Golnaz Mehran; Saba Sepasgozar; Masoomeh Rohaninasab; Azadeh Goodarzi; Mohammadreza Ghassemi; Mahrokh Fotooei; Elham Behrangi
Abstract
Background: Microneedling has been shown to be a clinically effective and safe treatment for comedonal acne vulgaris. The aim of the present study was to compare the clinical effectof microneedling and the most commonly used topical drug, tretinoin, in the treatment of comedonal acne.Methods: ...
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Background: Microneedling has been shown to be a clinically effective and safe treatment for comedonal acne vulgaris. The aim of the present study was to compare the clinical effectof microneedling and the most commonly used topical drug, tretinoin, in the treatment of comedonal acne.Methods: Patients with comedonal acne (n = 82) were randomized to receive topical tretinoin (n = 41) or 6 sessions of microneedling (n = 41) over a period of 3 months. Objective assessments suchas changes in acne severity score by global acne grading system (GAGS) and patients’ subjective satisfaction were investigated at the baseline, at the end of the treatment period, and at the3-month follow up.Results: GAGS was significantly reduced in both microneedling (7.8±3.8 to 3.5±2.6) and tretinoin (8±3.8 to 6.6±3.2) groups at the end of the treatment course compared with the baseline. Theoverall acne severity index reduction in microneedling group was significantly higher than that of the tretinoin group (P<0.001). Improvement in acne severity was also more permanent bymicroneedling. The severity of acne in tretinoin recipients was increased to 8.2±3.2 at the follow-up visit, while it remained nearly unchanged in the microneedling group. (3.3±2.4). Patients’subjective assessment concerning acne improvement was significantly more satisfactory in microneedling group (P<0.001).
Conclusion: Compared with tretinoin, microneedling seems to be a more effective, permanent and satisfactory treatment in the treatment of comedonal acne.
Farnaghi Farshad; Seirafi Hassan; Ehsani Amirhooshang; Tork Ali Naser; Yazdanian Shideh; Zarrin-nejad Neda
Volume 10, Issue 2 , 2007, , Pages 94-99
Abstract
Background and aim: Treatment of resistant warts is a common clinical problem. Immunotherapy with diphenyl cyclopropenone (DCP) as a contact sensitizer has been reported. The objective of this study was to evaluate the efficacy of DCP in refractory warts.Materials and methods: Nineteen patients with ...
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Background and aim: Treatment of resistant warts is a common clinical problem. Immunotherapy with diphenyl cyclopropenone (DCP) as a contact sensitizer has been reported. The objective of this study was to evaluate the efficacy of DCP in refractory warts.Materials and methods: Nineteen patients with refractory warts referred to Razi Hospital in 2004 who had not responded to at least 2 treatment modalities, were sensitized with 2% DCP in acetone.Then treatment was started with application of 1% DCP on plantar warts and 0.2% on other locations.Results: Two patients were not sensitized even after 3 attempts. Three other patients discontinuedtreatment due to side effects (severe eczema and pruritus). Six male and 8 female patients completed the trial, among them,10 (71.5%) showed complete clearance of warts. Side effects reported were: local pruritus (21%), distant eczema (10.5%), local blister (26.3%). The patients received a mean of 5 treatment sessions.Conclusion: Topical immunotherapy with DCP is an effective treatment for refractory warts. Due to high efficacy, no scarring, and being a painless procedure it can be considered as a first line treatment of refractory warts.
Muhammad Munir Rashid; Uzire Azam Khan; Md Akramullah Sikder; Eakub Ali; Nargis Akhtar
Volume 11, Issue 3 , 2008, , Pages 99-102
Abstract
Background: Lichen planus is a common dermatological condition. Many treatment options have been discussed in literature, each with its own risk profile. Betamethasone pulse therapy is one of the effective therapies mentioned.The objective of this study was to find out whether oral betamethasone mini ...
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Background: Lichen planus is a common dermatological condition. Many treatment options have been discussed in literature, each with its own risk profile. Betamethasone pulse therapy is one of the effective therapies mentioned.The objective of this study was to find out whether oral betamethasone mini pulse therapy is effective in lichen planus.Methods: A total of 40 patients were enrolled in the study. Twenty patients received 5mg of oral betamethasone daily for two consecutive days in a week for 6 weeks along with loratadine and the other twenty patients received a loratadine tablet daily for the same period.Results: The flattening of the existing lesions, appearance of the new lesions and persistence of itching were considered as the parameters of clinical evaluation. It was clearly observable that the number of lichen planus lesions were drastically decreasing in group A and only slightly increasing in group B during the follow-ups.Conclusion: Betamethasone oral mini-pulse therapy was found to be more effective than loratadine in the treatment of lichen planus.
Jatana Gurpoonam; Gupta Sunil Kumar; Kaushal Sandeep; Kajal Shobhna; Kaur Sandeep
Volume 20, Issue 4 , 2017, , Pages 103-112
Abstract
Background: Adverse cutaneous drug reactions are unwarranted effects of modern medicine. These unfortunate events can assume any morphology from simple exanthem to full blown toxic epidermal necrolysis (TEN), and can simulate and mimic many diseases. Sometimes it is difficult to recognize the cause, ...
