Iranian Journal of Dermatology

Vol. 15, No. 62, Winter 2012
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Confluent and reticulate papillomatosis: response to topical terbinafine and oral fluconazole; a case report
Pedram Noormohammadpour, Somayeh Khezri, Zahra Safaee Naraghi, Alireza Ghanadan, Farzaneh Khezri

Contact Info: Somayeh Khezri, MD Department of Dermatology, Razi skin hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Email:

Date Received: 2011 / Oct / 21 Date Revised: 2011 / Oct / 21 Date Accepted: 2011 / Nov / 16

Confluent and Reticulate Papillomatosis (CRP) is a rare disease with
poorly recognized etiology. Various agents such as antibacterial,
topical/systemic antifungal and topical/oral retinoids have been
used as treatment. Here, we report a 15-year-old female with
CRP in whom yeasts of Malassezia were found in the PAS stain
of the skin lesions. Topical terbinafine hydrochloride 1% spray
and oral fluconazole disappeared the lesions, supporting the
hypothesis that CRP maybe a reactive dermatosis to Malassezia..

Keywords: confluent and reticulate papillomatosis, fluconazole, terbinafine, treatment

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