2024-03-28T20:22:09Z
https://www.iranjd.ir/?_action=export&rf=summon&issue=15277
Iranian Journal of Dermatology
Iran J Dermatol
2020
23
3
Association between metabolic syndrome and acne in teenage girls: a cross-sectional study
Ghazal
Shariatpanahi
Rezvan
Hashemi
Mahsa
Asadabadi
Nava
Shirzadi
Nazgol
Sadat Haddadi
Safoura
Shakoei
Background: Acne is a common chronic inflammatory skin disease predominantly occurring during adolescence; this condition adversely affects a person’s self-esteem and can be associated with metabolic disorders. This study aimed to investigate the prevalence of metabolic syndrome and its components in adolescent girls with acne compared to a control group. Materials and Methods: In this cross-sectional study,105 adolescent girls aged 12-18 years were assigned to either the acne (case; n=55) or control group (n=50). The case group was selected from the Dermatology Department of a general hospital in Tehran, Iran, between January and August 2017. Acne lesions were confirmed and graded by a dermatologist. Clinical and biochemical parameters were evaluated for all participants. Results: The prevalence of metabolic syndrome in patients with and without acne was 18.2% and 14%, respectively. As a result, metabolic syndrome was not correlated with acne in adolescent girls (P=0.561). In addition, the mean body mass index (P=0.89), waist circumference (P=0.62), mean systolic and diastolic blood pressures (P=0.57 and 0.62, respectively), fasting blood sugar (P=0.59), total cholesterol, and low-density lipoprotein cholesterol levels were comparable between the studied groups (P>0.05). Moreover, triglyceride levels were significantly lower in the acne group (P=0.028), whereas this group featured a higher level of high-density lipoprotein cholesterol (P=0.02). However, the logistic regression results showed that none of the measured lipids were associated with acne. Conclusion: The findings indicated that metabolic syndrome and its components (representing metabolic imbalance) were not correlated with acne in adolescent girls.
Acne Vulgaris
Metabolic Syndrome
Adolescent
2020
10
01
85
90
https://www.iranjd.ir/article_111544_eca1c1f38385e78f3feed2a1a5f9e157.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2020
23
3
Quality of life of psoriatic patients and their acceptance of the disease
Shrouk
Aladl
Abdel-Hady
El-Gilany
Bothaina
Ghanem
Hassan
Fayed
Background: Psoriasis and its acceptance adversely affect the patient’s quality of life. This study aims to measure quality of life of psoriatic patients, psoriasis disability index and acceptance of psoriasis as a disease and their associated factors as well as their interaction. Methods: A total of 125 psoriatic patients were included in the study. Socio-demographic and clinical data were collected. Psoriasis Area Severity Index (PASI), Psoriasis quality of life index (PQOL), Psoriasis Disability (PDI) and acceptance of psoriasis scale index (PAI) were measured using Arabic validated tools. Multivariate linear regression analysis was done to find out the independent predictors of the outcome variables. Results: The mean overall PQOL, PDI and PAI were 14.3, 20.8 and 60.1; respectively. Compared to the moderate/severe chronic plaque psoriasis, the mild chronic plaque shows significantly lower mean PQOL, lower mean PDI and higher mean PAI. There are positive moderate significant correlations between PQOL and PDI and PASI (r=0.59, r=0.54; respectively). However, there is inverse moderate significant correlation between PQOL and psoriasis acceptance index (r=-0.55). The linear regression revealed that the independent predictors of psoriasis quality of life are PDI, PASI and PAI. These three variables predict 0.42 of variability of PQOL. Conclusion: psoriasis exerts significant, negative effect on patients' quality of life. Disease disability, severity and its acceptance are independent predictors of quality of life.
