@article { author = {Mirshams Shahshahani, Mostafa and Razzaghi, Mahmood and Ehsani, Amir Houshang and Normohamadpour, Pedram and Naraghi, Zahra and Kamyab, Kambiz and Sabouri Rad, Sara}, title = {Incidence of incomplete excision in surgically treated basal cell carcinomas and identification of the related risk factors}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {1-5}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background: Surgery is the most frequent treatment modality for basal cell carcinoma but in spite of its high cure rate, the frequency of incomplete excision varies widely (0.7-50%) among dermatologic centers. Our case series was designed to determine the frequency of incompletely excised basal cell carcinoma and the related risk factors. Methods: A total of 1424 basal cell carcinoma (1040 patients) lesions which were excised in Razi Dermatology Hospital of Tehran from 2006 to 2008 were evaluated in this case series and their findings were analyzed with SPSS software. Results: Incidence of incomplete excision was 12% and involvement of the deep margin was observed in 54% of these lesions. Factors related to incomplete excision were infiltrative, morpheic and micronodular subtypes, lesions larger than 20 mm, those repaired by skin grafts and those that received local anesthesia. There was no statistically significant difference in age, sex, site of lesions and childhood history of radiotherapy for tinea capitis. Conclusion: Recognizing the risk factors related to incomplete excision of BCCs would help us consider a wider excision margin for high risk tumors.}, keywords = {Basal cell carcinoma,Incomplete excision,Surgery,tumor margin}, url = {https://www.iranjd.ir/article_98133.html}, eprint = {https://www.iranjd.ir/article_98133_b6232f1535a3e0395dafb30953a1af6c.pdf} } @article { author = {Akhyani, Maryam and Seirafi, Hasan and Hallaji, Zahra and Kiani, Pardis and Sabouri rad, Sara and Ahrar Mohammad, Hosein}, title = {Correlation between the severity of alopecia areata and its risk factors}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {6-11}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background: Alopecia Areata (AA) is a recurrent non-scarring type of hair loss that can affect any hair-bearing area. Prognosis of AA is unpredictable and most patients experience more than one episode of hair loss. The purpose of this study was to investigate the relationship between the severity of AA with respect to age of onset, nail involvement, family history, number of recurrences and duration of the disease. Methods: A total of 239 consecutive patients with AA who were visited in our dermatology clinic from June 2009 to November 2009 were included in this study. The extent of scalp involvement, age of onset, nail involvement, family history, number of recurrences and duration of AA were recorded. Results: Two hundred and thirty nine (239) patients with AA including 141 males and 98 females entered our analysis (male: female ratio = 1.43:1). The age of the patients at the onset of the disease had a wide range from 1 to 60 years (mean ± SD = 21.51 ± 5.4). Two hundred and twelve patients (88.7%) had their first episode of AA before the age of 40 years. Duration of the AA varied from 1 month to 31 years. Ninety six (40.2%) patients experienced only one episode and 25 patients (10.5%) had more than 4 episode of alopecia. Nail changes was reported in 34 patients (14.2%). Forty five patients (18.8%) had a positive family history of alopecia areata. A personal history of atopy and autoimmune diseases was seen in 23 (9.6%) and 27 (11.3%) patients, respectively. The relationship between extensive AA and age of onset, duration, nail changes and positive family history was confirmed (p 0.05). Conclusion: AA occurred at a comparatively younger age. There was a correlation between extensive alopecia areata and age of onset, duration, nail changes, and positive family history as prognostic factors. There were no relationships between the severity of AA and sex, history of atopy and autoimmune diseases.