Firooz Alireza; Handjani Farhad; Lajevardi Vahideh; Mansouri Parvin; Nassiri-Kashani Mansour; Norouzi Yasaman
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria. Iranian Society of Dermatology developed ...
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Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria. Iranian Society of Dermatology developed a clinical practice guideline concerning diagnosis and treatment of urticaria that was published in 2015. The current guideline is an update to the previous one and includes findings related to this subject which has been published in the medical literature from 2015 to August 2018.
Aghazadeh Nessa; Rahnama Nooshin; Nasrollahi Saman Ahmad; Komeili Ali; Firooz Alireza; Dowlati Yahya
Volume 20, Issue 1 , 2017, , Pages 15-20
Abstract
Background: Iran has achieved rapid scientific growth in the past two decades. Considerable growth in scientific publications by Iranian dermatologists matches the pace of Iran’s scientific publications in the previous decade. In this study, we aim to identify the current trends in Iranian dermatology ...
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Background: Iran has achieved rapid scientific growth in the past two decades. Considerable growth in scientific publications by Iranian dermatologists matches the pace of Iran’s scientific publications in the previous decade. In this study, we aim to identify the current trends in Iranian dermatology publications and authorship over the past decade. Methods: We compared papers indexed in the MEDLINE database at two time points, 2004 and 2014, using the PubMed Search engine. Results: We found 145 dermatology papers from Iran in 2014 compared to 31 papers in 2004, with an annual growth rate of 36.8%. There was a highly significant increase in the mean number of authors per article from 3.1 to 5.02 (P<0.001), with a significant decrease in the number of single-author papers. A significant decrease existed in the number of male first authors (83.9% to 63.4%; P=0.03). The number of papers published in specialized dermatology journals significantly decreased in 2014 from 80.6% to 42.1% (P<0.001), with 41.4% of the total papers published in Iranian journals. The mean impact factor (IF) per paper dropped from 2.01 to 1.75. Conclusion: The number of international publications by the Iranian dermatologist has proliferated during the past decade. Encouragement of international collaborations, production of high-quality and novel research, improvements to the standards and visibility of national journals, and higher adherence to authorship and publication ethics are essential perquisites for a more productive future for dermatology research in Iran.
Kamyab Kambiz; Firooz Alireza; Kohsari Laleh Montaser; Noorian Negin; Khorshid Hamidreza Khorram; Khatami Alireza; Estarabadi Ali Rajabi
Volume 19, Issue 3 , 2016, , Pages 86-88
Abstract
Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment ...
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Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment of sarcoidosis. We aimed to evaluate the role of this gene in patients with skin sarcoidosis in comparison with skin sarcoidal reaction patients and those with normal skin. Methods: The nucleotide sequence of rs2076530 allele in exon 5 of BTNL2 gene was compared among the paraffin-embedded blocks of 34 patients with a histologic diagnosis of sarcoidosis, 14 patients with skin sarcoidal reaction (tattoo, foreign body), and 27 patients with normal skin (excised during cosmetic surgery) using polymerase chain reaction. Results: There was no statistically significant difference in the frequency of 3 genotypes of AA, AG, and GG in rs2076530 allele among skin sarcoidosis, skin sarcoidal reaction, and normal skin. Conclusion: The expression of rs2076530 allele of BTNL2 gene in skin sarcoidosis or sarcoidal reaction does not differ with its expression in the normal skin.
Nasrollahi Saman Ahmad; Hasanzadeh Hournaz; Ajami Marjan; Ameri Setareh; Variji Zeinab; Komeili Ali; Firooz Alireza
Volume 18, Issue 4 , 2015, , Pages 145-150
Abstract
Background: Cellulite is a common disease whose exact mechanism is unknown. This study was aimed to assess the safety and efficacy of an anti-cellulite preparation compared with placebo in a randomized double-blind, right-left comparison clinical trial.Methods: Twelve healthy women aged 22 to 58 years ...