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Background: Adverse cutaneous drug reactions are unwarranted effects of modern medicine. These unfortunate events can assume any morphology from simple exanthem to full blown toxic epidermal necrolysis (TEN), and can simulate and mimic many diseases. Sometimes it is difficult to recognize the cause, but they may be due to polypharmacy or self-administration of medications. The analytical data from this study might help us to see certain patterns with various drugs and shed light on this problem. We performed this study at a tertiary hospital in Punjab, Dayanand Medical College and Hospital (DMCH), in order to determine the clinical patterns of cutaneous manifestations of adverse drug reactions (ADR).Methods: The diagnosis was mainly based on detailed history and correlation between drug intake and the onset of rash along with laboratory investigations and skin biopsy results where possible. We assessed 695 patients (379 males and 316 females) who presented with cutaneous drug reactions over a 12-month period.Results: The most common benign ADR observed was exanthem, which affected 199 (28.64%) patients followed by acute urticaria, including angioedema, which was seen in 126 (18.13%) patients, and fixed drug eruption (FDE) in 105 (15.11%) that included bullous FDE reactions. Other reactions included Stevens-Johnson syndrome (SJS) and TEN in 39 (5.61%) patients, erythroderma in 27 (3.88%), hotosensitivity reactions, including phototoxic and photosensitive reactions, 31(4.46%), and lichenoid eruptions in 25(3.59%) patients.Conclusion: Exanthems were the most common drug eruptions observed. Antibiotics and NSAIDS were the most common causes for benign drug eruptions, whereas antiepileptics were a major cause of severe cutaneous adverse reactions (SCARs).
Jawade Sugat A.; Saigaonkar Vaidehi A.; Kondalkar Ambika R.
Volume 19, Issue 4 , 2016, , Pages 105-112
Abstract
Background: Topical retinoid based combinations are recommended to enhance the outcome of acne treatment. Adapalene-benzoyl peroxide (BPO) combination gel was approved in 2009 for acne treatment. The aim of this study was to evaluate the efficacy and tolerability of adapalene 0.1%-benzoyl peroxide 2.5% ...
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Background: Topical retinoid based combinations are recommended to enhance the outcome of acne treatment. Adapalene-benzoyl peroxide (BPO) combination gel was approved in 2009 for acne treatment. The aim of this study was to evaluate the efficacy and tolerability of adapalene 0.1%-benzoyl peroxide 2.5% combination gel compared to adapalene 0.1% gel monotherapy and benzoyl peroxide 2.5% gel monotherapy in treatment of acne vulgaris in Indian patients.Methods: A randomized, parallel group, investigator-blind clinical trial was conducted from September 2014 to September 2015 in the Dermatology outpatient department. The patients were randomized into three groups of adapalene 0.1% gel, benzoyl peroxide 2.5% gel, and adapalene 0.1%-benzoyl peroxide 2.5% combination gel. The patients were asked to apply the allocated gel to the face in the evening for 12 weeks. Efficacy was evaluated using percent of reduction in total, inflammatory, and non-inflammatory lesions and success rate while tolerability was assessed by evaluating skin dryness, erythema, stinging or burning sensation and scaling at baseline and 1, 2, 4, 8, and 12 weeks.Results: At the end of 12 weeks, the success rate reached 37.2% with adapalene-BPO combination gel compared to 23.3% and 19.4% for adapalene and benzoyl peroxide gel monotherapy respectively. Adapalene-BPO combination gel was significantly effective in the reduction of total, non-inflammatory and inflammatory lesions by 75.9%, 75.4%, and 74.7% respectively compared to the corresponding monotherapies. Side effects with adapalene–BPO combination gel were mild and transient.Conclusion: Adapalene–BPO combination gel was more efficacious and better tolerated than adapalene and benzoyl peroxide gel monotherapy.
Pouran Layegh; Hamid Reza Arshadi; Sara Shahriari; Fakhrolzaman Pezeshkpour; Yalda Nahidi
Volume 13, Issue 4 , 2010, , Pages 106-111
Abstract
Background: Due to their chronic nature, influences on the body image, hopelessness toward complete recovery and frequent recurrences, dermatological diseases seem to be one of the important predisposing factors in depression and suicidal ideation. Thus, the present study aimed at evaluating the degree ...
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Background: Due to their chronic nature, influences on the body image, hopelessness toward complete recovery and frequent recurrences, dermatological diseases seem to be one of the important predisposing factors in depression and suicidal ideation. Thus, the present study aimed at evaluating the degree of depression and suicidal ideation in patients with psoriasis, acne, alopecia areata and vitiligo.Methods: The study was carried out on 300 patients with psoriasis, acne, alopecia and vitiligo who were referred to the dermatology clinic of Ghaem Hospital in Mashad. Beck depression questionnaire was used to collect the data which was then statistically analyzed with ANOVA and T-test, using SPSS software.Results: In this study, 35.7% (107) of the subjects were female and 64.3% (193) were male with a mean age of 26.55±10.81 years. The prevalence rate of clinical depression was found to be 47.4% in patients with acne; 69.4% in those with psoriasis; 70.1% in those suffering from vitiligo; 50% in diffuse alopecia areata; 60% in universalis alopecia areata; 100% in ophiasis alopecia areata and 68.3% in patients with localized alopecia areata. As for suicidal ideation, there was no sign in 88.3% (265); however, 6.3% (19) of the patients reported to have thought of suicide but they had no desire for the attempt while 4% (12) of them had some desire for suicide and 1.3% (4) were seriously determined to commit suicide if only they would find themselves in an appropriate situation.Conclusion: As shown by the findings of the study, there was a close relationship between dermatological diseases and psychological factors; thus, it is important to immediately diagnose concurrent psychological effects, especially those of depression and suicidal ideation. We found that there was a significant relationship between the prevalence rate of dermatological conditions and psychological effects; i.e. depression (P=0.008) and suicidal ideation (P=0.001). We also found out that the rate of suicide attempt was highest among the patients with universalis alopecia, diffuse alopecia areata and vitiligo, respectively.