}, keywords = {Alopecia areata,hair loss,risk factors,Prognostic factors}, url = {https://www.iranjd.ir/article_98134.html}, eprint = {https://www.iranjd.ir/article_98134_edc0045b5c6246d88bd30720caf9316e.pdf} } @article { author = {Ghalamkarpour, Fariba and Robati, Reza and Ghasir, Ghadeh and Saeedi, Mohammad and Mohtasham, Nahid}, title = {The 308-nm xenon chloride excimer laser in combination with topical calcipotriol in the treatment of vitiligo}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {12-15}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background: Treatment of vitiligo remains an attractive topic and several therapies with varying degrees of success have been used. The aim of this study was to find out whether the combination of topical calcipotriol and excimer laser increases the efficacy of therapy compared to excimer laser alone. Methods: Twenty eight patients in two groups were treated with 308nm excimer laser alone (14 patients) and the combination of excimer laser–calcipotriol (14 patients). After 16 sessions, response rate, side-effects and compliance were assessed. Results: Repigmentation rate more than 50% was significantly higher in the laser- calcipotriol group. No differences were seen in complication rate between the two groups. Conclusion: Combination of calcipotriol and 308nm excimer laser might enhance the response rate without increasing treatment complications.}, keywords = {excimer,calcipotriol,Laser,phototherapy,NBUVB,Vitiligo}, url = {https://www.iranjd.ir/article_98135.html}, eprint = {https://www.iranjd.ir/article_98135_3050dca50508a3616f39bd34dcbc8ddb.pdf} } @article { author = {Torkamani, Niloufar and Kamali Sarvestani, Eskandar and Naseri, Mahsa}, title = {Investigation of serum APRIL and BAFF levels in pemphigus vulgaris patients in Southern Iran}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {16-19}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background: Pemphigus vulgaris, the most common form of pemphigus, is due to the production of auto-antibodies directed against adhesion molecules (desmoglein 1 and 3) that belong to the cadherin family. B cell-activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) may play a significant role in autoimmune diseases such as pemphigus vulgaris. Only a few studies have been done on the level of APRIL and BAFF in PV patients but none have investigated both levels; therefore, determination of both proliferation inducing ligands (BAFF and APRIL) in pemphigus vulgaris is of significant importance and was considered as the goal of the present study. Methods: This analysis included 22 patients with PV and 22 sex and age matched healthy controls. None of the patients had previously been treated with corticosteroids or any immunosuppressive drugs in the previous three months. The BAFF and APRIL levels were evaluated in patient and control groups by use of ELISA method. Results: Comparison of the serum levels of BAFF and APRIL between patients and controls was done using Mann-Whitney U test. The BAFF levels in our 22 patients and control sera were undetectable. On the other hand, concentrations of APRIL in 22 cases were 2.09+/-4.94 and 0.85+/-2.01 in the control group. Conclusion: BAFF levels were undetectable in cases and the difference in APRIL levels between patient and control groups was not significant (p=0.28). So, it can be concluded that although BAFF and APRIL may play a role in autoimmune diseases, their role in pemphigus vulgaris is doubtable.}, keywords = {Pemphigus vulgaris,autoimmune bullous disease,B- cell activation factor,Tumor Necrosis Factor,April,proliferation-inducing ligand}, url = {https://www.iranjd.ir/article_98136.html}, eprint = {https://www.iranjd.ir/article_98136_01ef2b18d527e8dfd6ff42c7d32237fd.pdf} } @article { author = {Mapar, Mohammad Ali and Hashemzade, Sarah and Yaghoobi, Reza}, title = {A comparison between systemic psoralen plus ultraviolet A therapy and topical clobetasol in the treatment of vitiligo}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {20-24}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background: Topical corticosteroids and oral psoralen plus ultraviolet A radiation (PUVA therapy) are two common treatment methods for vitiligo. The aim of this study was to compare the efficacy, complications and patterns of repigmentation of these two methods. Methods: This prospective randomized clinical trial was conducted from July 2007 to October 2008. Patients with disseminated vitiligo were divided into two groups. PUVA therapy was administered