Narges Ghandi; Shaghayegh Tavassoli; Maryam Ghiasi; Vahideh Lajevardi; Robabeh Abedini; Hamid-Reza Tohidinik; Maryam Daneshpazhooh
Volume 19, Issue 2 , 2016, , Pages 35-39
Soheila Taheri; Ali Asilian; Gita Faghihi
Volume 12, Issue 2 , 2009, , Pages 36-41
Abstract
Background: Many efforts are made to find new and more effective treatments for psoriasis. Intralesional 5-Fluorouracil (5-FU) +epinephrine is a cheap option which can be administered with long intervals. The effectiveness of Pulse Dye Laser (PDL) on psoriasis has been already assessed. We decided to ...
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Background: Many efforts are made to find new and more effective treatments for psoriasis. Intralesional 5-Fluorouracil (5-FU) +epinephrine is a cheap option which can be administered with long intervals. The effectiveness of Pulse Dye Laser (PDL) on psoriasis has been already assessed. We decided to evaluate the effectiveness of 5-FU+epinephrine and compare it to betamethasone and PDL.Methods: A group of 22 patients with chronic stable plaque psoriasis were included. Three plaques on each patient were treated with 5- FU+epinephrine, PDL and betamethasone, respectively. Psoriasis Severity Index (PSI) scoring was applied to assess each plaque before treatment and in weeks 2, 4, 6, 12, and 24. Photos of each plaque were taken before treatment and at each treatment and follow-up session. They were finally compared and scored by a dermatologist.Results: Decline in mean Psoriasis Severity Index (PSI) in week 6 (2 weeks after treatment) and in week 24 (the last follow-up session) was statistically significant as compared to baseline in all groups. (P<0.001) The highest decline in mean PSI score was in the 5-FU+epinephrine group while the lowest belonged to the PDL group (80% vs. 27%).The mean period of remission in the 5-FU+epinephrine group was significantly longer in comparison to the two other groups. (P<0.001) In photographic evaluation, the best response was observed in the 5- FU+epinephrine group.Conclusion: 5-FU+epinephrine is a cheap option which can provide a rapid response and long remission .With respect to limited effectiveness, short remission and high cost; PDL dose not seem to be a preferred choice in the treatment of psoriasis.
Tafti Hossein Sadeghi; Ahmadikia Kazem; Rashidian Sara; Hekmatimoghaddam Seyed Hossein; Yazdi Zeinab Ayubi
Volume 20, Issue 2 , 2017, , Pages 37-42
Abstract
Background: Onychomycosis, the fungal infection of the toenails or fingernails, is caused by three major groups of fungi including dermatophytes, yeasts and non-dermatophyte molds. The objective of the present study was to determine the incidence of onychomycosis and to identify the causative fungi during ...
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Background: Onychomycosis, the fungal infection of the toenails or fingernails, is caused by three major groups of fungi including dermatophytes, yeasts and non-dermatophyte molds. The objective of the present study was to determine the incidence of onychomycosis and to identify the causative fungi during a one year period in Yazd, Iran. Materials and Methods: From Apr 2013 to Apr 2014 a total of 273 patients with suspected dermatophytosis were included in this study. Nail-clipping specimens of 71 clinically diagnosed cases of onychomycosis were obtained for mycological examination (KOH preparation and fungal culture). Identification of mycelial isolates was based on morphological appearance and microscopic characteristic of the colony. Supplementary methods for identification of dermatophytes were employed. The species of yeasts were identified by germ-tube and chlamydospore test, as well as colony color on chromogenic CHROMagar Candida medium, and the assimilation profile in API 20C Aux system. Results: Of the 71 patients affected by nail disorders, 26 (36.6%) patients of onychomycosis including 54.9% male and 45.1% female (20 fingernails, 6 toenails) via direct examination and/or culture methods were diagnosed. saprophytic fungi were the most prevailing causative agents of onychomycosis and account for up to 69.2%(n=18) of cases, yeasts and dermatophytes were identified as causative agents of onychomycosis in 7 (26.9%) patients and 1 patient (3.8%), respectively. Distribution of fungal isolates was as follows: Aspergillus niger (26.9%), A. fumigatus (19.2%), Candida albicans (15.3%), A. flavus (11.5%), C. tropicalis (7.6%), Penicillium sp. (7.6%), C. dubliniensis (3.8%), Trichophyton mentagrophytes (3.8%) and Fusarium sp. (3.8%). Conclusion: Because of considerable prevalence of onychomycosis, necessity for a careful mycological examination in patients with nail disorders is highlighted.
Dhaher Samer A; Alhamdi Dhoha Kh
Abstract
Background: Rosacea is a chronic inflammatory disease of unknown etiology. Few studies have been published on the use of oral ivermectin in the treatment of the inflammatory subset of rosacea. The aim of the present research was to evaluate the efficacy and safety of oral ivermectin prescribed for a ...