Tabari Soudabeh Tirgar; Moghadam Nia Ali Akbar; Hajian Karimollah; Moeinzadeh Amirmajid
Volume 12, Issue 4 , 2009, , Pages 106-110
Abstract
Introduction: Topical antimicrobials, such as clindamycin, are effective in the treatment of acne and azelaic acid, due to the lack of bacterial resistance, could be a useful alternative in topical treatment of acne. The aim of this study was to compare the effect of topical azelaic acid 20% with clindamycin ...
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Introduction: Topical antimicrobials, such as clindamycin, are effective in the treatment of acne and azelaic acid, due to the lack of bacterial resistance, could be a useful alternative in topical treatment of acne. The aim of this study was to compare the effect of topical azelaic acid 20% with clindamycin 1% lotion for the treatment of acne. Method: This randomized clinical trial study was performed on 108 patients with mild and moderate acne. Patient were randomly assigned to one of the two groups of treatment with azelaic acid 20% cream (50 patients) or clindamycin 1% lotion (58 patients). The patients were evaluated by grading and lesion counting methods before treatment and one month and two months after the treatment. Results: The mean age of the patients in clindamycin group and azalic acid was 19. 6±3. 9 and 20. 3±4. 5 years, respectively (P=0. 41). The mean score of acne severity decreased after treatment according to grading and lesion counting methods (P0. 05) Conclusion: Result showed that the azelaic acid 20% topical cream was as effective as clindamycin 1% lotion for treating mild to moderate acne.
Dehghani Leila; Khanjani Narges; Bahrampour Abbas
Volume 15, Issue 4 , 2012, , Pages 111-116
Abstract
Background: Skin cancers are the most common human cancers.The most common skin cancers are basal cell carcinoma, squamouscell carcinoma and malignant melanoma. Different factors areinvolved in development of skin cancers; the most notable oneis exposure to ultraviolet radiation. In this study, the incidenceof ...
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Background: Skin cancers are the most common human cancers.The most common skin cancers are basal cell carcinoma, squamouscell carcinoma and malignant melanoma. Different factors areinvolved in development of skin cancers; the most notable oneis exposure to ultraviolet radiation. In this study, the incidenceof skin cancer was determined in Kerman province where islocated in the desert region of Iran with ample sunlight, duringa 5–year period.Method: All registered cases of skin cancers between March2005 and March 2010 were retrieved from the Kerman ProvinceCancer Registry. For each patient, data about age, gender,location, pathologic type of cancer and site of skin involvement,were obtained. Incidence rates according to the age, sex and thelocation of the lesions were calculated. Trend analysis was donefor the next 10 years.Result: During these 5 years, 1250 cases of skin cancer wererecorded. The incidence in men was 1.2 times higher than women.The highest incidence was seen in individulas older than 80 yearsof age. Fifty percent of all skin cancers were located on the face.The highest incidence was observed in the city of Kerman withan annual incidence of 12.6 in 100,000. Trend analysis showedthat the incidence of skin cancer in Kerman province would reach23 in 100 000 people in 2019, which is 2.3 times higher than theincidence rate in 2009.Conclusion: Skin cancer is a public health concern in Kermanprovince in Iran. Considering the desert climate and the intensity ofsunlight in most seasons, it is necessary to plan scientific practicalinterventions to prevent skin cancer and reduce its incidence..
Y Panahi; SM Davoudi; S Keshavarz; R Sarhang Nejad; A Tajic; MM Naghi Zadeh
Volume 9, Issue 2 , 2006, , Pages 114-121
Abstract
Background and aim: Chronic skin lesions are common late complications of sulfur mustard intoxication which would result in numerous complaints including pruritus, skin dryness and burn feeling. In chemical warfare injured veterans, pruritus is the most common complaint in chronic status with significant ...
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Background and aim: Chronic skin lesions are common late complications of sulfur mustard intoxication which would result in numerous complaints including pruritus, skin dryness and burn feeling. In chemical warfare injured veterans, pruritus is the most common complaint in chronic status with significant effects on patient's quality of life. This study has evaluated efficacy of topical phenol 1% and menthol 1% combination in treatment of pruritus in chemical warfare injured veterans in comparison with placebo.Materials and Methods: This randomized double blind clinical trial was done on chemical warfare injured veterans with mustard gas induced pruritus. Eighty patients were randomly divided to 2 equal groups, one group treated with phenol 1% and menthol 1% combination and other group with placebo for 6 weeks and the therapeutic effects were evaluated according to pruritus scores.Results: Pruritus score was significantly reduced in active group compared to placebo group (P=0.026).Conclusion: Phenol 1% and menthol 1% combination has significant therapeutic effect for mustard gas induced pruritus in chemical warfare injured veterans.