in one group and topical clobetasol was used in the other group. Results were recorded in 4 categories and therapeutic findings and complications were compared after 24 weeks. Results: Among 37 participants in the PUVA therapy group, 18 (48.6%) patients achieved marked and 14 (37.8%) patients showed good repigmentation. Similarly, among 35 participants in the clobetasol group, 6 (17.1%) patients showed marked and 8 (22.8%) patients showed good repigmentation. treatment complications were observed in 16.2% of the participants in PUVA group and 28.6% of the participants in clobetasol group. The patterns of repigmentation were different in the two groups. Conclusion: PUVA showed better therapeutic effects, and did not cause significant complications. Therefore, it could be used as one of the first line medications in the treatment of vitiligo.}, keywords = {clobetasol,phototherapy,PUVA,Vitiligo}, url = {https://www.iranjd.ir/article_98137.html}, eprint = {https://www.iranjd.ir/article_98137_cba643a9c4a84d75ed756fbf10907d06.pdf} } @article { author = {Radmanesh, Mohammad and Sharifi, Mehrana and Shafiei, Sedigheh}, title = {Lichen simplex chronicus, neurotic excoriation and nodular prurigo and their correlation with atopy: A case-control study}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {25-28}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background: Lichen simplex chronicus (LSC), nodular prurigo (NP), and neurotic excoriation (NE) are considered as psychogenic pruritus disorders. Atopic dermatitis (AD) is also classified by some as a psychocutaneous disorder to point out the influence of psychologic factors in its recurrence, persistence and precipitation. AD and psychogenic pruritus share many common features including immunohistology, clinical course and their psychiatry. The aim of this assay was to study the correlation between psychogenic pruritic disorders and atopy.Methods: Ninty-two patients with psychogenic pruritus, including 57 cases of LSC, 27 cases of NE and 8 cases of NP, were referred to us within a period of 18 months. The patients were studied in our private Dermatology-Psychiatry liaison Clinic in order to find out the correlation of those disorders with atopy. Ninty-two healthy individuals with no apparent dermatologic disoder were selected from the general population as controls. Patients were considered atopic if they had the history of dermatitis, asthma or hay fever with the typical age of onset, distribution, seasonal variation, and history of remission and recurrence. Atopy was investigated by physical examination and thorough history by completing a questionnaire containing all reported major and minor criteria in the literature.Results: Forty five out of 92 patients with psychogenic pruritic disorders (48.9%) were atopic which was significant in comparison with the control group (20.6%) (p<0.0001, odd ratio = 3.68 (3.29 – 4.24), and CI = 99%).Conclusion: This study showed that atopic state seemed to be more common in patients with psychogenic pruritic disorders.}, keywords = {atopy,Atopic Dermatitis,psychogenic pruritus,Lichen simplex chronicus,neurotic excoriation,nodular prurigo}, url = {https://www.iranjd.ir/article_98138.html}, eprint = {https://www.iranjd.ir/article_98138_21a17691900d7e49e10a8122d6b4cb53.pdf} } @article { author = {Nisa, Nuzhatun and Qazi, Masood and Shah, Iffat}, title = {Pyoderma gangrenosum in a patient with antiphospholipid antibody negative systemic lupus erythematosus: A case report}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {29-31}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {In any description of leg ulcers in systemic lupus erythematosus (SLE), pyoderma gangrenosum (PG) earns a mention at least for its being quite rare in such patients. The causative role of aPL (antiphospholipid antibody) in dermatological manifestations of SLE is undermined by the occurrence of PG in aPL negative SLE patients. To the best of our knowledge, there are only two reports of PG in aPL negative SLE patients; in one, PG preceded the diagnosis of SLE by several years while the other was associated with the reactivation of the disease in an already diagnosed SLE patient. In view of the rarity of this association, we hereby present another similar case to substantiate the documentation of the association of the entities.