimental group were lower than control group and the difference were significant for the 4th day grade 1, 15th day grade 2 (P<0.05) and total number of grades 2 and 3 (P<0.01). Conclusion: Daily consumption of Kombucha tea by rats caused a decreased number of mast cells during skin wound healing and the difference with control group at remodeling phase was significant.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
4
v.
2
no.
2001
3
8
https://www.iranjd.ir/article_98417_a32465b20c4fafe66a9dd4a072a5e069.pdf
Treatment of severe axillary Hyperhidrosis with Botulinum toxin A
R
Salmanpour
author
MJ
Rahmanian
author
text
article
2001
eng
Background: Severe axillary hyperhidrosis causes considerable emotional stress to individuals affected with this condition. Existing topical and surgical therapies are either ineffective or associated with unacceptable morbidity and sequelae. Objective: In this study we attempted to determine the effect of botulinum toxin A (Dysport) in the treatment of axillary hyperhidrosis. Patients and Methods: After visualization of hyperhidrosis using the iodine-starch test, ten patients with axillary hyperhidrosis underwent intradermal injection with 125 units of Dysport in the axillary skin bilaterally. Patients were observed for 7 months after treatment. Results: The treatment was well tolerated without side effects. All patients experienced relatively complete anhidrosis of the axillary skin after about one week for periods lasting from 4 to 7 months. Conclusion: Botulinum-A toxin may offer a fast, safe, and highly effective therapeutic option for severe hyperhidrosis.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
4
v.
2
no.
2001
9
12
https://www.iranjd.ir/article_98418_ad1bae187e9ea78f27dca57c9a8d4fa1.pdf
Association of ABO & Rh blood groups with Vitiligo
M
Valikhani
author
L
Vosooghian
author
text
article
2001
eng
Background: Vitiligo is a common disease. Its etiology is not known, but 30% of patients have a positive family history. Studies have been done on the influence of ABO and Rh blood groups on susceptibility to some diseases. Objective: The purpose of this case-control study was to evaluate the association of ABO and Rh blood groups with vitiligo. Patients and Methods: This study was performed on 200 vitiligo patients referred to skin clinics of Razi Hospital. The blood groups of patients were determined and compared with 200 control subjects and the general blood group distribution in Iran (Published by Iran Blood Transfer Organization). Results: There was no specific association established between vitiligo and ABO and Rh blood groups. Blood group B showed the most difference but still it was not significant (P>0.05). Conclusion: There was no association with the ABO and Rh blood group in vitiligo patients.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
4
v.
2
no.
2001
13
16
https://www.iranjd.ir/article_98420_515ead1a9feaf3ceba43428276b80259.pdf
Thyroid disorders in patients with Vitiligo
S
Family
author
text
article
2001
eng
Background: Vitiligo is a pigmentary disorder of the skin, which has been reported in association with thyroid disorders. Objective: The aim of this study was to assess thyroid disorders in vitiligo patients. Patients and Methods: In this case-control study, thyroid function tests were evaluated in seventy patients with vitiligo and compared with a control group. Results: Nine of seventy patients with vitiligo (12.9%) and one of controls (1.4%) had abnormal thyroid function tests. Conclusion: Thyroid disorders are more common in vitiligo.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
4
v.
2
no.
2001
17
20
https://www.iranjd.ir/article_98421_eeeb4bb40bc74dac4b4b235d16858cee.pdf
Combination chemotherapy with Methotrexate, Fluorouracil and Leucovorin in advanced Mycosis Fungoides
M
Shahidi Dadras
author
L
Ataei
author
text
article
2001
eng
Background: Mycosis fungoides (MF) is a cutaneous T cell lymphoma. There are only palliative treatments in advanced stages with no cure. Most chemotherapy regimens have temporary effects with various side effects. Objective: The objective of this study was to assess the efficacy of a new chemotherapy regimens in advanced stages of MF. This regimens takes advantage of synergistic effect of methotrexate and fluorouracil and also uses leucovorin to reduce side effects of methotrexate. Patients and Methods: Five patients with advanced stages of MF (Stage IIB and higher) were treated with several courses of this chemotherapy regimens in a quasi experimental study. Results: Four patients responded partially one responded completely to this regimen but all of them relapsed after tapering the treatment. All of them tolerated the drugs well and no serious side effects were observed. Tumoral lesions showed better response. Conclusion: Although this chemotherapy regimen, similar to other regimens, only had temporary and palliative effects, it was tolerated well without serious side effects.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
4
v.
2
no.
2001
21
25
https://www.iranjd.ir/article_98422_46292f657048ffcc9f5b3fa979915ee8.pdf
Epidermal nevus syndrome: Report of a giant linear epidermal nevus
A
Asilian
author
M
Omrani Fard
author
Adabi
M
author
text
article
2001
eng
Linear epidermal nevi frequently follow the lines of Blaschko and may be confused with the verrucous stage of incontinentia pigmenti. Inflammatory epidermal nevus appears as a line array of pink to red papules usually on the lower limb (Buttock and hip) clinically resembling psoriasis or eczematous dermatitis. But inflammatory epidermal nevus has distinct histopathologic features. We report a case of a 12-year-old Iranian girl who had a huge verrucous lesion on left lower limb since age of 4 years. Bone age of the patient was 6 years and her left lower limb was 6 centimeters longer than right side. Her lesion was excised in several sessions and grafted but showed recurrence.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
4
v.
2
no.
2001
26
28
https://www.iranjd.ir/article_98423_0d5ea98b230d0876aef6ef0c18556a42.pdf
Congenital Atrichia: A case report
M
Farshchian
author
K
Nabizadeh
author
text
article
2001
eng
We report a twenty-seven-year-old man with the absence of hair on the scalp and eyebrows, which began shortly after his birth. One of his brothers had this problem too. Considering clinical signs and skin biopsy report of the patient, a diagnosis of congenital atrichia was made. The latest findings on the genetic of this disease will be reviewed.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
4
v.
2
no.
2001
29
32
https://www.iranjd.ir/article_98419_172e4f9605bf959b9a7be260a5df2987.pdf
Pyoderma Gangrenosum and Multiple Myeloma: A case report
M
Nazerian
author
text
article
2001
eng
A 79-year-old female came to skin clinic with an ulcer, 15×20 cm, on her left shin. The laboratory report and both the skin and bone marrow biopsies reports, showed pyoderma gangrenosum associated with multiple myeloma. The patient was referred to hematology clinic for treatment. Multiple myeloma has rarely been associated with pyoderma gangrenosum. Multiple myeloma should be investigated in patients with paraproteinemia and pyoderma gangrenosum.
Iranian Journal of Dermatology
Iranian Society of Dermatology
2717-0721
4
v.
2
no.
2001
33
36
https://www.iranjd.ir/article_98424_a8af0a09adc912208302243f237efc79.pdf