%0 Journal Article %T Serum leptin levels in psoriatic patients with non-alcoholic fatty liver disease %J Iranian Journal of Dermatology %I Iranian Society of Dermatology %Z 2717-0721 %A Hallaji, Zahra %A Lajevardi, Vahideh %A Abedini, Robabeh %A Soleymani, Amir %A Goodarzi, Azadeh %A Salehi-Taleghani, Mehrnaz %A Beygi, Sara %D 2016 %\ 10/01/2016 %V 19 %N 4 %P 125-130 %! Serum leptin levels in psoriatic patients with non-alcoholic fatty liver disease %K Psoriasis %K non-alcoholic fatty liver %K leptin %R %X Background: The prevalence of non-alcoholic fatty liver disease is higher in patients with psoriasis than in the normal population. Serum leptin levels are higher in patients with psoriasis and in patients with non-alcoholic fatty liver. The purpose of this study was to determine the serum levels of leptin in psoriatic patients with and without non-alcoholic fatty liver.Methods: This cross-sectional study was conducted at Razi Dermatology Hospital, Tehran, Iran in 2013. A total of 50 patients with psoriasis were enrolled in the study. Fatty liver grade was assessed via ultrasonography and serum leptin levels were measured using the ELISA method.Results: Ten patients had normal livers and 40 had fatty livers with different grades. The median serum leptin level was significantly higher in psoriatic patients with fatty liver (11.75ng/mL) in comparison to those without fatty liver (2.80 ng/ml). Moreover, there was a direct correlation between the leptin level and the grade of fatty liver.Conclusion: serum leptin can be elevated in the course of psoriasis and may have a role in the pathogenesis of non-alcoholic fatty liver disease and other metabolic co morbidities in psoriatic patients. %U https://www.iranjd.ir/article_99441_736b8c98e513b3012077ba740076267b.pdf