Area Severity Index
Disability
Egypt
2020
10
01
91
97
https://www.iranjd.ir/article_111545_5293966fd964a0bf21629181b1308a7f.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2020
23
3
Safety and efficacy of fluoxetine in the treatment of acne excoriée: a double-blind, placebo-controlled study
Balakrishna P
Nikam
Mohan
Kale
Varsha
Jamale
Tunika
Arora
Asma
Hussain
Nishchhal
Shrivastav
Background: Self-inflicted acne excoriée is often observed in patients with compulsive skin picking, posing a challenge for diagnosis and treatment as the exact psychiatric cause remains unknown. Studies have suggested that serotonin reuptake inhibitors such as fluoxetine may help in the management of this condition. To determine the efficacy and safety profile of fluoxetine in the treatment of acne excoriée and to study the psychological profiles of patients. Methods: Sixty patients of either sex aged ≥16 years with acne excoriée were assigned to either Group A (n=30), which received oral fluoxetine (F) (20 mg/day) and oral doxycycline (D) (100 mg/day) with topical clindamycin (1%), or Group B (n=30), which received a placebo (P), oral doxycycline (100 mg/day), and topical clindamycin (1%). Patients were evaluated for standardized rating scales and followed up every two weeks for 12 weeks. Results: Female gender predominance was observed in both groups, with most patients exhibiting anxiety and depression. With each follow-up visit (2nd, 3rd, 4th, and 5th) in both groups (A and B), the mean AESI (91.4% vs. 26.7%), HAM-A (80% vs. 27.7%), MADRS (68.1% vs. 28.2%), YBOCS (98.27% vs. 15.63%), PGA (88.47% vs. 31.38%), and VAS (99.17% vs. 37.67%) scores decreased from baseline by the final visit, indicating improved patient conditions. Significant differences were observed between the two groups (p <0.001) in the overall response, indicating that fluoxetine was more efficacious than the control. No remarkable side effects were noted. Conclusion: Fluoxetine efficiently managed acne excoriée without remarkable side effects. Background: Self-inflicted acne excoriée is often observed in patients with compulsive skin picking, posing a challenge for diagnosis and treatment as the exact psychiatric cause remains unknown. Studies have suggested that serotonin reuptake inhibitors such as fluoxetine may help in the management of this condition. To determine the efficacy and safety profile of fluoxetine in the treatment of acne excoriée and to study the psychological profiles of patients. Methods: Sixty patients of either sex aged ≥16 years with acne excoriée were assigned to either Group A (n=30), which received oral fluoxetine (F) (20 mg/day) and oral doxycycline (D) (100 mg/day) with topical clindamycin (1%), or Group B (n=30), which received a placebo (P), oral doxycycline (100 mg/day), and topical clindamycin (1%). Patients were evaluated for standardized rating scales and followed up every two weeks for 12 weeks. Results: Female gender predominance was observed in both groups, with most patients exhibiting anxiety and depression. With each follow-up visit (2nd, 3rd, 4th, and 5th) in both groups (A and B), the mean AESI (91.4% vs. 26.7%), HAM-A (80% vs. 27.7%), MADRS (68.1% vs. 28.2%), YBOCS (98.27% vs. 15.63%), PGA (88.47% vs. 31.38%), and VAS (99.17% vs. 37.67%) scores decreased from baseline by the final visit, indicating improved patient conditions. Significant differences were observed between the two groups (p <0.001) in the overall response, indicating that fluoxetine was more efficacious than the control. No remarkable side effects were noted. Conclusion: Fluoxetine efficiently managed acne excoriée without remarkable side effects. Keywords: acnevulgaris,fluoxetine, doxycycline
Acne Vulgaris
fluoxetine
Doxycycline
2020
10
01
98
104
https://www.iranjd.ir/article_111546_33abf72dc67c17db2ae92b5bbabf79eb.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2020
23
3
Clinical and epidemiological profile of psoriasis patients: a retrospective study in tertiary medical centers, Mangalore, India
Nitin
Joseph
Deepti
D’Souza
Matthew
Manoj
Shajimon
Varsha
Tanya
Singh
Archit
Gupta
Akshiti
Kaushik
Background: Psoriasis is an immune-mediated chronic skin disorder. Information regarding its clinic-epidemiological manifestations is limited in parts of Asia. This study was conducted to determine the risk factors, clinical presentation, and management of psoriasis among patients in Mangalore, India. Methods: The medical records of 225 psoriasis patients over the past ten years (from January 2009 till March 2019) were examined by the investigators. Data were collected using a semi-structured form. Results: The mean age at diagnosis of psoriasis was 42.2 ± 16.0 years. Nail psoriasis and psoriatic arthritis (PsA) were present in 66 (29.3%) and 21 (9.3%) patients, respectively. Relapse of psoriasis was seen more among patients with a history of disease exacerbation in winter (P=0.009) or in rainy seasons (P=0.031). Systemic therapy with methotrexate and topical therapy with steroids were used in the management of 52 (23.1%) and 72 (32%) patients, respectively. Phototherapy (n=11) was the most common modality used among the 18 patients with extensive psoriasis. Co-morbidities like diabetes mellitus (P=0.02) and complications like PsA (P=0.008) were associated with greater disease durations among the patients. Conclusion: The proportion of patients with extensive psoriasis was high in the current setting probably because of delayed diagnosis. Awareness about the disease and its clinical manifestations might help in its early identification. Seasonal exacerbation was an important risk factor for psoriasis and it was associated with its relapse. The most common management modalities were topical steroids for psoriasis and phototherapy for extensive psoriasis.