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Background: Rosacea is a chronic inflammatory disease of unknown etiology. Few studies have been published on the use of oral ivermectin in the treatment of the inflammatory subset of rosacea. The aim of the present research was to evaluate the efficacy and safety of oral ivermectin prescribed for a series of patients with inflammatory rosacea.
Methods: On a weekly basis, 29 patients with papulopustular rosacea were orally given ivermectin at a dose of 200 µg/kg before meal for three consecutive weeks. Subjects were evaluated weekly and during the follow-up period for two successive treatment-free months.
Results: After 3 doses of ivermectin, there was a significant reduction in the total count of inflammatory lesions compared to the base line (the mean was reduced from 51.6±27.4 to 21±14.7) (P<0.05). At the end of the two-month follow-up period, more reduction was observed in inflammatory lesions (mean was reduced to 9.3±7), and 62% of the patients showed excellent responses to the treatment (≥ 80% reduction in the lesions). Nausea was reported in 10%.
Conclusion: A three-week use of oral ivermectin is an effective, safe, and well-tolerated approach to treating inflammatory rosacea .
LA Goldsmith; JL Bolognia; JP Callen; SC Chen; SR Feldman; HW Lim; AW Lucky; BR Reed; EC Siegfried; DM Thiboutot; RG Wheeland
Volume 7, Issue 4 , 2004, , Pages 38-48
Tehranchinia Zohreh; Namazi Nastaran; Sarah Ershadi; Laya Rahbar Nikoukar; Gity Taheri
Volume 18, Issue 2 , 2015, , Pages 41-44
Abstract
Background: Androgenetic alopecia (AGA) is a non-scarring alopecia which consists of miniaturization of the terminal hair under the influence of androgens. Some scholars have reported an association between AGA and coronary artery disease (CAD), probably due to alterations in CAD risk factors. However, ...
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Background: Androgenetic alopecia (AGA) is a non-scarring alopecia which consists of miniaturization of the terminal hair under the influence of androgens. Some scholars have reported an association between AGA and coronary artery disease (CAD), probably due to alterations in CAD risk factors. However, this association is not supported by other studies, thus rendering the subject open to discussion.Methods: A total of 100 women were enrolled in this study: 50 diagnosed with AGA based on physical examination and 50 agematched controls. BMI as well as serum total cholesterol, highdensity lipoprotein (HDL-C), low-density lipoprotein (LDL-C), and triglyceride were measured.Results: The mean BMI was 25.3±3.5 kg/m2 in the AGA group and 24.2±3.4 kg/m2 in the control group (P=0.11). The mean level of triglyceride, total cholesterol, HDL-C, and LDL-C in the AGA group was 141.7±55.4 mg/dl, 194.9±35.8 mg/dl, 41.1±12.3 mg/ dl, and 129.7±32.6 mg/dl, respectively. These figures showed no significant difference in the control group (P=0.10)Conclusion: It seems that a diagnosis of AGA in female patients is not linked to increased serum lipids.
Simin Shamsi Meymandi; Manzumeh Shamsi Meymandi; Soodabeh Zandi; Shahriar Dabiri; Mahin Aflatoonian
Volume 14, Issue 2 , 2011, , Pages 42-47
Abstract
Background: Cutaneous leishmaniasis (CL) is a major world problem. Several types of treatment regimens have been suggested. Imiquimod demonstrated a leishmanicidal activity by increasing local cytokine production. The aim of this study was to determine the efficacy of topical 5% imiquimod with cryotherapy ...
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Background: Cutaneous leishmaniasis (CL) is a major world problem. Several types of treatment regimens have been suggested. Imiquimod demonstrated a leishmanicidal activity by increasing local cytokine production. The aim of this study was to determine the efficacy of topical 5% imiquimod with cryotherapy vs. intralesional meglumine antimoniate (MA) in treatment of anthroponotic (dry type) CL. Method: This is a prospective, randomized, open trial study (from Iran) from September 2008 to September 2010, including 50 patients (25 patients in the combined imiquimod and cryotherapy group and 25 patients in the intralesional MA group). Patients were randomly assigned to receive combined cryotherapy biweekly with imiquimod three times per week or intralesional MA weekly until complete cure or up to 12 weeks, whichever earlier. The primary end point was clinical cure, defined as complete re-epitelialization of 100%, complete flattening of induration compared with baseline at weeks 2, 6, 12 and follow up were done 1, 2 and 3 months after complete cure. Results: 50 participants divided into 25 patients in group A and 25 patients in group B completed the study. Complete cure was 65.5% (16/24 patients) in group A and 83.3% (19/23 patients) in group B. No complication was detected in patients treated with MA. Pain and eczematous reaction were detected by 4 patients and local infection in 1 patient treated with imiquimod. Conclusion: Although Meguimine antimoniate seems to be a more effective therapy for cutaneous leishmaniasis, this study revealed no significant difference in clinical response between combination of imiquimod and cryotherapy with intralesional MA in patients with cutaneous leishmaniasis in an endemic area of L. tropica.