Hussain Sajjad; Hassan Iffat; Majeed Sabiya; Showkat A Bhat; Hinah Altaf; Peerzada Sajad
Volume 17, Issue 4 , 2014, , Pages 117-121
Abstract
Background: Psoriasis is a chronic inflammatory disease of theskin. The etiology of psoriasis is not known exactly. Recently, ithas been suggested that an imbalance in the oxidant- antioxidantstatus due to an increased reactive oxygen species production and/or deficient function of the antioxidant system ...
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Background: Psoriasis is a chronic inflammatory disease of theskin. The etiology of psoriasis is not known exactly. Recently, ithas been suggested that an imbalance in the oxidant- antioxidantstatus due to an increased reactive oxygen species production and/or deficient function of the antioxidant system may be involvedin the pathogenesis of psoriasis. The aim of this study was toevaluate the antioxidant defense status in patients with psoriasisand to look for a correlation, if any, between the antioxidantdefense status and the severity of psoriasis.Method: Sixty patients with psoriasis and an equal number ofage and sex matched healthy controls were enrolled in the study.Plasma levels of malondialdehyde (MDA), reduced glutathione(GSH), and superoxide dismutase (SOD), and antioxidant potential(AOP) were measured in cases as well as controls.Result: Patients with psoriasis were found to have significantlyhigher levels of plasma SOD (P < 0.001) and MDA (P < 0.001)and lower levels of GSH (P < 0.001) than controls. Plasma AOPwas not significantly different between patients and controls(P= 0.822).Conclusion: The results of our study support the hypothesisof an imbalance in the oxidant –antioxidant status in psoriasis,which could contribute to the pathogenesis of psoriasis.
Tazval Jafar; Ghaffari Mohtasham; Robati Reza M
Volume 16, Issue 4 , 2013, , Pages 121-127
Abstract
Background: Skin cancers are among the most prevalent malignancies in Iran. According to statistics, it is the most common cancer in the population of Ilam, west of Iran. The present study aimed to assess threat appraisal of skin cancer among rural farmers of Ilam in 2013-2014.Method: In this cross-sectional ...
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Background: Skin cancers are among the most prevalent malignancies in Iran. According to statistics, it is the most common cancer in the population of Ilam, west of Iran. The present study aimed to assess threat appraisal of skin cancer among rural farmers of Ilam in 2013-2014.Method: In this cross-sectional study, we used multistage random sampling. We collected the data through distribution of a researcher-developed questionnaire among 248 farmers from the rural areas of Ilam in June 2013. The items of the questionnaire were based on the protection motivation theory, and covered components included perceived vulnerability, perceived severity, and rewards. Result: We found a generally lower perceived vulnerability and severity and higher rewards among the farmers; 14.5 and 30.6 % of the farmers displayed higher perceived vulne
Mahsa Ghajarzadeh; Shahrbanoo Kheirkhah; Maryam Ghiasi; Nastaran Hoseini
Volume 14, Issue 4 , 2011, , Pages 123-128
Abstract
ackground: Psoriasis is a chronic hyperproliferative disease of the skin, scalp, nails, and joints that affects 2% of the general population. One of the extracutaneous manifestations of psoriasis is psoriatic arthritis which occurs in 25–34% of the psoriasis cases. This type of inflammatory arthritis ...
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ackground: Psoriasis is a chronic hyperproliferative disease of the skin, scalp, nails, and joints that affects 2% of the general population. One of the extracutaneous manifestations of psoriasis is psoriatic arthritis which occurs in 25–34% of the psoriasis cases. This type of inflammatory arthritis is characterized by pain, swelling, and tenderness around the joints, and may adversely affect patient’s functional abilities and the quality of life.Objectives: To evaluate depression and quality of life in Iranian patients with psoriasis and psoriatic arthritis.Materials and methods: From January 2009 to January 2010, 100 psoriasis patients who were randomly selected (through simple random selection) from the outpatient clinic of Razi Hospital and did not have any other skin or autoimmune diseases were asked to answer valid and reliable instruments such as the Beck Depression Inventory (BDI), SF-36, and DLQI (Dermatology Life Quality Index).Results: Mean scores of the BDI, SF-36, and DLQI of all the patients were 17.1 ± 12.3, 59.8 ± 19.5, and 12.4 ± 6.1, respectively. The most common type of the disease was the plaque type in eighty eight cases. Thirty-one women and 26 men were depressed (P = 0.06), and depressed individuals had higher DLQI scores (14.2 ± 5.5 vs. 9.9 ± 6.2, r = 0.3 P = 0.001). Patients with arthritis had significantly higher BDI and lower SF-36 scores suggesting more severe depression and quality of life impairment than those without arthritis.Conclusions: Extracutaneous manifestations of psoriasis and mood disorders should be considered in psoriatic patients to address the risk of markedly impaired quality of life.
Yalda Nahidi; Naser Tayyebi Meibodi; Amir Hossein Jafarian; Habibollah Esmaily; Elham Pishnamaz
Abstract
Background: Radiation-induced basal cell carcinoma (BCC) can be multiple, large, and recurring, which complicates its treatment in some cases. According to reports on the role of cyclooxygenase 2 (COX2) inhibitors in the treatment or prevention of non-melanoma skin cancers and considering ...