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Background: Cellulite is a common disease whose exact mechanism is unknown. This study was aimed to assess the safety and efficacy of an anti-cellulite preparation compared with placebo in a randomized double-blind, right-left comparison clinical trial.Methods: Twelve healthy women aged 22 to 58 years with mild to moderate cellulite on their thighs and buttocks participated in this trial. The anti-cellulite preparation (Three O cream, Pouya Varzan Tejarat Sepahan Co., Iran) and an identical placebo were randomly applied on the right or left thigh and buttock twice a day for 2 months. The mentioned areas were photographed and the circumference, subcutaneous fat thickness, and dermis density and thickness were measured before and after treatment. A satisfaction questionnaire was completed by all volunteers to assess their satisfaction with the efficacy of treatment on each side.Results: There was no significant difference between active and placebo treatment sides in any of measurements. About 90% of participants had an overall satisfaction of 5 and more than 5 based on a 0 to 10 visual analogue scale on the side of anti-cellulite cream. This score was similar on the sides treated with placebo and the active product.Conclusion: Although Three O cream provided more satisfaction in volunteers than placebo, the objective measurements did not show any difference between them.
Firooz Alireza; Hallaji Zahra; Khatami Alireza; Lajevardi Vahideh; Mansouri Parvin; Pedram Mehryan; Zohreh Mozafari; Mansour Nassiri-Kashani; Reza Robati; Hassan Seirafi
Volume 18, Issue 3 , 2015, , Pages 81-96
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.One of the missions of the Iranian ...
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Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.One of the missions of the Iranian Society of Dermatology is to develop strategies in order to provide the best possible management for patients suffering from dermatological conditions. To accomplish this mission, the Society assigned a committee to search and critically appraise the recent research evidence and available guidelines to develop a clinical practice guideline concerning diagnosis and treatment of urticaria.
Kashani Mansour Nassiri; Estarabadi Ali Rajabi; Zartab Hamed; Khoshpouri Parisa; Khoshpouri Pegah; Hosseini Hamed; Tavakoli Amir Hossein; Firooz Alireza
Volume 18, Issue 3 , 2015, , Pages 97-103
Abstract
Background: With aging, the facial folds, grooves, and sagging tissue become more prominent. It is haracterized by loss of the collagen mass in the dermis and an increased array of elastin whirls in the deeper dermis. The aim of this study was to determine whether correction of nasolabial folds could ...
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Background: With aging, the facial folds, grooves, and sagging tissue become more prominent. It is haracterized by loss of the collagen mass in the dermis and an increased array of elastin whirls in the deeper dermis. The aim of this study was to determine whether correction of nasolabial folds could be achieved using an allogeneic collagen product. Methods: Nine healthy volunteers participated in this beforeafter, pilot clinical trial. Human allogeneic collagen (Collagel, Kimia Teb Rahavard Co., Tehran, Iran) was injected in both nasolabial folds of the volunteers. Skin hydration was measured using the Corneometer® 580 device (CK GmbH, Cologne, Germany). Ultrasonic dermal changes were measured using an ultrasonography device (22 MHz, TPM, Germany) before and 24 weeks after the injection. One independent investigator assessed the efficacy using standardized photographs before and 24 weeks after injections. The patients’ satisfaction rate was also evaluated.Results: All patients showed improvement in wrinkles and the mean satisfaction rate on a 0-10 VAS was 7.4±0.5. The hydration of the stratum corneum increased from 32.32±13.54 to 52.61±12.55 and the echo-density of the dermis increased from 8.05±3.18 to 9.55±3.36 μm 24 weeks after the injection (P≤0.05). No treatmentrelated adverse events were reported.Conclusion: Collagel is an effective filler that can provide a safe and effective correction of the nasolabial folds. This correction lasts for at least 24 weeks on ultrasound evaluations. Further larger blind-randomized controlled clinical trials are required to pave the way for suggesting it as a possible therapeutic option.
Nassiri-Kashani Mansour; Nassiri-Kashani Mohammad Hassan; Khatami Alireza; Ghafari Mostafa; Firooz Alireza; Dowlati Yahya
Volume 17, Issue 2 , 2014, , Pages 49-53
Abstract
Background: Job-related allergic contact dermatitis (ACD) mayprolong the disease duration, increase disabilities, and decreasethe patient’s quality of life. The aim of this study was to determinecommon allergens causing ACD, investigating certain featuresof the disease and evaluating its relation ...