Tehranchinia Zohreh; Niroomand Mahtab; Kazeminejad Armaghan; Ghahari Mohammad Jafar; Radvar Siamak Esmaeili; Sadat-Amini Seyed Hadi; Younespour Shima; Partovi-Kia Masoud
Volume 17, Issue 2 , 2014, , Pages 43-48
Abstract
Background: Leptin, a 16-KDa peptide hormone secreted from theadipose tissue, plays an important role in the regulation of energyintake and expenditure and body weight regulation; furthermore,it has a regulatory function on the reproductive system. The aimof this study was to assess the relationship ...
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Background: Leptin, a 16-KDa peptide hormone secreted from theadipose tissue, plays an important role in the regulation of energyintake and expenditure and body weight regulation; furthermore,it has a regulatory function on the reproductive system. The aimof this study was to assess the relationship between serum leptinlevels and sex hormones in psoriatic patients and control groupand to determine the serum levels of leptin and sex hormones inpatients and their association with disease severity.Method: This cross-sectional study included 43 male patientswith psoriasis and 42 age- and sex- matched healthy controls. Wemeasured serum levels of leptin, sex hormone-binding globulin(SHBG), luteinizing hormone (LH), follicle stimulating hormone(FSH), prolactin, and total testosterone in both groups.Result: Psoriatic patients had si
Safoura Shakoei; Nazanin Nasri; Ghazal Shariatpanahi; Rezvan Hashemi
Abstract
Background: Acne is a chronic inflammatory skin disease and a cosmetic problem with considerable emotional and psychological side effects and symptoms, such as pain and pruritus. Some controversies exist concerning the involvement of dietary factors, including glycemic load (GL), ...
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Background: Acne is a chronic inflammatory skin disease and a cosmetic problem with considerable emotional and psychological side effects and symptoms, such as pain and pruritus. Some controversies exist concerning the involvement of dietary factors, including glycemic load (GL), in the pathogenesis of acne. Accordingly, we aimed to determine the role of GL and anthropometric measures in acne development among girls aged 12-18 years in Tehran, Iran.Methods: In this cross-sectional study, 99 girls (45 girls without acne and 54 girls with acne) aged 12 18 years completed a threeday food record. Anthropometric measures, such as height, weight, waist circumference, and body mass index (BMI), were also assessed. Additionally, an expert dermatologist scored the severity of acne, and then, anthropometric measures and GL were examined in the groups.Results: The results showed no significant difference in dietary GL, height, weight, BMI, and waist circumference between the groups. Furthermore, the severity of acne was not significantly associated with GL.Conclusion: The present results did not confirm the association between acne and dietary carbohydrates, including GL. However, further research can contribute to determination of the effect of diet on acne and its severity.
Pezeshkpoor Fakhrozaman; Tohidi Mohammad; Layegh Pouran; Shahabi Majid
Volume 16, Issue 2 , 2013, , Pages 45-48
Abstract
Background: Accurate diagnosis of cutaneous leishmaniasis wouldavoid unnecessary treatment and scar formation. Direct smear isthe most common method for the diagnosis of this disease but itsnegative result could not rule out the infection; so, the need formore sensitive methods is obvious. We conducted ...
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Background: Accurate diagnosis of cutaneous leishmaniasis wouldavoid unnecessary treatment and scar formation. Direct smear isthe most common method for the diagnosis of this disease but itsnegative result could not rule out the infection; so, the need formore sensitive methods is obvious. We conducted this study tocompare the efficiency of direct skin smear with smears preparedby fine needle aspiration (FNA) using polymerase chain reaction(PCR) as a reference method.Methods: In this cross-sectional study, which was conductedduring two years from May 2008 to May 2010, 33 patients withsuspicious acute cutaneous leishmaniasis based on clinical studieswere randomly selected. Direct skin smears and FNA smearswere taken from each patient and PCR was performed on biops
Behrangi Elham; Sadeghi Somayeh; Sadeghzadeh-Bazargan Afsaneh; Goodarzi Azadeh; Ghassemi Mohammadreza; Sepasgozar Saba; Rohaninasab Masoomeh
Abstract
Background: Insulin resistance and increased insulin-like growth factor (IGF)-1 with consequent mammalian target of rapamycin complex (mTORC) 1 overexpression is responsible for acne pathogenesis, especially in women with polycystic ovary syndrome (PCOS). Metformin is shown to improve acne as an adjunct ...
