Background: Treatment of vitiligo remains an attractive topic and several therapies with varying degrees of success have been used. The aim of this study was to find out whether the combination of topical calcipotriol and excimer laser increases the efficacy of therapy compared to excimer laser alone. Methods: Twenty eight patients in two groups were treated with 308nm excimer laser alone (14 patients) and the combination of excimer laser–calcipotriol (14 patients). After 16 sessions, response rate, side-effects and compliance were assessed. Results: Repigmentation rate more than 50% was significantly higher in the laser- calcipotriol group. No differences were seen in complication rate between the two groups. Conclusion: Combination of calcipotriol and 308nm excimer laser might enhance the response rate without increasing treatment complications.