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Background: Radiation-induced basal cell carcinoma (BCC) can be multiple, large, and recurring, which complicates its treatment in some cases. According to reports on the role of cyclooxygenase 2 (COX2) inhibitors in the treatment or prevention of non-melanoma skin cancers and considering the fact that COX2 expression has not been evaluated in radiation-induced basal cell carcinoma, weset out to assess the expression of COX2 in these lesions. Methods: In this study, COX2 expression was assessed by immunohistochemistry using anti-COX2 antibody on paraffinembedded blocks of 86 patients referred to Emam Reza Hospitalin Mashhad with BCC diagnosis by pathological examination (43 patients with and 43 without a history of radiotherapy) followed by semi-quantitative evaluation of COX2. Results: In our study, COX2 expression score was significantly higher in patients with a history of radiotherapy than those without radiotherapy (P<0.001). No correlation was found between theintensity and percentage of staining with sex, age, site of lesion, recurrence, and pathology of the tumor. Conclusion: Given the higher expression level of COX2 in the radiation-induced BCC patients, the use of COX2 inhibitors in these individuals may be effective in the incidence, recurrence, or treatment of BCC.
MA Nilforoush Zadeh; F Jaffari; B Malek Afzali
Volume 7, Issue 3 , 2004, , Pages 136-139
Abstract
Background: In spite of different methods of treatment, there is not a simple, safe and complete curative treatment for cutaneous Leishmaniasis (CL), yet. Objective: To compare the efficacy of intralesional Glucantime injection alone, with the combined triple therapy of cryotherapy, paramomycin ointment ...
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Background: In spite of different methods of treatment, there is not a simple, safe and complete curative treatment for cutaneous Leishmaniasis (CL), yet. Objective: To compare the efficacy of intralesional Glucantime injection alone, with the combined triple therapy of cryotherapy, paramomycin ointment and intralesional Glucantime in the treatment of CL. Materials and methods: 157 patients with CL were randomly allocated into 2 groups, 81 patients in group 1 were injected with intralesional Glucantime (Twice a week up to healing to the lesions or maximum 6 weeks). 76 patients in group 2 were treated with Paramomycin ointment (15% in 10% urea, twice a day), cryotherapy (Maximum 3 times 2 weeks) apart and injection of intralesional Glucantime (Once a week), for the same period as group 1. Results: After 6 weeks, complete cure rate in group 2 (89.5%) was significantly more than group 1 (70.4%) (P<0.05). Conclusion: Our results indicating of more efficacy of the triple therapy is in accordance with the previous studies of combined cryotherapy and Paramomycin. It could be recommended as a better treatment modality for CL wherever possible.
Ghodsi Seyyede Zahra; Bahar Babak; Balighi Kamran; Ranjkesh Mohammad Reza; Toosi Siavash
Volume 11, Issue 4 , 2008, , Pages 137-142
Abstract
Background: Chronic graft versus host disease (ch.GVHD) is the most frequent late complication after allogenic stem-cell transplantation. Systemic immunosuppressive agents are usually required to control the disease. Psoralen plus UVA (PUVA) has been used for the treatment of ch.GVHD with variable beneficial ...
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Background: Chronic graft versus host disease (ch.GVHD) is the most frequent late complication after allogenic stem-cell transplantation. Systemic immunosuppressive agents are usually required to control the disease. Psoralen plus UVA (PUVA) has been used for the treatment of ch.GVHD with variable beneficial effects. The objective of this study was to assess the efficacy and safety of a relatively lower dose of oral psoralen compared with previous reports, for the treatment of ch.GVHD patients with PUVA.Methods: Eleven patients who received allogenic bone marrow transplantation and had severe progressive ch.GVHD that was unresponsive to conventional immunosuppressive treatments were treated with oral 8-methoxypsoralen (0.2 mg/kg, up to 10 mg) two hours before exposure to UVA.Results: The patients received a median of 43 treatments (range: 18 to 72). Mean cumulative dose of UVA was 200.5 J/cm2 (range, 116.5-306.5 J/cm2). In four of the 11 patients, there was a complete resolution of cutaneous ch.GVHD and the remaining seven patients achieved partial response with PUVA treatment. Complete and partial remission was observed in four and six patients with lichenoid lesions, respectively, but all of the four patients with sclerodermoid GVHD showed partial response to PUVA treatment. We observed no side effects like phototoxicity, nausea and vomiting, and exacerbation of GVHD. Liver enzymes raised in five patients, causing no significant morbidity for them.Conclusion: Low-dose psoralen plus UVA can be a safe and effective therapy for chronic cutaneous GVHD. Although the number of treatments and total cumulative exposure to UVA was rather high in our study, we observed no phototoxic reaction or severe irreversible liver damage due to phototherapy, which may be because of a relatively lower dose of methoxsalen used in our patients. Psoralen plus UVA is effective particularly in lichenoid GVHD lesions but sclerodermoid lesions may also benefit from this therapy.
Nasrollahi Saman Ahmad; Hasanzadeh Hournaz; Ajami Marjan; Ameri Setareh; Variji Zeinab; Komeili Ali; Firooz Alireza
Volume 18, Issue 4 , 2015, , Pages 145-150
Abstract
Background: Cellulite is a common disease whose exact mechanism is unknown. This study was aimed to assess the safety and efficacy of an anti-cellulite preparation compared with placebo in a randomized double-blind, right-left comparison clinical trial.Methods: Twelve healthy women aged 22 to 58 years ...