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Background: Insulin resistance and increased insulin-like growth factor (IGF)-1 with consequent mammalian target of rapamycin complex (mTORC) 1 overexpression is responsible for acne pathogenesis, especially in women with polycystic ovary syndrome (PCOS). Metformin is shown to improve acne as an adjunct therapy in females with PCOS and males with altered metabolic profile. We evaluated the use of metformin in the treatment of resistant and late-onset acne in females, and compared it with isotretinoin.
Methods: Females with late-onset acne or acne resistant to common therapies (n=70) were randomized to receive metformin (n=35) or isotretinoin (n=35) for 6 months. Changes in acne severity were scored by global acne grading system (GAGS) which was the primary outcome. Other endpoints were changes in the components of metabolic profile.
Results: Six-month treatment with metformin and isotretinoin significantly reduced the GAGS from 31.9 to 24.6 and from 34.1 to 13.3, respectively, indicating the superior impact of isotretinoin. Metfromin was more effective in decreasing the GAGS score in those with PCOS (13.5±7.1 vs. 24.2±19.4, P<0.05). Furthermore, patients with hirsutism had a higher reduction score with metformin compared to patients without hirsutism (21.1±9.1 vs. 30.2±6.4) (P<0.05). Lipid profile and fasting blood sugar were improved following the 6-month treatment with metformin, and isotretinoin increased the levels of liver enzymes and bilirubin (P<0.05).
Conclusion: Metformin is effective in treating late-onset or resistant acne and improving metabolic status, without serious side effects. In patients with altered metabolic profiles such as PCOS, metformin seems to be superior to isotretinoin regarding acne treatment.
Davari Parastoo; Gorouhi Farzam; Jafarian Sirous; Firooz Alireza
Volume 11, Issue 2 , 2008, , Pages 49-54
Abstract
Background: Microdermabrasion has recently become a popular procedure among physicians and patients, whereas few studies have assessed the efficacy of different microdermabrasion protocols nowadays applied.The objective of this study was to assess the effects of microdermabrasion, as well as to compare ...
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Background: Microdermabrasion has recently become a popular procedure among physicians and patients, whereas few studies have assessed the efficacy of different microdermabrasion protocols nowadays applied.The objective of this study was to assess the effects of microdermabrasion, as well as to compare the effects of weekly and biweekly intervals of microdermabrasion sessions on skin biophysical parameters. Methods: Ten patients entered this randomized, investigator-blind, split face study and underwent a series of six microdermabrasion treatments. One side of the face was treated every week and the other side was treated every 2 weeks, randomly. Stratum corneum hydration, sebum secretion and skin pH measurements were taken before and after the procedure on all sessions and also 1 and 4 weeks after the last treatment. Results: After 6 sessions of microdermabrasion and following comparison to baseline, a significant decrease in sebum content and a significant increase in skin pH were observed only on the side treated with the intervals of 2 weeks. Changes in skin hydration were not significant on either side. Conclusion: Microdermabrasion may have noticeable effects on skin barrier functions. It is recommended to have 2 week interval between sessions.
Shahidi-Dadras Mohammad; Farnaghi Ali; Tehranchinia Zohreh; Rahimi Hoda; Saeedi Marjan; Ghaemi Marjan
Volume 13, Issue 3 , 2010, , Pages 67-70
Abstract
Introduction: Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membrane. Antiphospholipid antibodies are a group of autoantibodies found in patients with autoimmune diseases. Due to the risk for thrombotic events in autoimmune diseases, we decided to evaluate the correlation ...
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Introduction: Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membrane. Antiphospholipid antibodies are a group of autoantibodies found in patients with autoimmune diseases. Due to the risk for thrombotic events in autoimmune diseases, we decided to evaluate the correlation between pemphigus vulgaris and predictive elements of atherothrombosis including antiphospholipid antibodies and homocysteine. Methods: IgG and IgM anticardiolipin antibodies, IgG anticardiolipinbeta 2 glycoprotein I, lupus anticoagulant and total homocysteine were evaluated in the serum of 39 new cases of pemphigus vulgaris and healthy matched controls. Results: The prevalence of antiphospholipid antibodies, lupus anticoagulant and total homocysteine in pemphigus vulgaris patients showed no significant difference with healthy controls. Conclusion: Pemphigus vulgaris seems not to be similar to some other organ specific autoimmune diseases in which there is an increase in atherothrombotic factors including antiphospholipid antibodies and homocysteine.
Kuppusamy Meera; Taib Tarita binti; Asmah Johar; Abdul Manan bin Mat Jais
Volume 19, Issue 3 , 2016, , Pages 67-72
Abstract
Background: Channa striatus or better known as the haruan fish is an indigenous, snakehead, striped, air breathing freshwater fish of Malaysia and has long been consumed traditionally during post-operative and post-partum period to speed recovery. Most medical properties of the haruan are contributed ...
