Iranian Journal of Dermatology

   
 
Vol. 16, No. 63, Spring 2013
«« Previous 3 of 10 Next »»

Relationship between the serum TGF beta 1 level and anti organ-specific antibodies in vitiligo patients
Mohammad Shahidi-Dadras, Parviz Toossi, Reza Jafari Fesharaki, Azin Ayatollahi, Mehdi Qeisari, Shima Younespour

Contact Info:


Date Received: 2013 / Jul / 22 Date Revised: 2013 / Jul / 22 Date Accepted: 2013 / Jul / 22

Abstract:
Background: To our knowledge, there is a hypothesis regarding
the association of vitiligo with other autoimmune disorders.
Organ-specific autoantibodies are found more frequently in the
serum of vitiligo patients. Recent studies have demonstrated
the role of alterations in serum transforming growth factor-beta
(TGF-beta) released from regulatory T cells in the pathogenesis
of depigmentation observed in vitiligo. It has been shown that in
comparison with patients without autoimmune diseases, serum
TGF-beta levels increase in patients whose vitiligo is associated
with autoimmune diseases. We hypothesized a relationship
between serum TGF-beta levels and organ-specific autoantibodies
that could predict other autoimmune diseases in vitiligo patients.
Method: Forty-five patients with a mean age of 35.96±13.34
years who had stable vitiligo since 1 year ago and involvement
of up to 30% body surface area were enrolled. Organ-specific
autoantibodies (ANA, anti mitochondrial Ab, anti TPO (anti
thyroid microsomal Ab), anti parietal cell Ab, anti thyroglobulin
Ab) and serum TGF-beta level were evaluated.
Result: Twenty-three patients (51.11%) had at least one positive
organ-specific autoantibody. Anti TPO in 16 patients, anti
thyroglobulin Ab in 9 patients, anti parietal cell Ab and ANA
each in 5 patients, and anti mitochondrial Ab in 4 patients were
positive. Mean serum TGF-beta level was 105.82±30.33; there was
no significant difference in serum TGF-b level between patients
with and without positive organ-specific autoantibody (P=0.26).
Conclusion: Although another study showed the relationship
between serum TGF-beta levels and autoimmune disorders
in vitiligo patients, we did not find a significant difference in
serum TGF-beta levels in these patients regarding the positivity
of organ-specific antibodies. It may be due to the fact that our
patients had autoantibodies without clinical autoimmune disease
except vitiligo.

Keywords:


Full Text | XML
All Rights Reserved to Iranian Journal of Dermatology
Powered by Health Researchers R&D Institute