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Background: Cellulite is a common disease whose exact mechanism is unknown. This study was aimed to assess the safety and efficacy of an anti-cellulite preparation compared with placebo in a randomized double-blind, right-left comparison clinical trial.Methods: Twelve healthy women aged 22 to 58 years with mild to moderate cellulite on their thighs and buttocks participated in this trial. The anti-cellulite preparation (Three O cream, Pouya Varzan Tejarat Sepahan Co., Iran) and an identical placebo were randomly applied on the right or left thigh and buttock twice a day for 2 months. The mentioned areas were photographed and the circumference, subcutaneous fat thickness, and dermis density and thickness were measured before and after treatment. A satisfaction questionnaire was completed by all volunteers to assess their satisfaction with the efficacy of treatment on each side.Results: There was no significant difference between active and placebo treatment sides in any of measurements. About 90% of participants had an overall satisfaction of 5 and more than 5 based on a 0 to 10 visual analogue scale on the side of anti-cellulite cream. This score was similar on the sides treated with placebo and the active product.Conclusion: Although Three O cream provided more satisfaction in volunteers than placebo, the objective measurements did not show any difference between them.
Amirhoushang Ehsani; Alireza Firooz; Arezou Jam Manesh; Amirali Jahanshahi; Elnaz Khosravani; vahide Lajevardi; Parvin Mansouri; Mansour Nassiri Kashani; Reza M Robati; Zahra Saffarian
Abstract
Urticaria is a frequent and difficult-to-treat skin condition, described as temporary erythematous, raised, and itchy skin lesions (wheals) brought on by dilated blood vessels, elevated local blood flow, and increased vascular permeability. It can occur alone or in conjunction with angioedema. Urticaria ...
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Urticaria is a frequent and difficult-to-treat skin condition, described as temporary erythematous, raised, and itchy skin lesions (wheals) brought on by dilated blood vessels, elevated local blood flow, and increased vascular permeability. It can occur alone or in conjunction with angioedema. Urticaria can be diagnosed and treated in fields other than dermatology; patients often visit general physicians, internal medicine specialists, allergologists, and clinical immunologists. In 2018, the Iranian Society of Dermatology produced a clinical practice guideline on diagnosing and managing urticaria. To update the guideline, the Guideline Development Committee conducted an exhaustive search of scientific papers published on the topic from April 2018 to the end of August 2022, and the new guideline was developed. Finally, the updated guideline was critiqued by members of the Dermatology Board Certificate Examination Panel and chairs of dermatology departments in Iran, and it was improved using their feedback.
SM Davoudi; AA Karimi Zarchi; S Ghafouri Manesh; AR Firooz; M Nasiri Kashani; Y Dowlati
Volume 8, Issue 3 , 2005, , Pages 166-170
Abstract
Background: Eczema is one of the most widely spread inflammatory skin disorders contact dermatitis is an eczematous dermatitis that is produced as a result of contact with a substance in the environment. The substance can act as an irritant or allergen. Every country has allergen particular to itself. ...
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Background: Eczema is one of the most widely spread inflammatory skin disorders contact dermatitis is an eczematous dermatitis that is produced as a result of contact with a substance in the environment. The substance can act as an irritant or allergen. Every country has allergen particular to itself. Objective: Determining the frequency of skin allergens in patients with contact dermatitis in Tehran. Patients and Methods: In this cross-sectional descriptive study, all the data about the patients with chronic contact dermatitis who were visited in a dermatology clinic in Tehran from the year 1993 to 2003 and patch tested with 23 allergens of European standard series (ESS) were analyzed. Results: In this study 222 patients were surveyed. The mean age of the patients was 33.5 years (SD=13.8). 66.5% of the patients were female. The most common site of involvement (49%) was their hands. The mean duration of the disease was 54 months (SD=62). Clinical diagnosis included: 59% allergic contact dermatitis, 24% irritant dermatitis, 10% atopic dermatitis, and 7% other types of dermatitis. 145 (65.3%) of them had at least one positive reaction. The most common allergens were: Nickle sulfate 22.6%, cobalt chloride 14.5%, and fragrance mix 13.6%. Conclusion: Nickel was the most common contact allergen among the patients surveyed.
Layeh Pouran; Pezeshkpour Fakhr-o-Zaman; Shakeri Mohammad Taghi; Mousavi Sareh
Volume 10, Issue 3 , 2007, , Pages 174-180
Abstract
Background and aim : Genital wart is a common sexually transmitted disease caused by different types of human papilloma virus (HPV). Cryotherapy is one of the most commonly used treatment options. Trichloroacetic acid (TCA) is another therapy commonly used in treatment of genital warts.Materials and ...