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Background: Channa striatus or better known as the haruan fish is an indigenous, snakehead, striped, air breathing freshwater fish of Malaysia and has long been consumed traditionally during post-operative and post-partum period to speed recovery. Most medical properties of the haruan are contributed to its high content of essential fatty and amino acids. This was a phase I clinical trial to examine the safety of Channa striatus (CS) 5% cream with patch testing and cumulative dosing for up to 4 weeks on the healthy skin. Methods: This double-blind randomized controlled trial was conducted in two stages. Eighty-three participants who fulfilled the inclusion criteria underwent patch testing. The allergens, aqueous and CS 5% cream, were patch tested simultaneously but separately on each arm of the same participant. The participants with a negative patch test started stage 2, whereby they applied randomly assigned creams on both forearms for a duration of 1 month. Results: A total of 83 participants were screened successfully and underwent patch testing. One participant in the cohort developed a positive patch test to CS 5% and was excluded from stage 2. Two participants experienced mild side effects that resolved with mild topical steroid. The incidence of allergic contact dermatitis and irritant contact dermatitis was 1.2% and 2.4% in the participants, respectively. Conclusion: The uniquely Malaysian Channa striatus 5% cream has a good safety profile. Information on the safety and tolerability obtained from this study can be used to design larger phase II studies in patients with inflammatory skin conditions.
Mashayekhi Vahid; Mahmoudi Mahmoud; Rastin Maryam; Tayebi Naser; Taheri Ahmad Reza; Tavakoli Maryam
Volume 15, Issue 3 , 2012, , Pages 69-73
Abstract
Background: Chronic lupoid leishmaniasis (CLL) is a chronicform of cutaneous leishmaniasis that is usually resistant to antileishmania agents and leishmania is not seen in the histologicsections. We used polymerase chain reaction (PCR) to detectleishmania DNA in CLL specimens.Method: This descriptive ...
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Background: Chronic lupoid leishmaniasis (CLL) is a chronicform of cutaneous leishmaniasis that is usually resistant to antileishmania agents and leishmania is not seen in the histologicsections. We used polymerase chain reaction (PCR) to detectleishmania DNA in CLL specimens.Method: This descriptive cross sectional study was done on20 paraffin embedded specimens of CLL cases referred to thedermatology clinic of Imam Reza Hospital, Mashhad, Iran.Patients’ information including age, sex, duration and location ofthe lesion was obtained and then skin specimens were reviewedhistopathologically and assessed for leishmania DNA using PCR.Result: Eleven male and 9 female patients with a mean age of17.95 years were included in our study. The
Lajevardi Vahideh; Ghiasi Maryam; Falahati Ali Asghar; Goodarzi Azadeh
Volume 20, Issue 3 , 2017, , Pages 69-74
Abstract
Background: Vitiligo is an acquired skin discoloration with melanocytic destruction. Vitiligo is associated with other autoimmune disorders; hence, an autoimmune etiology is among the most important theories for this disorder. The nails can be involved in numerous cutaneous or systemic non-cutaneous ...
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Background: Vitiligo is an acquired skin discoloration with melanocytic destruction. Vitiligo is associated with other autoimmune disorders; hence, an autoimmune etiology is among the most important theories for this disorder. The nails can be involved in numerous cutaneous or systemic non-cutaneous disorders. We have taken into consideration previous studies on nail abnormalities in vitiligo and alopecia areata (AA), which are ethologically closely-related, in addition to the few, notwell designed studies on nail changes in vitiligo, and lack of similar studies in Iran. This case-control study was conducted to evaluate the autoimmune etiology of vitiligo with a larger number of participants.Methods: In this case-control study, we assessed the nail characteristics of 303 participants at Razi Hospital, Tehran, Iran from 2013-2014. These changes were also assessed in terms of diseases properties of the case group and included distribution, duration, and presence of other concomitant cutaneous disorders.Results: There was a statistically significant odd’s ratio (OR) for leukonychia in the case and control groups. The relationship between the prevalence of leukonychia and disease duration was meaningful (P0.05). There was no other significant difference between each type of nail abnormality in the case and control groups. We observed no association between these abnormalities and disease duration. None of the nail abnormalities, including leukonychia, had an association with distributionpattern of the disorder.Conclusion: Leukonychia was the most common abnormality in nails of vitiligo patients that had a relation to disease duration.
Hejazi Seyed Hossein; Makvandi Sanaz; Abedi Said; Soleimanifard Simindokht
Abstract
Background: Leishmaniasis is a parasitic disease originated from species of the genus Leishmania from the Trypanosomatidae family, with three main clinical forms of cutaneous, mucocutaneous and visceral. Every year, many new cases of the disease are reported in endemic areas. Nowadays, in non-endemic ...
