TY - JOUR ID - 100199 TI - Comparison between the therapeutic effect of microneedling versus tretinoin in patients with comedonal acne: a randomized clinical trial JO - Iranian Journal of Dermatology JA - IJD LA - en SN - AU - Mehran, Golnaz AU - Sepasgozar, Saba AU - Rohaninasab, Masoomeh AU - Goodarzi, Azadeh AU - Ghassemi, Mohammadreza AU - Fotooei, Mahrokh AU - Behrangi, Elham AD - Department of Dermatology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran AD - Y1 - 2019 PY - 2019 VL - 22 IS - 3 SP - 87 EP - 91 KW - Acne KW - comedone KW - microneedling KW - Tretinoin DO - 10.22034/ijd.2019.100199 N2 - Background: Microneedling has been shown to be a clinically effective and safe treatment for comedonal acne vulgaris. The aim of the present study was to compare the clinical effectof microneedling and the most commonly used topical drug, tretinoin, in the treatment of comedonal acne.Methods: Patients with comedonal acne (n = 82) were randomized to receive topical tretinoin (n = 41) or 6 sessions of microneedling (n = 41) over a period of 3 months. Objective assessments suchas changes in acne severity score by global acne grading system (GAGS) and patients’ subjective satisfaction were investigated at the baseline, at the end of the treatment period, and at the3-month follow up.Results: GAGS was significantly reduced in both microneedling (7.8±3.8 to 3.5±2.6) and tretinoin (8±3.8 to 6.6±3.2) groups at the end of the treatment course compared with the baseline. Theoverall acne severity index reduction in microneedling group was significantly higher than that of the tretinoin group (P<0.001). Improvement in acne severity was also more permanent bymicroneedling. The severity of acne in tretinoin recipients was increased to 8.2±3.2 at the follow-up visit, while it remained nearly unchanged in the microneedling group. (3.3±2.4). Patients’subjective assessment concerning acne improvement was significantly more satisfactory in microneedling group (P<0.001). Conclusion: Compared with tretinoin, microneedling seems to be a more effective, permanent and satisfactory treatment in the treatment of comedonal acne. UR - https://www.iranjd.ir/article_100199.html L1 - https://www.iranjd.ir/article_100199_17b3901512f6a7d987df9c24299a856d.pdf ER -