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Background and aim : Genital wart is a common sexually transmitted disease caused by different types of human papilloma virus (HPV). Cryotherapy is one of the most commonly used treatment options. Trichloroacetic acid (TCA) is another therapy commonly used in treatment of genital warts.Materials and methods: The objective of his study was to evaluate and compare the efficacy and adverse effects of TCA and cryotherapy (with liquid nitrogen). Sixty female patients with external genital warts were enrolled into this prospective clinical trial. Thirty of them received topical solution of 80% TCA and the other 30 received cryotherapy with liquid nitrogen, once a week, until complete clearance of lesions or a maximum duration of 8 weeks. Results: Twenty-seven patients (93.1%) of those who received up to eight treatments of cryotherapy had complete clearance of their warts, compared with 28 (96.5%) of patients who were treated with TCA (P>0.05). The mean duration for complete clearance was 4.4 weeks for TCA and 5.2 weeks for cryotherapy (P=0.5). Patients who received TCA experienced a significantly greater number of local inflammatory reactions (P=0.01). Conclusion: Both cryotherapy and TCA are effective treatments. In comparison, TCA showed its efficacy earlier during the course compared to cryotherapy. TCA is more likely to cause adverse reactions.
Z Hallaji; Sh Shams Davatchi; M Vali Khani; N Ghandi; M Kar Bakhsh Davari; M Hedayati; AR Firooz
Volume 9, Issue 3 , 2006, , Pages 204-210
Abstract
Background and aim: Azathioprine is the most widely used immunosuppressive agent as an adjunct to corticosteroids in the treatment of pemphigus vulgaris (PV). Thiopurine methyl transferase (TPMT) is a key enzyme in azathioprine metabolism and a genetic polymorphism controls its activity in human tissue. ...
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Background and aim: Azathioprine is the most widely used immunosuppressive agent as an adjunct to corticosteroids in the treatment of pemphigus vulgaris (PV). Thiopurine methyl transferase (TPMT) is a key enzyme in azathioprine metabolism and a genetic polymorphism controls its activity in human tissue. TPMT activity can provide a rational basis to determine suitable dose of azathioprine, theoretically. The aim of this study was to evaluate the clinical relevancy of this hypothesis in PV patients.Materials and Methods: In this cross sectional study in Razi Hospital, the activity of TPMT in the red blood cells of 52 PV patients who received azathioprine for at least 12 months and 29 PV patients who did not receive this drug was measured and correlated to the clinical response and side effects observed.Results:The mean of TPMT activity was not significantly different in patients with unfavourable response, comparing to patients with favorable response to azathioprine (P=0.087). No relationship was observed between total dose of corticosteroid and TPMT activity (r=0.089, P=0.583). There was no difference between the mean of TPMT activity in patients receiving azathioprine and those not receiving this drug (P=0.36).Conclusion: A direct relationship was not observed between TPMT activity and clinical efficacy and side effects in PV patients under treatment with azathioprine. Larger prospective studies in more homogenous patients are needed to evaluate the clinical relevance of TPMT polymorphism and to determine accurate azathioprine dosing guidelines based on TPMT activity.
G Sadeghian; MA Nilforoush Zadeh; M Motevali Emami
Volume 8, Issue 4 , 2005, , Pages 251-255
Abstract
Background and objective: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis, but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance and adverse effects, efforts to find ...
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Background and objective: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis, but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance and adverse effects, efforts to find a more effective and safer drug is continuing. The objective of this study was to compare the effect of intra-lesional hypertonic sodium chloride solution and intra-lesional meglumine antimoniate injections in the treatment of cutaneous leishmaniasis.Materials and Methods: This randomized controlled clinical trial with simple sampling method was performed on 72 patients with cutaneous leishmaniasis. The patients were randomly divided in two groups. One group was treated with intra-lesional hypertonic sodium chloride solution and the other one was treated with intra-lesional meglumine antimoniate injections at weekly intervals for 6 to 10 weeks. All patients were followed for 6 months after treatment.Results: After six weeks of treatment, complete improvement, partial improvement, and no response to treatment were 33.3%, 45% and 22% in meglumine antimoniate group and 26%, 23% and 51% in trial group, respectively. In both groups complete improvement was observed in lesions smaller than 2 cm². In lesions with partial improvement the treatment was continued up to 10 weeks and all patients were followed for six months. After six months ultimate cure rate was 52% in meglumine antimoniate group and 25% in hypertonic sodium chloride solution group.Conclusion: Injections of hypertonic sodium chloride solution has less efficacy in comparison with intra-lesional meglumine antimoniate in treatment of cutaneous leishmaniasis, but considering the good response in primary small lesions, it can be used as an alternative therapy in some special cases including small lesions and allergic reactions to meglumine antimoniate.
Khooei Alireza; Farhadi Farzaneh
Volume 10, Issue 4 , 2007, , Pages 262-270
Abstract
Background and aim: The skin has some appendages that give origin to various tumors. These tumors are generally divided to pilosebaceous and sweat glands tumors according to embryologic and histological features. Clinical and histological characteristics of these tumors are also divergent. In addition, ...
