Iranian Society of Dermatology
Iranian Journal of Dermatology
2717-0721
22
4
2020
01
01
Comparison of COX2 expression in radiation induced basal cell carcinoma and non-radiation induced basal cell carcinoma
123
128
EN
Yalda
Nahidi
0000-0001-8161-6939
Cutaneous Leishmaniasis Research
Center, Mashhad University of
Medical Sciences, Mashhad, Iran
nahidiy@mums.ac.ir
Naser
Tayyebi Meibodi
Cutaneous Leishmaniasis Research
Center, Mashhad University of
Medical Sciences, Mashhad, Iran
tayebin@mums.ac.ir
Amir Hossein
Jafarian
Pathology Department, Ghaem
Hospital, School of Medicine,
Mashhad University of Medical
Sciences, Mashhad, Iran
Habibollah
Esmaily
Health Sciences Research Center,
Department of Biostatistics and
Epidemiology, School of Health,
Mashhad University of Medical
Sciences, Mashhad, Iran
Elham
Pishnamaz
Radiology Department, Birjand
University of Medical Sciences,
Birjand, Iran
10.22034/ijd.2020.104814
<strong>Background:</strong> Radiation-induced basal cell carcinoma (BCC) can be multiple, large, and recurring, which complicates its treatment in some cases. According to reports on the role of cyclooxygenase 2 (COX<sub>2</sub>) inhibitors in the treatment or prevention of non-melanoma skin cancers and considering the fact that COX<sub>2</sub> expression has not been evaluated in radiation-induced basal cell carcinoma, we<br />set out to assess the expression of COX<sub>2</sub> in these lesions.<br /> <strong>Methods:</strong> In this study, COX<sub>2</sub> expression was assessed by immunohistochemistry using anti-COX<sub>2</sub> antibody on paraffinembedded blocks of 86 patients referred to Emam Reza Hospital<br />in Mashhad with BCC diagnosis by pathological examination (43 patients with and 43 without a history of radiotherapy) followed by semi-quantitative evaluation of COX<sub>2</sub>.<br /> <strong>Results:</strong> In our study, COX<sub>2</sub> expression score was significantly higher in patients with a history of radiotherapy than those without radiotherapy (P<0.001). No correlation was found between the<br />intensity and percentage of staining with sex, age, site of lesion, recurrence, and pathology of the tumor.<br /> <strong>Conclusion:</strong> Given the higher expression level of COX<sub>2</sub> in the radiation-induced BCC patients, the use of COX<sub>2</sub> inhibitors in these individuals may be effective in the incidence, recurrence, or treatment of BCC.
Basal cell carcinoma,cyclooxygenase 2,immunohistochemistry,radiotherapy
https://www.iranjd.ir/article_104814.html
https://www.iranjd.ir/article_104814_ae3e4a6b50273a9b6077a9e3d3b69b49.pdf
Iranian Society of Dermatology
Iranian Journal of Dermatology
2717-0721
22
4
2020
01
01
The association of androgenetic alopecia with metabolic syndrome: a case control study on Iranian population
129
132
EN
Ahmad Reza
Taheri
Cutaneous Leishmaniasis Research
Center, Mashhad University of
Medical Sciences, Mashhad, Iran
Mozhgan
Afkhamizadeh
Metabolic Syndrome Research
Center, Department of
Endocrinology, Imam Reza Hospital,
Mashhad University of Medical
Sciences, Mashhad, Iran.
Sara
Sabourirad
Cutaneous Leishmaniasis Research
Center, Mashhad University of
Medical Sciences, Mashhad, Iran
sabourirads@mums.ac.ir
Omid
Hassani
Birjand University of Medical
Sciences, Birjand, Iran.
