Iranian Society of DermatologyIranian Journal of Dermatology2717-072120120170101Comparative clinical assessment of two nasolabial hyaluronic acid fillers: A double-blind, randomized controlled trial1599398ENSaman Ahmad NasrollahiTaraneh YazdanparastSetareh AmeriShadi Marami ZonouzMansour I Nassiri-KashanAlireza FiroozJournal Article20191222Background: Various fillers have been used for the correction of nasolabial folds. This study investigated the efficacy and safety assessment of two hyaluronic acid (HA) fillers on moderate nasolabial folds. Methods: This study randomized 10 volunteers, aged 35 to 49 years, with moderate nasolabial folds. Volunteers received injections of HA A and HA B gels into the right or left skin folds. The volume and surface of nasolabial folds were analyzed using CSI computer software and high frequency ultrasonography of these folds before, and 2, 12, and 24 weeks after the injection. The obtained data were analyzed using SPSS software version 20. P≤0.05 was considered significant. Results: Evaluation of the nasolabial folds before and after treatment showed significant reduction in volume of wrinkles 24 weeks after injection in both the HA gel A (-29.93±32%, P=0.022) and gel B (-23.60±26%, P=0.019). The surfaces of the wrinkles significantly decreased 24 weeks after injection of HA gel A (-29.90±31%, P=0.012) and gel B (-21.96±26%, P=0.026). Conclusion: These HA fillers provided a significant, long-lasting correction of moderate nasolabial folds. Overall, we observed no statistically significant differences in any of the measurements between the 2 gels. However, there were more observed changes made by gel A compared to gel B.Iranian Society of DermatologyIranian Journal of Dermatology2717-072120120170101Adverse reactions associated with intravenous immunoglobulin therapy in patients with dermatologic diseases: An 11-year retrospective study61098324ENGhiasi MaryamDaneshpazhooh MaryamBalighi KamranGhiasi FatemehJournal Article19700101Background: Intravenous immunoglobulin (IVIG) is used to treat many autoimmune and immunodeficiency disorders. The main indications of IVIG in dermatology include treatment for resistant autoimmune bullous diseases, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Although generally welltolerated, various adverse effects can occur.Methods: We designed a retrospective study to investigate the adverse effects of IVIG in all patients who received this drug in Razi Hospital from 2005-2016. Information was gathered from patients’ medical records.Results: During the study period, 67 patients received 94 IVIG infusions. The most common underlying dermatologic disease was pemphigus vulgaris (54 patients). The most frequent adverse effect of IVIG therapy was an increase in blood pressure for 17 patients and in 21 infusions of IVIG. Other adverse reactions included fatigue and generalized weakness, fever, chills, tachycardia, dizziness, a decrease in blood pressure, headache, flushing, chest discomfort, hemolysis, leukopenia, and deep vein thrombosis.Conclusions: Adverse events associated with IVIG therapy are usually mild and self-limiting. The incidence of serious adverse events is low. Identification of risk factors and close monitoring of high risk patients are essential to decrease the occurrence of serious adverse events.Iranian Society of DermatologyIranian Journal of Dermatology2717-072120120170101Relationship between lichen planus and dyslipidemia: A case-control study from Southwest Iran111498327ENYaghoobi RezaPazyar NaderKalantari HoomanJournal Article19700101Background: Lichen planus (LP) is a chronic inflammatory skin condition which leads to changes in lipid metabolism. It may cause chronic atherosclerosis and metabolic syndrome. Theobjective of this study is to compare lipid levels of patients with LP to healthy controls.<br /> Methods: This case-control study recruited 100 total participants, 50 (25 male and 25 female) patients with LP and 50 healthy controls admitted to the Dermatology Clinic of Imam Hospital, Ahvaz, Iran. Serum triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol levels were measured in samples drawn after a 12-hour fasting period.<br /> Results: Patients with LP had significantly higher triglycerides (147.7 vs. 118.4 mg/dl, P<0.05), total cholesterol (188 vs. 173 mg/ dl, P<0.05), LDL (122 vs. 106 mg/dl, P<0.05), and lower HDL (49 vs. 57 mg/dl, P<0.05) levels compared to controls.<br /> Conclusion: This study showed an association between LP and dyslipidemia. Screening of serum lipids in patients with LP might be valuable to prevent cardiovascular diseases.Iranian Society of DermatologyIranian Journal of Dermatology2717-072120120170101Dermatology publications from Iran in MEDLINE: A comparison between 2004 and 2014152098328ENAghazadeh NessaRahnama NooshinNasrollahi Saman AhmadKomeili AliFirooz AlirezaDowlati YahyaJournal Article19700101Background: Iran has achieved rapid scientific growth in the past two decades. Considerable growth in scientific publications by Iranian dermatologists matches the pace of Iran’s scientific publications in the previous decade. In this study, we aim to identify the current trends in Iranian dermatology publications and authorship over the past decade.<br /> Methods: We compared papers indexed in the MEDLINE database at two time points, 2004 and 2014, using the PubMed Search engine.<br /> Results: We found 145 dermatology papers from Iran in 2014 compared to 31 papers in 2004, with an annual growth rate of 36.8%. There was a highly significant increase in the mean number of authors per article from 3.1 to 5.02 (P<0.001), with a significant decrease in the number of single-author papers. A significant decrease existed in the number of male first authors (83.9% to 63.4%; P=0.03). The number of papers published in specialized dermatology journals significantly decreased in 2014 from 80.6% to 42.1% (P<0.001), with 41.4% of the total papers published in Iranian journals. The mean impact factor (IF) per paper dropped from 2.01 to 1.75.