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Background: Job-related allergic contact dermatitis (ACD) mayprolong the disease duration, increase disabilities, and decreasethe patient’s quality of life. The aim of this study was to determinecommon allergens causing ACD, investigating certain featuresof the disease and evaluating its relation to the patients’ jobs.Method: In this cross-sectional study, relevant data was obtainedfrom patch test clinics at the Center for Research and Trainingin Skin Diseases and Leprosy, Tehran University of MedicalSciences, and two private dermatology clinics in Tehran, Iran.Nine hundred and forty six patients from different regions of Iranwith a probable diagnosis of ACD were recruited into the study.Patch testing was used as the gold standard test to differentiateACD from other differential diagnoses.Result: Of 946 studied patients with a probable diagnosis ofACD, 649 (68.6%) cases were females. The mean age ± standarddeviation (SD) of the patients was 31.9 ± 12.3 years. Five hundredand twenty eight (55.7%) cases had positive patch test results toat least one tested allergen. Comparing job-related and non jobrelatedACD patients revealed that while there was a significantdifference in the mean age of the two group (30.6 ± 11.3 vs.32.7 ± 12.9 years in job-related and non-job-related groups,respectively) (P=0.016), there were no significant differences inthe gender distribution, number of positive patch tests, frequencyof allergens, reaction time, and severity of reactions between thetwo groups. Nickel sulphate and cobalt chloride were the twomost common allergens in both groups.Conclusion: Job-related patients were younger and most of themwere female compared to non job-related patients. However,other characteristics were not different between the two groups.
Davoudi Seyyed Masoud; Keshavarz Saeed; Sadr Bardia; Shohrati Majid; Naghizadeh Mohammad Mehdi; Farsinejad Khalil; Rashighi-Firouzabadi Mehdi; Zartab Hamed; Firooz Alireza
Volume 11, Issue 4 , 2008, , Pages 151-155
Abstract
Background: Sulfur mustard gas is a chemical agent that has been used in many wars, especially in Iran-Iraq war. This chemical agent affects many organs including lungs, eyes and skin, causing numerous acute and chronic lesions including erythema and hyperpigmentation, respectively. This study was conducted ...
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Background: Sulfur mustard gas is a chemical agent that has been used in many wars, especially in Iran-Iraq war. This chemical agent affects many organs including lungs, eyes and skin, causing numerous acute and chronic lesions including erythema and hyperpigmentation, respectively. This study was conducted to evaluate erythema and melanin in subjects with a history of exposure to sulfur mustard.Methods: This case-control study was done on 309 subjects. They were divided into four groups: sulfur mustard-exposed patients with skin lesions (n=87), sulfur mustard-exposed cases without current skin lesions (n=71), non sulfur mustard-exposed patients with dermatitis (n=78) and normal controls (n=74). Erythema and melanin were measured in 4 areas (forehead, suprasternal, palm and back of hands) by Mexameter MX18 (Courage-Khazaka, Germany).Results: Erythema was significantly lower in suprasternal and palmar aspect of hands in sulfur mustard-exposed patients with dermatitis (P<0.05) while there was no significant difference in other areas. In terms of melanin, there was a significant difference in the dorsal aspect of hands in all four groups (P<0.05), where patients with dermatitis (both sulfur mustard exposed and normal population) had higher levels of melanin, probably due to pruritus in such areas. Forehead melanin of the normal population was also significantly lower than other three groups (P<0.05) while there was no significant difference between the melanin level of sulfur mustard exposed subjects (with or without dermatitis) and patients with dermatitis.Conclusion: Sulfur mustard contact can affect erythema and melanin content of the skin.
Davari Parastoo; Gorouhi Farzam; Jafarian Sirous; Firooz Alireza
Volume 11, Issue 2 , 2008, , Pages 49-54
Abstract
Background: Microdermabrasion has recently become a popular procedure among physicians and patients, whereas few studies have assessed the efficacy of different microdermabrasion protocols nowadays applied.The objective of this study was to assess the effects of microdermabrasion, as well as to compare ...