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Background: Leishmaniasis is a parasitic disease originated from species of the genus Leishmania from the Trypanosomatidae family, with three main clinical forms of cutaneous, mucocutaneous and visceral. Every year, many new cases of the disease are reported in endemic areas. Nowadays, in non-endemic regions, the incidence of the disease has also created tension. Medicine side effects, reports of resistance against currently used drugs, and the absence of a putative vaccine have made researchers look for new effective drugs. The objective of the present study was to evaluate the effects of the ethanolic and aquatic extracts of the Ziziphora tenuior L. on the prolifration of Leishmania major amastigotes.
Methods: The J774 cell lines were infected by promastigotes, at stationary phase, and treated with different concentrations of both extracts. After 12, 24 and 48 hours (h) at 37°C, the macrophages were stained with Giemsa, and the mean number of amastigotes in the macrophages was determined and compared with the control group. Finally, the ED50 of the extracts was calculated through statistical analysis.
Results: Aquatic and ethanolic extracts of Ziziphora tenuior L. reduced the number of amastigotes within the macrophages. Following 48h of treatment, the ED50 of the aquatic and ethanolic extracts of the plant were 15.75 mg/ml and 15 mg/ml, respectively. Hence, there was no significant difference between the ED50 of the aquatic and ethanolic extracts of the plant P<0.05).
Conclusion: Aquatic and ethanolic extracts of Ziziphora tenuior L. have a considerable anti Leishmania effect, hence the significance of further studies using the animal model of CL.
H Edalat Khah; F Amani; G Rezaifar
Volume 7, Issue 2 , 2004, , Pages 72-77
Abstract
Background: Melasma is a pattern of facial pigmentation that affects upper lip, cheeks, forehead and chin. The disease is seen mainly in 30-55 year old women, and may be regarded as a physiological change in pregnancy. Its etiologic nature is still unknown. Objective: To determine the prevalence of melasma ...
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Background: Melasma is a pattern of facial pigmentation that affects upper lip, cheeks, forehead and chin. The disease is seen mainly in 30-55 year old women, and may be regarded as a physiological change in pregnancy. Its etiologic nature is still unknown. Objective: To determine the prevalence of melasma in women in Ardebil city. Patients and Methods: The study was cross sectional-descriptive study done on 855 women in Ardebil city in 2002. Sampling method was cluster and 855 women in the age range of 12-85 years in 25 health services (From each family one woman over 11 years) were randomly selected and necessary information have been collected by a questionnaire. Descriptive and analytic statistics were used to analyze data in SPSS program. Results: The prevalence of melasma among total participants was 39.5% and 9.5% of melasma cases were pregnant women. The distribution of hyperpigmentation was mainly centrofacial (64.7%), and in 40.8% cases there was a positive familial history for melasma. Conclusion: Melasma is a common disease in Ardebil, and abundant search is necessary to understand the etiology and treatment of this disease.
Paria Baharvand; Ayda Esmaeili; Mohammad Reza Abbasi; Soha Namazi
Abstract
Background: The 12-Item Pruritus Severity Scale (12-PSS) is a multidimensional tool that evaluates pruritus intensity and duration along with an assessment of psychometric properties such as the patient´s mood, daily activities, and sleep pattern. Given its chronicity, uremic pruritus has a substantial ...
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Background: The 12-Item Pruritus Severity Scale (12-PSS) is a multidimensional tool that evaluates pruritus intensity and duration along with an assessment of psychometric properties such as the patient´s mood, daily activities, and sleep pattern. Given its chronicity, uremic pruritus has a substantial impact on quality of life, so it is worth having a valid Persian questionnaire for assessing the various aspects of pruritus. This study was designed to evaluate the validity and reliability of the translated 12-PSS in hemodialysis patients with chronic uremic pruritus.
Methods: Participants in this cross-sectional study were hemodialysis patients with uremic pruritus who were referredto the dialysis departments of three hospitals in Tehran, Iran. Following forward-backward translation of the 12-PSS to and from Persian, we assessed its content validity index (CVI) and reliability. Finally, we asked patients to respond to questions using both the Visual Analog Scale (VAS) and the 12-PSS.
Results: Overall, 195 eligible patients participated in this study. The average age was 55.08 ± 12.34 years. The internalconsistency (Cronbach’s alpha) of the 12-PSS was found to be 0.88, indicating strong consistency. The mean VAS and 12-PSS scores were 6.40 ± 2.63 and 11.52 ± 3.91, respectively, and the correlation between VAS and the total raw points of the pruritus intensity domain of the 12-PSS (questions 9 and 10) was strong(P-value < 0.05, r = 0. 90).
Conclusions: This study showed that the translated form of the 12-PSS questionnaire has acceptable validity and reliability and has a strong correlation with the VAS in assessing pruritus intensity.