<br /> Conclusion: The number of international publications by the Iranian dermatologist has proliferated during the past decade. Encouragement of international collaborations, production of high-quality and novel research, improvements to the standards and visibility of national journals, and higher adherence to authorship and publication ethics are essential perquisites for a more productive future for dermatology research in Iran.Iranian Society of DermatologyIranian Journal of Dermatology2717-072120120170101Diagnostic concordance among dermatopathologists in basal cell carcinoma subtyping: Results of a study in a skin referral hospital in Tehran, Iran212599399ENReza YaghoobiNader PazyarHooman KalantarAzita NikooZahra NaraghiKambiz KamyabAlireza GanadanZohre KhodashenasAzadeh GoodarziFatemeh Mohaghegh0000-0002-8492-2410Journal Article20191222Background: Basal cell carcinomas (BCC) are the most prevalent among non-melanoma skin cancers (NMSC), which correspond to the most common skin cancers. BCC histopathological subtyping is a problem in therapeutic management. Therefore, we have decided to perform a histopathologic study for better classification of BCCs based on interobserver diagnostic judgment. Methods: We conducted this cross-sectional study on 100 randomly selected pathologically confirmed BCC cases of various subtypes at Razi Hospital, Tehran, Iran during 2013 and 2014. A total of four dermatopathologists independently reviewed each pathology slide to evaluate the interobserver concordance rate. Results: The overall Fleiss’ kappa statistic (kappa) for the BCC subtypes was 0.18 (P<0.001), which indicated slight agreement. We observed moderate agreement on superficial and nodular BCC (kappa: 0.0-0.4); fair agreement on infiltrative and keratotic BCC (kappa: 0.2-0.4); and slight agreement on pigmented, micronodular, and metatypical BCC (kappa: 0.0-0.2). There was moderate agreement diagnosis for the low and high risk growth pattern categories. Conclusion: Overall, we found that the dermatopathologists had inconsistent nomenclature for the BCC subtypes, however they had better agreement for the diagnosis of superficial, nodular, and infiltrative subtypes and the high risk growth pattern.Iranian Society of DermatologyIranian Journal of Dermatology2717-072120120170101Necrobiotic xanthogranuloma after penicillin injection: A case report262898325ENEsmaeli NafisehGhanadan AlirezaMansouri ParvinGhaedi ForughJournal Article19700101Necrobiotic xanthogranuloma (NXG) is a rare, progressive, non- Langerhans cell histiocytosis characterized by multiple yellowish indurated plaques and subcutaneous nodules that frequently involve the face, trunk, and extremities. Extracutaneous manifestations and paraproteinemia are common. Here, we report the case of a 47-year-old female who referredto the Dermatology Clinic of Razi Hospital, Tehran, Iran with complaints of a yellowish swelling on her right buttock after an intramuscular injection of penicillin. A similar lesion gradually developed on her supraorbital areas after several months. Histopathological findings included granulomatous inflammation of subdermal tissue with necrobiotic foci, which confirmed the diagnosis of NXG.The patient was treated with an intralesional injection of triamcinolone and oral prednisolone. After 12 months of treatment, the plaques became considerably flatter and smaller.Iranian Society of DermatologyIranian Journal of Dermatology2717-072120120170101Relapsing Kaposi’s varicelliform eruption in a patient with Darier’s disease: A case report293198326ENKhalili MaryamMohammadi SamanAflatoonian MahinBadaksh HodaResketi Fahameh FadaeiMeymandi Simin ShamsiJournal Article19700101Darier’s disease results from abnormal keratinization of skin and is characterized by numerous keratotic papules that preferentially involve seborrheic areas. Kaposi’s varicelliform eruption (KVE) occurs by viral infections such as herpes simplex virus (HSV) in some inflammatory skin disorders like Darier’s disease. Herein, we describe a 68-year-old man, a known case of Darier’s disease, who presented with a sudden appearance of umbilicated vesiculopustular lesions on the face, trunk, and extremities.Diagnosis of KVE was confirmed by Tzanck smear and skin biopsy. Although the lesions resolved after oral acyclovir administration, the patient had recurrent episodes of KVE lessthan one month later.Iranian Society of DermatologyIranian Journal of Dermatology2717-072120120170101Brown widow spider bite (Loxosceles sp., Araneae, Sicariidae): A case report from Kashan, Iran323598329ENDehghani RouhullahTalaee RezvanRafeenejad JavadRezvani Roya SeydiKarimi FatemehJournal Article19700101A 48-year-old woman who worked as a cleaner in a Kashan University of Medical Sciences dormitory received a spider bite while collecting garbage on a summer afternoon. She feltimmediate irritation on her arm. She noticed a spider, which she removed and killed. The irritation, itching, and redness on her arm continued. Her hand became edematous and painful after four days and she suffered from insomnia. Her situation became worse to the extent that she was not able to move her fingers.The patient was hospitalized at Shahid Beheshti Hospital for four days due to the seriousness of her condition. During hospitalization, she received treatments that consisted of normalsaline, corticosteroids, antibiotics, antihistamines, and analgesics after performance of any relevant tests. A tetanus vaccine and tetabulin were also prescribed. She had complaints of ongoing pain, swelling, itching, and redness for four days after which the patient was discharged with a prescription. The spider parts were sent to the laboratory for species analysis. The laboratory results diagnosed this spider as a member of the Loxosceles species. In most cases the cause of the bite disappears and is rarely detected. Here, although damaged, the laboratory could identify the spider.