Iranian Journal of Dermatology

Vol. 16, No. 66, Winter 2013
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Eficacy of calcipotriol in the treatment of seborrheic keratosis: a pilot study
Maryam Yousefi, Leyla Nabaei, Hassan Ghasemnia, Ehsan Abolhasani, Rayhaneh Rahgoshai, Behrooz Barikbin

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Date Received: 2014 / Apr / 12 Date Revised: 2014 / Apr / 12 Date Accepted: 2014 / Apr / 12

Background: Seborrheic keratosis is a common benign tumor and
many modalities are used to treat it. No convincing data favors
the therapeutic effect of calcipotriol on seborrheic keratosis. We
aimed to assess the efficacy of calcipotriol in the treatment of
this tumor.
Method: Eligible patients aged over 40 years with seborrheic
keratosis (size: 5-15mm) were instructed to apply 50?g/g
calcipotriol ointment twice a day for 12 weeks. The size of the
tumor was measured at baseline and after the 12-week period.
The size change and improvement were assessed.
Result: Thirty out of fifty screened patients were eligible for the
study and completed the 12-week course of the study. The mean
baseline size of the tumors was 9.30±2.95 mm that decreased to
the mean size of 2.02±1.94 mm (P<0.05). The mean percent of
improvement was 80.46±17.66% and 6 patients demonstrated 100%
improvement. The mean percent of improvement revealed no
difference between male and female participants. An intermediate
negative correlation existed between the tumor size and the
improvement. No serious side effects were reported by patients.
Conclusion: Our study concluded that calcipotriol might be
effective and safe in the treatment of seborrheic keratosis tumors
with slightly better outcomes in smaller tumors. Controlled studies
with larger sample sizes should be performed in order to find
the effect of calcipotriol on this dermatologic entity.

Keywords: calcipotriol, seborrheic keratosis, topical administration, vitamin D analogues

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