Somaye
Ghanizadeh
Dermatology Department, Mashhad
University of Medical Sciences,
Mashhad, Iran
somayeghanizadeh@gmail.com
10.22034/ijd.2020.104819
<strong>Background:</strong> Androgenetic alopecia (AGA) is the most prevailing type of progressive hair loss. Thus far, some previous studies have investigated the correlation between AGA and metabolic<br />syndrome (MetS). However, due to the inconsistency of their results, our study aims at evaluating the association between AGA and MetS.<br /><strong>Methods:</strong> Fifty two male patients with grade III-V AGA, based on Ebling’s scale, and 50 control subjects were enrolled in the present study. All participants were evaluated for the presence<br />of Mets based on the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III).<br /><strong>Results:</strong> The prevalence of MetS was 51.3% in AGA group and 17.8% in control group (P=0.003). Among MetS parameters, Systolic blood pressure (P=0.003) and waist circumference (P<0.001)<br />were statistically significant in AGA patients compared to the control group.<br /><strong>Conclusion:</strong> Our study demonstrated that the association between AGA and MetS is of great importance. Therefore, early detection can be beneficial for early intervention to lower the incidence of MetS and further complications.
Alopecia,Metabolic Syndrome,androgens
https://www.iranjd.ir/article_104819.html
https://www.iranjd.ir/article_104819_35c533f6af6591389f83f32ea613ea09.pdf
Iranian Society of Dermatology
Iranian Journal of Dermatology
2717-0721
22
4
2020
01
01
Carotid doppler ultrasound evaluation in patients with lichen planus
133
138
EN
Zeinab
Aryanian
Autoimmune Bullous Diseases Research
Center, Tehran University of Medical
Sciences, Tehran, Iran
z_aryanian@yahoo.com
Hosein
Shahabandaz
Department of Radiology and
Radiotherapy, School of Medicine, Babol
University of Medical Sciences, Babol, Iran
Meysam
Abdollahzadeh Sangrody
Student Research Committee, Babol
University of Medical Sciences, Babol, Iran
Azar
Shirzadian
Department of Dermatology, School of
Medicine, Babol University of Medical
Sciences, Babol, Iran
Soodabeh
Tirgartabari
Clinical Research Development Center,
Shahid Yahyanezhad Hospital, Babol
University of Medical Sciences, Babol, Iran
Ali
Bijani
Department of Statistic and Epidemiology,
School of Medicine, Babol University of
Medical Sciences, Babol, Iran
Shabnam
Fahim
Department of Dermatology, Razi Hospital,
Tehran University of Medical Sciences,
Tehran, Iran
Ifa
Etesami
Department of Dermatology, Razi Hospital,
Tehran University of Medical Sciences,
Tehran, Iran
Arghavan
Azizpour
Autoimmune Bullous Diseases Research
Center, Tehran University of Medical
Sciences, Tehran, Iran
azizpour63@gmail.com
Azadeh
Goodarzi
0000-0002-6913-3210
Department of Dermatology, School of
Medicine, Rasoul Akram Hospital, Iran
University of Medical Sciences, Tehran,
Iran
goodarzi.a@iums.ac.ir
10.22034/ijd.2020.104823
<strong>Background:</strong> Lichen planus is a chronic inflammatory disease associated with an increased risk of subclinical atherosclerosis and cardiovascular diseases. This study aimed to evaluate patients with lichen planus using carotid Doppler ultrasound parameters.<br /><strong>Methods:</strong> Forty patients with lichen planus and 40 controls were included in this study. Common carotid artery intima-media thickness (CIMT) and the number of atherosclerotic plaque were<br />measured and compared to the control group. Total cholesterol, triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured. Leptin level (Pg/ml)<br />was measured using the enzyme-linked immunosorbent assay (ELISA) method (Leptin ELISA kit, Orgenium, Finland).<br /><strong>Results:</strong> Significant difference was found between the groups in terms of CIMT (P=0.005). The median range for blood leptin level, triglyceride, cholesterol, and LDL was higher for lichen planus patients than for controls. We found a significant difference between the severity of LP and CIMT (P=0.035). No statistical difference was found between LP and the number of atherosclerotic plaque.<br /><strong>Conclusions:</strong> Our study suggested that measurement of the mean intima media wall thickness of the common carotid artery could be beneficial as a valuable method for early diagnosis of atherosclerosis in lichen planus.