Amirhooshang Ehsani; Pedram Noormohammadpour; Kamran Balighi; Narges Ghandi; Parisa Dabirvaziri; Sahar Azizahari
Volume 12, Issue 3 , 2009, , Pages 74-78
Abstract
Background: Ingrown toe nail (IGTN) is a painful condition in which the distal-lateral corner of the nail grows into its surrounding soft tissue leading to inflammation and infection. Failure of conservative therapy is an indication for surgical interventions. The aim of this study is to compare matricectomy ...
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Background: Ingrown toe nail (IGTN) is a painful condition in which the distal-lateral corner of the nail grows into its surrounding soft tissue leading to inflammation and infection. Failure of conservative therapy is an indication for surgical interventions. The aim of this study is to compare matricectomy by curettage with chemical matricectomy with phenol 88% in terms of post procedure remission and complications.Methods: A number of 18 patients with IGTN were selected and divided randomly into 9-subject groups. The first group underwent matricectomy by curettage and the second underwent chemical matricectomy with phenol 88%. Patients were assessed after 2, 7 days and 1, 4 months after surgery for pain, oozing, soft tissue inflammation, cellulitis or purulent discharge and recurrence in both of the groups and the results were statistically compared.Results: On the third post procedure day, pain and oozing discharge occurred less in curettage group with significant difference (P = 0.016 and 0.009). In our next visit, one week after procedure, there was no significant difference in recovery and post procedure complications (P = 0.475). In our visit, 4 weeks after procedure, all cases in both groups were completely healed for all parameters and no complication was found.Conclusion: Curettage partial matricectomy is superior to phenol matricectomy in achieving earlier release of post procedure symptoms and complete recovery.
Firooz Alireza; Hallaji Zahra; Khatami Alireza; Lajevardi Vahideh; Mansouri Parvin; Pedram Mehryan; Zohreh Mozafari; Mansour Nassiri-Kashani; Reza Robati; Hassan Seirafi
Volume 18, Issue 3 , 2015, , Pages 81-96
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.One of the missions of the Iranian ...
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Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.One of the missions of the Iranian Society of Dermatology is to develop strategies in order to provide the best possible management for patients suffering from dermatological conditions. To accomplish this mission, the Society assigned a committee to search and critically appraise the recent research evidence and available guidelines to develop a clinical practice guideline concerning diagnosis and treatment of urticaria.
Yalda Nahidi; Naser Tayyebi Meibodi; Habibollah Esmaili
Volume 17, Issue 3 , 2014, , Pages 81-84
Abstract
Background: Vitiligo is a common cutaneous depigmentation disorder caused by the destruction of melanocytes. The exact etiopathogenesis of this disorder is not well known, but a complex of genetic, immunologic, inflammatory, and cytotoxic factors have been implicated. According to ...
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Background: Vitiligo is a common cutaneous depigmentation disorder caused by the destruction of melanocytes. The exact etiopathogenesis of this disorder is not well known, but a complex of genetic, immunologic, inflammatory, and cytotoxic factors have been implicated. According to reports on the role of vitamin B12 and folic acid deficiency as important co-factors in the metabolism of homocysteine, we expected an increase in homocysteine levels in patients with vitiligo; therefore, our aim was to investigate the serum levels of homocysteine in Iranianpatients with vitiligo.Method: Forty patients with vitiligo and 40 healthy controls matched for age and sex were studied. After exclusion of cases with diseases that could affect the homocysteine level, serum homocysteine levels were measured by ELISA.Result: Males comprised 57.5% of the participants in both groups and 42.5% were female. The mean age of the patients was 24.68 ± 12.44 years. The level of homocysteine in the case andcontrol groups was 18.56 ± 5.69 and 10.19 ± 4.40, respectively, which was significantly higher in patients with vitiligo (P ? 0.001). There was no correlation between homocysteine levels and age,sex, history of previous treatment, duration of disease, and the extent of body surface involvement. Serum homocysteine levels in patients with regressive vitiligo (13.8) were lower thanprogressive (18.4) and stable (20.4) cases (P = 0.05).Conclusion: We found that the increase in serum homocysteine level in patients genetically susceptible to vitiligo could be a predisposing factor for the development of vitiligo. The serumhomocysteine level is associated with disease activity, and may be used as a prognostic factor for disease activity.
Saeedeh Farajzadeh; Soodabeh Zandi; Mohammad Mehdi Hayatbaksh Abbasi; Fahimeh Gadari; Armita Shahesmaeili; Behrooz Vares; Golamreza Hosseinpour; Iman Shojaei Baghini
Volume 14, Issue 3 , 2011, , Pages 81-85
Abstract
Background: The association between coronary artery disease and androgenic alopecia has been demonstrated, but few studies have focused on the mechanism of this association. The aim of this study was to evaluate the lipid profile in male pattern alopecia.Methods: In this case control study, 45 male patients ...