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Background and aim: The skin has some appendages that give origin to various tumors. These tumors are generally divided to pilosebaceous and sweat glands tumors according to embryologic and histological features. Clinical and histological characteristics of these tumors are also divergent. In addition, classification of them according to histological background has been changed considerably in recent years. The aim of this study is to asses the frequency and clinicoepidemiologic characteristics of these tumors based on re-evaluation of the tissue specimens by applying new histological criteria for a better understanding, experience and reclassification. Materials and methods: All tissue samples with a definite, differential, probable or uncertain diagnosis of any kind of skin appendage tumors, archived in Pathology Department of Imam Reza University Hospital of Mashhad, during the past 30 years (1976-2005) were elicited. All the specimens were reobserved histopathologically by applying new diagnostic criteria and if necessary, were recut and stained with H&E and special histochemical stains. Clinical data were gathered and presented in tables and charts and analyzed statistically by SPSS software. Results: From 134748 archived specimens, 444 appendageal tumors were found of which 161 were of follicular origin composed of 119 pilomatrixoma (73.9%), 19 trichoepithelioma (11.8%), 15 inverted follicular keratoses (9.3%), 4 proliferating pilar tumor (2.5%), 2 trichoblastoma (1.2%), 1 trichofolliculoma (0.6%) and 1 trichoadenoma (0.6%), with a mean age of 28 years in 71 men and 90 women. The most prevalent location was head and neck area (57.5%) and the most common presentation was a nodule (81%), mostly single (94%). In most cases previous pathologic diagnosis was confirmed (95.2%) and clinico-epidemiologic features were in accordance with other world wide reports, although some changes in tissue diagnosis and differences in clinico-epidemiologic features were noted. Conclusion: Hair follicular tumors are relatively uncommon tumors, mostly benign and occurring in youngs specially in head and neck. Some differences in clinico-epidemiologic features could be related to race, genetic background, environment and etc. Some mistakes in previous tissue diagnosis alarm the pathologist to pay special attention to the wide range of differential diagnosis and to employ definite histopathologic criteria regarding differences in patterns of involvement.
Layegh Pouran; Panah Mohammad Javad Yazdan; Dadkhah Seyed Masoud; Shakeri Mohammad Taqi; Vosough Elham Mohammadi
Volume 9, Issue 4 , 2006, , Pages 303-307
Abstract
Background and aim: Complications and resistance to pentavalent antimonial agents in cutaneous leishmaniasis, exhibit the need for effective alternative drugs. The aim of this study was to compare the efficacy of oral azithromycin with systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous ...
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Background and aim: Complications and resistance to pentavalent antimonial agents in cutaneous leishmaniasis, exhibit the need for effective alternative drugs. The aim of this study was to compare the efficacy of oral azithromycin with systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. Materials and Methods: Forty-seven patients with cutaneous leishmaniasis visited at the dermatology department of Qaem hospital were randomly divided to two groups. Twenty patients (with 29 lesions) were treated with oral azithromycin 500 mg/day for 5 successive days each month for 4 months and 27 patients (with 58 lesions) were treated with systemic Glucantime 60 mg/kg/day for 20 days. Azithromycin group patients were visited monthly and control group patients were visited in last day of treatment and 45 days later. Results:At the end of our study 10.3% of lesions in azithromycin group showed complete response, 27.6% lesions partial response and 62.1% no response. In Glucantime group 34.5% of lesions showed complete response, 13.8% partial response and 51.7% no response (P=0.036).Conclusion: In treatment of cutaneous leishmaniasis systemic Glucantime is superior to oral azithromycin. Differences between our result and previous studies may be due to difference between strains of Leishmanias and in vitro studies may be necessary to resolve this paradox. On the other hand, change in dosage and course of treatment with azithromycin may affect the efficacy of this agent.
MA Nilforoush Zadeh; F Jafari; N Ansari; Z Nilforoushan; AR Firooz
Volume 8, Issue 5 , 2005, , Pages 340-346
F Ghalamkar Pour; H Morravej Farshi; S Zolghadr
Volume 8, Issue 6 , 2006, , Pages 448-456
Abstract
Background and aim: Side effects of long-term systemic isotretinion use with high accumulative doses on skeletal system have been known, but there are few studies about the effects of short term isotretinoin therapy for acne patients. This study was aimed to recognize the effects of systemic isotretinion ...
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Background and aim: Side effects of long-term systemic isotretinion use with high accumulative doses on skeletal system have been known, but there are few studies about the effects of short term isotretinoin therapy for acne patients. This study was aimed to recognize the effects of systemic isotretinion on calcium homeostasis and bone density in acne patients referring to clinics affiliated to the Skin Research Center of Shahid Beheshti University of Medical Sciences.Materials and Methods: In this before and after clinical trial, 20 patients with severe acne vulgaris in whom systemic treatment with isotretinoin was indicated were assessed. They included 13 female and 7 male patients with a mean age of 24.3±4.7 years. Serum levels of calcium, phosphorus and alkaline phosphatase as well as lumbar and hip bone mineral density (BMD) of the patients were evaluted before and after treatment with 120 mg/kg total dose of isotretinion. Results were analysed using Wilcoxon signed ranked test before and after treatment and P values less than 0.05 were considered statistically significant.Results: The mean levels of serum calcium and alkaline phosphatase were decreased after treatment course while the mean level of serum phosphorus was increased in comparison to their mean levels before the treatment but the changes were statistically non-significant. BMD of neck and total femur showed no significant difference, but trivial increase (0.0151 gr/cm2) was detected in lumbar BMD after treatment (P<0.05).Conclusion: Considering no significant change in neck and total femur BMD and trivial and clinically unimportant increase in lumbar BMD (L<sub>2</sub>-L<sub>4</sub>), it seems that 120 mg/kg total dose of isotretinion that is used for acne has no significant effect on skeletal system.