@article { author = {Asilian, A and Omid Ghaemi, MR and Momeni, A and Iraji, F}, title = {Effect of vitamin E and Acitretin combination on decreasing side effects of Acitretin}, journal = {Iranian Journal of Dermatology}, volume = {5}, number = {3}, pages = {22-28}, year = {2002}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background: Acitretin therapy is frequently associated with reversible, dose-related side effects. Recent studies claimed that combining vitamin E with high-dose isotretinoin reduced isotretinoin-induced side effects. Objective: The purpose of this clinical trial study was to determine the effect of a fixed or adjusted dose of vitamin E on the side effects of acitretin. Patients and Methods: Fifty five subjects were randomly assigned to one of the two treatment programs including with acitretin (0.7-1 mg/kg/day) together with either vitamin E (13 IU/kg/day) or alone for 3 months. The incidence of side effects of acitretin in two groups were assessed and compared. Results: The study was completed in thirty-nine patients. Vitamin E did not decreased the incidence of side effects associated with acitretin. Conclusion: Vitamin E did not significantly ameliorate retinoid side affects when combined with 0.7-1 mg/kg of acitretin in treatment of skin disorders.}, keywords = {Retinoid,Vitamin E,acitretin}, url = {https://www.iranjd.ir/article_98449.html}, eprint = {https://www.iranjd.ir/article_98449_54c0e54396586698d1859f31cfce6116.pdf} }