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Background: The association between coronary artery disease and androgenic alopecia has been demonstrated, but few studies have focused on the mechanism of this association. The aim of this study was to evaluate the lipid profile in male pattern alopecia.Methods: In this case control study, 45 male patients with androgenic alopecia who were aged from 20 to 50 years and 45 men with a normal hair status aged from 20 to 50 years were enrolled as the case and control groups, respectively. Lipid parameters including cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, lipoprotein (a), apolipoprotein A1, apolipoprotein B were measured in cases and controls.Results: A significant difference in serum lipoprotein (a) was observed between case and control groups (p< 0.001). We noted that 47.1 percent of the patients and 17.96% of the controls had a lipoprotein (a) level more than 30 mg/dl which is a critical level for coronary artery disease. There was no significant difference in other lipid parameters between two groups. The family history of androgenic alopecia and coronary heart disease was significantly higher in the cases than the controls.Conclusion: Considering the results of the study and the important role of lipoprotein (a) as a risk factor for atherosclerotic heart disease, we suggest that all men with a male pattern hair loss should be investigated for lipid indices, especially lipoprotein (a).
Abbasi Ali; Toossi Parviz; Shakoei Safoura; Abolhasani Ehsan; Younespour Shima
Volume 16, Issue 3 , 2013, , Pages 83-88
Abstract
Background: Different modalities have been tried in order totreat stable vitiligo. Culturing melanocytes is time consumingand expensive. Therefore, new methods using autologousmelanocytes are sought. We aimed to compare the mixed nonculturedautologous melanocytes of the outer root sheath andthe bulge ...
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Background: Different modalities have been tried in order totreat stable vitiligo. Culturing melanocytes is time consumingand expensive. Therefore, new methods using autologousmelanocytes are sought. We aimed to compare the mixed nonculturedautologous melanocytes of the outer root sheath andthe bulge area of hair follicle transplantation plus dermabrasionwith dermabrasion alone in stable generalized vitiligo patchesrepigmentation.Method: Eight patients with stable generalized vitiligo wererecruited. Two patches were selected and assigned to one of thestudy groups: one was treated with dermabrasion alone, andthe other was treated with dermabrasion and transplantation.Uncultured melanocytes were extracted from the patients’ hairfollicle outer root sheath and bulge. The patches were assessedmonthly for the next six months. The primary outcome was todetermine the percentage changes of the depigmented patchesfrom the baseline.Result: Although the repigmentation changes were statisticallysignificant in transplantation patches, there was only one patchwith good and another with fair pigmentation. Furthermore,seven patches without and one patch with poor pigmentationwere observed as control lesions. The transplanted patchesdemonstrated a significantly better repigmentation rate in contrastto their controls (p=0.03).Conclusion: Although this method is fast and economic, theclinical response was not satisfactory.
Ghazal Shariatpanahi; Rezvan Hashemi; Mahsa Asadabadi; Nava Shirzadi; Nazgol Sadat Haddadi; Safoura Shakoei
Abstract
Background: Acne is a common chronic inflammatory skin disease predominantly occurring during adolescence; this condition adversely affects a person’s self-esteem and can be associated with metabolic disorders. This study aimed to investigate the prevalence of metabolic syndrome and its components ...
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Background: Acne is a common chronic inflammatory skin disease predominantly occurring during adolescence; this condition adversely affects a person’s self-esteem and can be associated with metabolic disorders. This study aimed to investigate the prevalence of metabolic syndrome and its components in adolescent girls with acne compared to a control group. Materials and Methods: In this cross-sectional study,105 adolescent girls aged 12-18 years were assigned to either the acne (case; n=55) or control group (n=50). The case group was selected from the Dermatology Department of a general hospital in Tehran, Iran, between January and August 2017. Acne lesions were confirmed and graded by a dermatologist. Clinical and biochemical parameters were evaluated for all participants. Results: The prevalence of metabolic syndrome in patients with and without acne was 18.2% and 14%, respectively. As a result, metabolic syndrome was not correlated with acne in adolescent girls (P=0.561). In addition, the mean body mass index (P=0.89), waist circumference (P=0.62), mean systolic and diastolic blood pressures (P=0.57 and 0.62, respectively), fasting blood sugar (P=0.59), total cholesterol, and low-density lipoprotein cholesterol levels were comparable between the studied groups (P>0.05). Moreover, triglyceride levels were significantly lower in the acne group (P=0.028), whereas this group featured a higher level of high-density lipoprotein cholesterol (P=0.02). However, the logistic regression results showed that none of the measured lipids were associated with acne. Conclusion: The findings indicated that metabolic syndrome and its components (representing metabolic imbalance) were not correlated with acne in adolescent girls.