}, keywords = {atopy,Atopic Dermatitis,psychogenic pruritus,Lichen simplex chronicus,neurotic excoriation,nodular prurigo}, url = {https://www.iranjd.ir/article_98139.html}, eprint = {https://www.iranjd.ir/article_98139_9c705b48083897a205136b5c618c1268.pdf} } @article { author = {Farshchian, Mahmood and Ghasem, Rahmatpour}, title = {Lichen planus pemphigoides: A case report}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {32-34}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Lichen planus pemphigoides (LPP) is a rare autoimmune blistering disease that is characterized by the development of vesico-bullous skin lesions in patients with lichen planus. The histopathology of LPP reveals a sub_epidermal blister with linear deposition of IgG and /or C3 along the dermal_epidermal junction (DEJ) upon direct immunofluorescence (DIF). We hereunder describe a case of lichen planus pemphigoides in a 69-year-old otherwise healthy male who initially presented with typical lesions of lichen planus (LP), predominantly on the lower extremities; then, bullous lesions developed on the normal skin.    }, keywords = {bullous pemphigoid,lichen planus pemphigoides,Lichen Planus,bullous disease,direct immunofluorescence}, url = {https://www.iranjd.ir/article_101388.html}, eprint = {https://www.iranjd.ir/article_101388_c0bf2a377f8fe10217459580574248d0.pdf} } @article { author = {Kamyab, Kambiz and Jamshidi, Samaneh and Ghasemi, Hamed and Seraj, Maryam}, title = {A rare type of reaction to tattoo materials: A granuloma annulare-like reaction}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {35-36}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Granuloma annulare represents a reaction pattern that is recognized as idiopathic in many cases but is attributed to a variety of inciting factors in some cases. In this report, we present a case of granuloma annulare-like pattern reaction to tattoo pigment.}, keywords = {granoluma annulare,tattoo,Side effect,necrobiotic reaction}, url = {https://www.iranjd.ir/article_98140.html}, eprint = {https://www.iranjd.ir/article_98140_35995d0644e4cb14a0ea93abc5264418.pdf} } @article { author = {Shahidi Dadras, Mohammad and Hejazi, Somayeh and Ayatollahi, Azin and Saeedi, Mohammad}, title = {Ulcerative lesions on the extremities with black eschar}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {37-39}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Case: A 47-year-old Iranian man presented with a 3-month history of painful extremities lesions. The lesions began with an erythematous papule that progressively enlarged and ulcerated. His left calf was the first site of involvement. At the time we visited him, there were necrotic painful violaceous skin ulcers with a symmetrical distribution involving lower parts of distal limbs and his left thigh. He had a 10-year history of hypertension and a 5-month history of peritoneal tuberculosis. Recently, he received dialysis due to End Stage Renal Disease (ESRD). He had received medications such as Furosemide, Omeprazol, Isoniazid, Ethambutol, Rifampin and Pyrazinamide from 5 months ago. Physical examination showed a cachectic middle aged man in distress because of severe pain. His abdomen was distended, but no ascitis or organomegaly was detected. The pedal pulse was absent. Large multiple ulcers with surrounding erythema and induration, some with dark eschar, were seen on his calves, thighs and left hand (Figure 1). Some of his toes and two fingers of his left hand were gangrenous. A hand x-ray and a skin biopsy from the newest lesion were obtained. Some soft tissue opacities were seen in the hand x-ray (Figure2).}, keywords = {}, url = {https://www.iranjd.ir/article_98141.html}, eprint = {https://www.iranjd.ir/article_98141_3006c7a5e5dd36c4059ac34f0435f25b.pdf} } @article { author = {Ehsani, Amir Houshang and Normohammadpour, Pedram and Kheirkhah Sabetghadam, Shahrbanoo}, title = {Langerhans cell histiocytosis with bilateral parotiditis}, journal = {Iranian Journal of Dermatology}, volume = {14}, number = {1}, pages = {40-41}, year = {2011}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {.}, keywords = {}, url = {https://www.iranjd.ir/article_98142.html}, eprint = {https://www.iranjd.ir/article_98142_822a4d5501ccdec49dd4d450454d877b.pdf} }