Iranian Journal of Dermatology

   
 
Vol. 16, No. 63, Spring 2013
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Cryotherapy is more effective and faster than Q-switched Nd-YAG laser fordepigmentation in universal vitiligo patients
Mohammad Radmanesh, Ramin Radmanesh

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Date Received: 2013 / Jul / 22 Date Revised: 2013 / Jul / 22 Date Accepted: 2013 / Jul / 22

Abstract:
Background: Although cryotherapy has been reported as a
technique for depigmenting residual pigmented patches in
patients with universal vitiligo, Q-switched Nd-YAG lasers
have not yet been used for this purpose. The aim of this study
was to compare the efficacy of cryotherapy with that of 532nm
Q-switched Nd-YAG laser therapy for depigmentation in patients
with universal vitiligo.
Method: Six adult patients (4 male and 2 female) with universal
vitiligo and facial residual pigmented patches were treated
simultaneously with cryotherapy on the right and the frequencydoubled
532nm Q-switched Nd-YAG laser therapy on the left
side. The laser parameters used were spot size 3-5mm, frequency
rate 10 hertz, and the fluence was 5J/cm2. The cryo system was
a closed contact CO2 Cryo gun. The patients were scheduled to
be treated monthly.
Result: The depigmentation was complete after three successive
sessions of cryotherapy and 30-45 days after the last session, in
comparison with simultaneous 30-70% depigmentation of the laser
side. No scar or permanent sequellae developed on either side.
Conclusion: Cryotherapy is more effective and fast-acting
than Q-switched Nd-YAG laser for depigmentation of residual
pigmented patches in patients with universal vitiligo.

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