@article { author = {Farhad, Malekzad and Mehdi, Qeisari and Soheila, Nasiri and Mohammad, Rahmati-Roudsari and Marjan, Saeedi and Mojdeh, Sarlak}, title = {Does Short-Term Low-Dose Methotrexate Treatment Affect Homocysteine Blood Level in Patients with Psoriasis?}, journal = {Iranian Journal of Dermatology}, volume = {12}, number = {1}, pages = {9-12}, year = {2009}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background: An elevated homocysteine level is an independent risk factor for cardiovascular disorders. Psoriatic patients have an increased risk of cardiovascular diseases; In addition, hyperhomocysteinemia is a complication of methotrexate treatment. We undertook a study to evaluate the plasma levels of homocysteine, vitamin B12 and folate in patients with psoriasis before and after short-term low-dose methotrexate treatment. Methods: Twenty six patients with psoriasis were recruited. The plasma levels of homocysteine, vitamin B12 and folate were evaluated before and 8 weeks after methotrexate therapy (in the peak of methotrexate effect). Results: No significant difference was found between the plasma profile of homocysteine, vitamin B12 and folate before and after methotrexate treatment. Conclusion: In the short-term treatment of psoriasis, methotrexate does not increase homocysteine level.}, keywords = {homocysteine,methotrexate,Psoriasis}, url = {https://www.iranjd.ir/article_98074.html}, eprint = {https://www.iranjd.ir/article_98074_7b3a4a5e5bfa8f1c8ed45d5eebef26b2.pdf} }