TY - JOUR ID - 98488 TI - Efficacy of combined triple therapy (Paramomycin ointment, cryotherapy and intralesional Glucantime) in comparison with intralesional Glucantime for the treatment of acute cutaneous Leishmaniasis JO - Iranian Journal of Dermatology JA - IJD LA - en SN - AU - Nilforoush Zadeh, MA AU - Jaffari, F AU - Malek Afzali, B AD - Y1 - 2004 PY - 2004 VL - 7 IS - 3 SP - 136 EP - 139 KW - Leishmaniasis KW - glucantime KW - Cryotherapy KW - Paramomycin DO - N2 - Background: In spite of different methods of treatment, there is not a simple, safe and complete curative treatment for cutaneous Leishmaniasis (CL), yet. Objective: To compare the efficacy of intralesional Glucantime injection alone, with the combined triple therapy of cryotherapy, paramomycin ointment and intralesional Glucantime in the treatment of CL. Materials and methods: 157 patients with CL were randomly allocated into 2 groups, 81 patients in group 1 were injected with intralesional Glucantime (Twice a week up to healing to the lesions or maximum 6 weeks). 76 patients in group 2 were treated with Paramomycin ointment (15% in 10% urea, twice a day), cryotherapy (Maximum 3 times 2 weeks) apart and injection of intralesional Glucantime (Once a week), for the same period as group 1. Results: After 6 weeks, complete cure rate in group 2 (89.5%) was significantly more than group 1 (70.4%) (P<0.05). Conclusion: Our results indicating of more efficacy of the triple therapy is in accordance with the previous studies of combined cryotherapy and Paramomycin. It could be recommended as a better treatment modality for CL wherever possible. UR - https://www.iranjd.ir/article_98488.html L1 - https://www.iranjd.ir/article_98488_74404ff52c5911cd33770d06c4dc9b2f.pdf ER -