Pyogenic granuloma (PG) is a common, acquired tumor-like growth occurring on skin/mucous membranes. It is prevalent in the pediatric age group. It is benign in nature and is caused by chronic low grade trauma. It presents as pink to red elevated pedunculated or sessile mass. There are various treatment modalities including surgery, cryotherapy, laser, electrocautery, etc. However, the therapeutic effects are limited with high recurrence rates. The use of sclerotherapy for the treatment of pyogenic granuloma in children is not commonly reported. We present a case of PG on the scalp successfully treated with intralesional injection of sodium tetradecyl sulfate.