Lichen Planus,common carotid artery,Doppler ultrasound
https://www.iranjd.ir/article_104823.html
https://www.iranjd.ir/article_104823_9c982e1a24bd55529a7eee1fc8e31b3e.pdf
Iranian Society of Dermatology
Iranian Journal of Dermatology
2717-0721
22
4
2020
01
01
Validity and reliability of Persian version of infants’ dermatitis quality of life index (IDQOL) questionnaire
139
144
EN
Saman
Mohammadi
Department of Dermatology,
Afzalipour Hospital, Kerman
University of Medical Sciences, Iran
Saeedeh
Farajzadeh
Leishmaniasis Research Center,
Kerman University of Medical
Sciences, Iran
Hossein
Safizadeh
Social Determinants of Health
Research Center, Institute for
Futures Studies in Health, Kerman
University of Medical Sciences,
Kerman, Iran
Maryam
Khalili
0000-0003-1866-7092
Department of Dermatology,
Afzalipour Hospital, Kerman
University of Medical Sciences, Iran
maryam_khalili36@yahoo.com
Mahin
Aflatoonian
Department of Dermatology,
Afzalipour Hospital, Kerman
University of Medical Sciences, Iran
maaflatoonian@gmail.com
Rezvan
Amiri
Department of Dermatology,
Afzalipour Hospital, Kerman
University of Medical Sciences, Iran
rezvanamiri1358@yahoo.com
Elham
Mohammadrezakhani
Kerman University of Medical
Sciences, Iran
10.22034/ijd.2020.104828
<strong>Background:</strong> Atopic dermatitis is the most common inflammatory skin disease in children. Severe itching may lead to an impaired quality of life in the patients. In this study, we evaluated the validity and reliability of Persian version of a questionnaire regarding the infants’ dermatitis quality of life in children suffering from atopic dermatitis.<br /><strong>Methods:</strong> When the original authors approved of the Persian version of the questionnaire, the parents completed the questionnaire for their 98 children with atopic dermatitis aged less than four years. We analyzed the data by SPSS 16. Cronbach’s alpha and inter-item and calculated the correlations to evaluate the reliability and validity via Kaiser criterion and scree plot.<br /><strong>Results:</strong> The calculated mean score of questionnaire was 9.65±5.41. The first (itching and scratching) and eight questions (treatment problems) obtained the highest and lowest scores, respectively. There was a strong, positive correlation between the severity of the disease and the quality of life score in the patients. Cronbach’s alpha was calculated as 0.88 which is a sign of good internal consistency of the items. The inter-item correlative coefficients varied between -0.004 to 0.87. We used Kaiser’s criterion and scree plot to evaluate the validity and achieve a two-factor solution.<br /><strong>Conclusion:</strong> Persian version of infants’ dermatitis quality of life index questionnaire was valid and reliable.
Validity,Reliability,Persian,Dermatitis,quality of Life Index
https://www.iranjd.ir/article_104828.html
https://www.iranjd.ir/article_104828_16559b15093b507e390cd08188aa700f.pdf
Iranian Society of Dermatology
Iranian Journal of Dermatology
2717-0721
22
4
2020
01
01
Pattern of pediatric dermatoses and seasonal variations in a tertiary referral center in central India
145
150
EN
Sarika
Pawar
Department of Dermatology,
Venereology and Leprology,
Government Medical College &
Hospital, Nagpur, Maharashtra, India
Vaishali
H.
Wankhade
Department of Dermatology,
Venereology and Leprology,
Government Medical College &
Hospital, Nagpur, Maharashtra, India
vshingade73@yahoo.com
Bhagyashree
B.
