TY - JOUR ID - 100208 TI - Generalized granuloma annulare: a report of 2 cases and literature review JO - Iranian Journal of Dermatology JA - IJD LA - en SN - AU - How, Kang Nien AU - Bakrin, Ikmal Hisyam AU - Shamsudin, Norashikin AD - Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia AD - Department of Pathology, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Malaysia Y1 - 2019 PY - 2019 VL - 22 IS - 3 SP - 115 EP - 119 KW - generalized granuloma annulare KW - pallisade KW - interstitial KW - hydroxychloroquine KW - Diabetes Mellitus DO - 10.22034/ijd.2019.100208 N2 - Granuloma annulare (GA) is an idiopathic benign skin disease, characterized by annular dermal plaques or papules. Much is still unknown concerning its aetiology, association, and pathogenesis.We report two patients with generalized GA (GGA), with different age of presentation, co-morbidities, and disease morphology. Herein, we report two patients with GGA with different clinical features, disease morphologies, and histology patterns. We also illustrate the treatment used in our patients and the outcome. GA is a self-limiting disease and can regress spontaneously. GGA tends to be more persistent and usually requires treatment for symptomatic or cosmetic reasons. Expert consensus on treatments recommends topical corticosteroid, psoralen and ultraviolet A (PUVA), and antimalarial drugs. UR - https://www.iranjd.ir/article_100208.html L1 - https://www.iranjd.ir/article_100208_b621cd93c3b21dc5f4a99fe521bded2f.pdf ER -