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Background: Microdermabrasion has recently become a popular procedure among physicians and patients, whereas few studies have assessed the efficacy of different microdermabrasion protocols nowadays applied.The objective of this study was to assess the effects of microdermabrasion, as well as to compare the effects of weekly and biweekly intervals of microdermabrasion sessions on skin biophysical parameters. Methods: Ten patients entered this randomized, investigator-blind, split face study and underwent a series of six microdermabrasion treatments. One side of the face was treated every week and the other side was treated every 2 weeks, randomly. Stratum corneum hydration, sebum secretion and skin pH measurements were taken before and after the procedure on all sessions and also 1 and 4 weeks after the last treatment. Results: After 6 sessions of microdermabrasion and following comparison to baseline, a significant decrease in sebum content and a significant increase in skin pH were observed only on the side treated with the intervals of 2 weeks. Changes in skin hydration were not significant on either side. Conclusion: Microdermabrasion may have noticeable effects on skin barrier functions. It is recommended to have 2 week interval between sessions.
Shizarpour Mohammad; Firooz Alireza; Pazooki Hamidreza; Khiabanloo Samad Rezai
Volume 11, Issue 2 , 2008, , Pages 67-72
Abstract
Background: Acne vulgaris is the most common cause for dermatology visits and is one of the most common diseases that people experience during their lives. Although this disease is not life-threatening, it may affect the life quality of the patients because of developing irreparable complications on ...
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Background: Acne vulgaris is the most common cause for dermatology visits and is one of the most common diseases that people experience during their lives. Although this disease is not life-threatening, it may affect the life quality of the patients because of developing irreparable complications on the skin. Dermatologists are in agreement about topical treatment in the mild to moderate acne vulgaris, but extensive using of tropical antibiotics and drug resistance have decreased their therapeutic benefits. In this study, we tried to compare the therapeutic effects of tropical azithromycin and clindamycin. Methods: This study was designed and performed as a double blind, randomized clinical trial. Thirty two patients with mild to moderate acne were treated with azithromycin and 30 patients, who were matched with the former group based on age, sex and severity of the disease, were treated with clindamycin for 12 weeks and results of their treatment were compared with each other. Results: results of this study showed that ratio of response to treatment and decreasing the grade of the disease and number of nodules, papules and pustules were not significantly different in the first month of the treatment in both groups while just the number of nodules in the group on azithromycin showed more decrease in the last months of treatment in comparison with clindamycin (0.88±0.75 vs. 0.25±0.75, p=0.015). Also, clindamycin had more side effects, but the rate of satisfaction with both drugs were high and showed no difference. In this study, no significant association was found between sex and response to treatment and evaluation of association between age and response to treatment showed a significant reverse association between age and decreasing the number of pustules (p=0.002 , r= - 0.492). Conclusion: sum of findings in this study show that topical azithromycin is an effective antibiotic with acceptable side effects and high degree of satisfaction in patients and it can be used for the treatment of mild forms of acne.
Akhyani Maryam; Jafari Alireza Keshtkar; Seyrafi Hassan; Ghaninedjad Hayedeh; RezaPazouki Hamid; Tousi Siavash; Robati Reza Mahmood; Davari Parastoo; Firooz Alireza
Volume 11, Issue 1 , 2008, , Pages 7-10
Abstract
Background: Latanoprost, a prostaglandin F 2a analogue, is an intraocular pressure lowering drug used in the treatment of glaucoma. Increase in eyelash number, length, pigmentation, curvature is reported after using topical Latanoprost in these patients. The aim of this study was to evaluate the effect ...
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Background: Latanoprost, a prostaglandin F 2a analogue, is an intraocular pressure lowering drug used in the treatment of glaucoma. Increase in eyelash number, length, pigmentation, curvature is reported after using topical Latanoprost in these patients. The aim of this study was to evaluate the effect of Latanoprost ophthalmic solution on eyelash regrowth in patients with alopecia areata.Methods: Fifteen patients with alopecia areata and bilateral eyelash involvement, who showed excellent response to diphencyprone therapy, entered the study to be treated with Latanoprost ophthalmic solution. In each patient, one eye was randomly treated with Latanoprost daily over 3 months. To assess the eyelash changes, patients were followed up monthly. Results: Ten patients completed the study. Two patients had significant eyelash regrowth of both eyes. One patient showed eyelash regrowth on upper eyelid of the eye treated with Latanoprost. Conclusion: In this study, Latanoprost was not effective in treatment of alopecia areata of eyelashes. It is advisable to evaluate the efficacy of higher concentration and/or more frequent application of the Latanoprost with an appropriate vehicle for the treatment of alopecia areata of eyelashes.