Supekar
Department of Dermatology,
Venereology and Leprology,
Government Medical College &
Hospital, Nagpur, Maharashtra, India
bhagyashreesupekar.23@gmail.com
Rajesh
Pratap Singh
Department of Dermatology,
Venereology and Leprology,
Government Medical College &
Hospital, Nagpur, Maharashtra, India
10.22034/ijd.2020.104829
<strong>Background:</strong> Skin diseases in the pediatric population are common worldwide, including rural and urban areas. There is a variation in the pattern and presentation of dermatoses, with eczemas being the most common skin disorder in developed countries and infestations in the developing countries. To study pattern, age-gender wise distribution and seasonal variations of various pediatric dermatoses.<br /><strong>Methods:</strong> All children in the age group of 1-12 years of either sex were recruited in the dermatology outpatient department from November 2014 to October 2016.<br /><strong>Results:</strong> Infections and Infestations were the most common dermatoses (46.3%), followed by dermatitis and eczema (20.24%). Among, the most common types of infections and infestations were scabies (33.49%), followed by viral (30.4%), and bacterial (23.3%) infections. Impetigo (P<0.001), furunculosis (P=0.025), molluscumcontagiosum (P<0.001), hand foot mouth disease (P=0.004) and atopic dermatitis (P=0.003) were significantly higher in the age group of 1 4 years. We also found a significant association between the seasonal variation and the bacterial infections, pediculosis and varicella.<br /><strong>Conclusion:</strong> In our study, skin infections and infestations outnumbered other pediatric dermatoses. These are potentially controllable and hence strategies that target infections and infestations may be a key to an efficient child health care program.
Pediatric dermatoses,Seasonal variations,central India
https://www.iranjd.ir/article_104829.html
https://www.iranjd.ir/article_104829_64294d9a03d87400cd7c13dab2c50a5d.pdf
Iranian Society of Dermatology
Iranian Journal of Dermatology
2717-0721
22
4
2020
01
01
A comprehensive review on vitamin D receptor (VDR) gene polymorphism in immune-related diseases with emphasis on dermatologic disorders
151
160
EN
Azadeh
Goodarzi
0000-0002-6913-3210
Department of Dermatology, Rasoul
Akram Hospital, Iran University of
Medical Sciences, Tehran, Iran
goodarzi.a@iums.ac.ir
10.22034/ijd.2020.104830
There are many immune mediated disorders with the corroborated role of vitamin D or Vitamin D Receptor (VDR) gene polymorphisms in their pathogenesis, immunologic regulation, and disease characteristics. Therefore, in this review, we searched PubMed data base in regard to the role of VDR gene polymorphisms in common autoimmune disorders, emphasizing on dermatologic diseases.
Vitamin D,Genetic polymorphism,Autoimmune Diseases
https://www.iranjd.ir/article_104830.html
https://www.iranjd.ir/article_104830_a9c84cde7d3d4bb09972dfbc7c65141b.pdf
Iranian Society of Dermatology
Iranian Journal of Dermatology
2717-0721
22
4
2020
01
01
Treatment of varicella skin scars with sequential punch elevation, autologous fat injection and fractional CO2 laser
161
164
EN
Reza
Kavoussi
Kermanshah University of Medical
Sciences (KUMS), Kermanshah,
Iran
kavoussi_1387@yahool.com
Hossein
Kavoussi
Dermatology Department, Hajdaie
Dermatolgy Clinic, Kermanshah
University of Medical Sciences
(KUMS), Kermanshah, Iran
hkawosi@kums.ac.ir
10.22034/ijd.2020.104831
Varicella is a common viral infection that occasionally results in scar. Despite a number of measurements taken to combat this infection, they have all been either impractical or limited.The current study presents a 28-year-old woman diagnosed with varicella 10 years ago which caused her to have several depressed skin scars over the face. She was subjected to sequential treatment of punch elevation, fractional CO<sub>2</sub> laser therapy, and autologous fat injection in one session. Over two years of postoperative follow-up, remarkable aesthetic improvements were observed in her face. This method had some advantages including high speed, convenience, application of conventional medical devices, and the minimal manipulation. The only limitation of our method was mild-to-moderate improvement of the previous hyperpigmentation of the scar.
varicella scar,punch,autologous fat,CO2 laser
https://www.iranjd.ir/article_104831.html
https://www.iranjd.ir/article_104831_ad272f0b7355dc8727195fdfc2c86200.pdf