Psoriasis
risk factors
psoriatic arthritis
2020
10
01
105
111
https://www.iranjd.ir/article_111547_fcf23b540caa2c08d80aea97f58ae1c7.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2020
23
3
Frontal fibrosing alopecia: a clinicopathological study of 22 cases from Shiraz, Southern Iran
Fatemeh
Sari Aslani
Nasrin
Saki
Mohammad
Sasannia
Background: Since its recognition, frontal fibrosing alopecia (FFA) has increasingly been studied globally in terms of its diverse aspects. Having found no studies describing this condition in Southern Iran, we examined the different clinicopathological features of patients with FFA who referred to Faghihi Hospital, Southern Iran, between 2013 and 2018. Methods: We searched the archives of the Pathology Department of Faghihi Hospital for the cases with a diagnosis of FFA. Due to its similar histopathologic features with lichen planopilaris, the final diagnosis was made using clinical correlations. Results: Twenty-two patients were enrolled; all were female. Fifteen (68.2%) presented with the disease before menopause. Besides frontal and/or temporal hairline involvement in all the patients, eyebrow alopecia, eyelash loss, body hair loss, and facial papules were present in 81.8%, 27.3%, 50%, and 68.2% of them, respectively. Dermoscopic findings included follicular opening loss (100%), honeycombing of the scalp (81.8%), multiple white dots (77.3%), perifollicular erythema (63.6%), and perifollicular scales (59.1%). The histopathologic examination revealed follicular dropout (95.4%), perifollicular lymphocytic infiltration in the infundibulum and isthmus of the follicles (81.8%), perifollicular fibroplasia (77.3%), intact interfollicular epidermis (59.1%), mild perivascular lymphocytic infiltration in the upper dermis (54.5%), and apoptotic keratinocytes in the infundibulum and isthmus (50%). The most common comorbidity was hypothyroidism (40.9%). Conclusions: Thediagnosis of FFA should be considered in both premenopausal and postmenopausal women. Eyebrow alopecia, eyelash loss, body hair involvement, and facial papules are helpful clues in the diagnosis. The coexistence of hypothyroidism with FFA suggests immunological involvement in the pathogenesis.
hair
Lichen Planus
eyebrows
Dermoscopy
Pathology
2020
10
01
112
119
https://www.iranjd.ir/article_111548_a43492418e415d187a10994c4c655ba2.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2020
23
3
Multidrug resistant Candida glabrata in an oral lichen planus patient
Ensieh
Lotfali
Alireza
Firooz
Azam
Fattahi
Mojgan
Borzouie
Behzad
Chalaki
Reza
Ghasemi
Mohammad Mahdi
Rabiei
Sareh
Farhadi
Seyed Amirfarshad
Esteghamat
Mobina
Habibollahi
Oral lichen planus (OLP) is a mucocutaneous disease characterized by inflammation leading to severe damage to the epithelial basal layer. This report describes a case of a 65-year-old Iranian female with a complaint of multifocal white lesions on the buccal and tongue mucosa with a reticular pattern and a focal pseudomembranous appearance (similar to thrush), together with burning symptoms for fourteen months. The patient was using topical fluocinolone acetonide 0.1%, two to three times a day at least for six months to control the ulcers and erythema. Molecular analysis of the thrush sample revealed Candida glabrata as the causative agent. Histopathologic examination confirmed the diagnosis of OLP. The minimum inhibitory concentration analysis was performed according to CLSI-M60 and revealed that this C. glabrata isolate was multidrug-resistant (resistant to nystatin, fluconazole, micafungin, and caspofungin). Finally, this patient was treated with amphotericin B oral suspension (0.5 g/5 ml) thrice daily for 14 days. The thrush disappeared completely and the patient no longer had any pain or burning sensations. Candida glabrata, the second most common cause of candidemia, is a major opportunistic fungal pathogen of humans that causes systemic as well as, mucosal and superficial infections. This case is the first case of OLP accompanied by multidrug-resistant C. glabrata.
Oral lichen planus
Candida glabrata
multidrug resistance
2020
10
01
120
124
https://www.iranjd.ir/article_111551_34cd32f9d383fa996a8dc19471c90ff7.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2020
23
3
Lichen planus pigmentosus successfully treated with conventional CO2 laser resurfacing
Ramin
Radmanesh
Mohammad
Radmanesh
Lichen planus pigmentosus (LPP) develops as an asymptomatic and dusky pigmentation of the facial skin with no effective treatment. Herein we report a 54-year-old lady with clinical and histopathologic confirmation of LPP who was scheduled to be treated with CO2 laser resurfacing. After tumescent anesthesia, the whole facial skin was treated with three passes of Ultrapulse conventional CO2 ablation. The energy used in the first, second, and third passes were 6.6, 5.4, and 4.8 mJ, respectively. The mandibular area was treated with two passes (4.2 and 3.6 mJ). The eye contours were treated with two passes (3.9 and 3.3 mJ). The patient’s face remained edematous for a week, with the facial skin oozing within the first three days before it became crusted. The crust shed out from day three to six. After a week, smooth and erythematous skin appeared. The erythema persisted for up to four months, after which uniform skin with considerable bleaching and rejuvenation developed. No recurrence occurred within 18 months of follow-up. We conclude that LPP can be treated with CO2 laser resurfacing without any complications.
Lichen Planus
CO2 laser
treatment
2020
10
01
125
128
https://www.iranjd.ir/article_111552_d9b347926fb4e39c0a1a2e3fe325e2ff.pdf
Iranian Journal of Dermatology
Iran J Dermatol
2020
23
3
Cutaneous reaction to the first dosage of Japanese encephalitis vaccine: a letter to editor
Beuy
Joob
Viroj
Wiwanitkit
cutaneous
reaction
Japanese Encephalitis
Vaccine
2020
10
01
129
130
https://www.iranjd.ir/article_111550_127cc89fa96b894aa4699b74c512326c.pdf