Firooz Alireza; Nassiri-Kashani Mansour; Gorouhi Farzam; Davari Parastoo; Yaghoubi Reza; Farshchian Mahmoud; Esfandiarpour Iraj; Golchai Mohammad Javad; Dowlati Yahya
Volume 10, Issue 3 , 2007, , Pages 187-195
Abstract
Background and aim: The frequency of sensitization to contact allergens varies in different countries because of both genetic and, more importantly, allergen exposure variations. The objective is to determine the frequency of sensitization to contact allergens in Iranian patients with dermatitis.Materials ...
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Background and aim: The frequency of sensitization to contact allergens varies in different countries because of both genetic and, more importantly, allergen exposure variations. The objective is to determine the frequency of sensitization to contact allergens in Iranian patients with dermatitis.Materials and methods: Four hundreds and one patients with a clinical diagnosis of contact dermatitis and/or atopic dermatitis were evaluated with a 24-allergen European standard series in four major cities in Iran. The patches were applied on the back of the patients, removed after 24 hours and the readings were taken on 24, 48 and 72 hours after application.Results: One hundred and seventy six patients (43.8%) showed at least 1 positive reaction with a total positive reactions of 268, and 64 patients (15.9%) had 2 or more positive reactions. The 5 most common allergens were nickel sulfate [64 (15.9%)], potassium dichromate [40 (10.0%)], thiuram mix [27 (6.7%)], cobalt chloride [23 (5.7%)], and Balsam of Peru [17 (4.2%)]. Contact allergy to nickel sulfate was significantly more common in female patients and in patients under 40 years of age (P<0.001).Conclusion: Nickel sulfate is the most common contact allergen in Iran, mostly affecting women and younger patients probably because of more exposure. Thiuram had a significant increase in its prevalence during the previous years and further studies need to distinguish its causes.
Samadi Zaynab; Gorouhi Farzam; Davari Parastoo; Firooz Alireza
Volume 9, Issue 4 , 2006, , Pages 335-342
Abstract
Background and aim: Pemphigus vulgaris (PV) is the most common blistering disease in Iran and many other Asian countries with a relatively high incidence and involvement of both skin and mucous membrances in majority of patients. The aim of this study was to assess the opinions of Asian experts on the ...
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Background and aim: Pemphigus vulgaris (PV) is the most common blistering disease in Iran and many other Asian countries with a relatively high incidence and involvement of both skin and mucous membrances in majority of patients. The aim of this study was to assess the opinions of Asian experts on the diagnosis and management of PV. Materials and Methods: A questinnaire-based mailed/emailed survey was conducted. The questionnaire was sent to 29 dermatologists from different countries of Asia (23 from Iran and 6 from India, Kuwait, Turkey and Bangladesh) who are in charge of the treatment of autoimmune blistering disorders with at least 5 years experience in this field who visit at least five new PV patients annually. Questions incluced duration of experience, number of patients treated and diagnostic and treatment approaches for PV. Descriptive data were reported using SPSS 11.5 and some data are reported as mean±SD. Results: All 29 physicians participated in the survey. Among them, 79.3% visit their patients within 6 months after the onset of symptoms. Diagnosis of PV is confirmed by histologic and direct immunofluorescence examinations by 65.5% of physicians. All of them initiate the treatment with corticosteroids (48.3% with a dose of at least 2 mg/kg/day prednisolone) and 89.7% add adjuvant immunosuppressors at the same time. Of the adjuvant agents used, azathioprine is used by 82.8% of physicians. Conclusion: Different trends in diagnostic techniques and treatment options for PV among the experienced authorities emphasize the urgent need for large-scale controlled trials to reach consensus standards in this field. In addition, regional and worldwide consensus meetings to consider all regional and genetic similarities and differences are highly recommended.