Iranian Journal of Dermatology

Vol. 16, No. 63, Spring 2013
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Association of vitamin D level with alopecia areata
Soheila Nassiri, Zahra Saffarian, Shima Younespour

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Date Received: 2013 / Jul / 22 Date Revised: 2013 / Jul / 22 Date Accepted: 2013 / Jul / 22

Background: Alopecia areata (AA) is an autoimmune disorder of
hair follicles. We aimed to find the association between Vitamin
D level and AA.
Method: Eligible AA patients and controls were enrolled in
this case-control study and serum samples were assessed for
25-hydroxy vitamin D (25-(OH)-D3). The levels of 25-(OH)-D3
were categorized as deficient (<10ng/ml), insufficient (10 to
<30 mg/ml) and sufficient (>30ng/dl) and the SALT (Severity
of Alopecia Tool) score was used to assess the severity of the
disease. The data was analysed and the association between
vitamin D levels and AA, disease distribution, and the pattern
of hair loss was investigated.
Result: Twenty eight patients (19 males, 9 females) and 44
healthy controls (16 males, 28 females) were assessed. There
was no statistically significant difference between patients and
controls with regard to the level of 25(OH)D3 when the data was
adjusted for gender (Ordinal odds ratio: 0.49 (0.18-1.34 and 95%
CI, p-value=0.16). The level of 25(OH)D3 was lower in patients
with nail involvement in contrast to those without it (P=0.02);
moreover, no significant difference was found between patients
with different patterns of hair loss.
Conclusion: After adjustment for gender, there was no association
between AA and the level of vitamin D.


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