Iranian Journal of Dermatology

Vol. 15, No. 62, Winter 2012
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Efficacy of dinitrochlorobenzene in the treatment of alopecia areata
Zahra Fazel, Mahnaz Banihashemi, Mohammad-Javad Yazdanpanah, Hadis Yousefzadeh

Contact Info: Mahnaz Banihashemi, MD Research Center for Skin Diseases and Cutaneous Leishmaniasis, Department of Dermatology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran E- mail:

Date Received: 2012 / Jul / 10 Date Revised: 2012 / Jul / 10 Date Accepted: 2012 / Sep / 19

Background: Various kinds of sensitizers are administrated for
alopecia areata treatment. The aim of this study was to evaluate
treatment response to Dinitrochlorobenzene (DNCB) in alopecia
areata patients.
Method: In this study, 117 patients were treated with DNCB
under a specific checklist. All patients were sensitized with a 2%
DNCB and then treated with ascending DNCB concentrations
(0.001%-2%). Response to treatment was categorized as none,
mild, moderate and marked improvement.
Result: Thirty three (27.5%) patients showed no response, 49
(40.8%) had relapse 6 months after improvement, 29 (24.2%)
had no relapse 6 months after the treatment and 6 patients
were excluded because they did not return for follow-up visits.
Response to treatment in patients without eyelash and eyebrow
involvement increased significantly (P=0.01). We did not observe
any side effects except for localized dermatitis seen in 5% of the
Conclusion: With respect to the suitable response to DNCB
application and its availability, the authors suggest that DNCB
be reconsidered in alopecia areata. However, attention must be
paid to its mutagenicity..

Keywords: alopecia areata, contact sensitizer, dinitrochlorobenzene

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