%0 Journal Article %T Does Short-Term Low-Dose Methotrexate Treatment Affect Homocysteine Blood Level in Patients with Psoriasis? %J Iranian Journal of Dermatology %I Iranian Society of Dermatology %Z 2717-0721 %A Farhad, Malekzad %A Mehdi, Qeisari %A Soheila, Nasiri %A Mohammad, Rahmati-Roudsari %A Marjan, Saeedi %A Mojdeh, Sarlak %D 2009 %\ 04/01/2009 %V 12 %N 1 %P 9-12 %! Does Short-Term Low-Dose Methotrexate Treatment Affect Homocysteine Blood Level in Patients with Psoriasis? %K homocysteine %K methotrexate %K Psoriasis %R %X Background: An elevated homocysteine level is an independent risk factor for cardiovascular disorders. Psoriatic patients have an increased risk of cardiovascular diseases; In addition, hyperhomocysteinemia is a complication of methotrexate treatment. We undertook a study to evaluate the plasma levels of homocysteine, vitamin B12 and folate in patients with psoriasis before and after short-term low-dose methotrexate treatment. Methods: Twenty six patients with psoriasis were recruited. The plasma levels of homocysteine, vitamin B12 and folate were evaluated before and 8 weeks after methotrexate therapy (in the peak of methotrexate effect). Results: No significant difference was found between the plasma profile of homocysteine, vitamin B12 and folate before and after methotrexate treatment. Conclusion: In the short-term treatment of psoriasis, methotrexate does not increase homocysteine level. %U https://www.iranjd.ir/article_98074_7b3a4a5e5bfa8f1c8ed45d5eebef26b2.pdf